cell_type

Astrocyte

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Astrocyte: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4566Connections

21Hypotheses

30Analyses

50Outgoing

50Incoming

Summary

Astrocyte is a cell type relevant to neurodegeneration research. Key relationships include: expressed in, involved in, interacts with. Connected to 128 entities in the SciDEX knowledge graph.

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🧫 Cell Type Info

Cell Type	Astrocyte
Related Genes	CHI3L1, SAPAP3
Linked Hypotheses	159 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Clinical Management Guide for CBS/PSP

therapeutic · 15224 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

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Pathway Diagram

graph TD
    Astrocyte["Astrocyte"] -->|"involved in"| APOE_Pathogenesis["APOE Pathogenesis"]
    Astrocyte["Astrocyte"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
    THY1["THY1"] -->|"interacts"| Astrocyte["Astrocyte"]
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| Astrocyte["Astrocyte"]
    AGING["AGING"] -->|"expressed in"| Astrocyte["Astrocyte"]
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| Astrocyte["Astrocyte"]
    style Astrocyte fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (2077)

Target	Relation	Type	Str
Alzheimer'S Disease	involved_in	disease	0.95
Neuroprotective Astrocyte Reactivity	involved_in	phenotype	0.95
Neurotoxic Astrocyte Reactivity	involved_in	phenotype	0.95
Glymphatic System	involved_in	process	0.95
Microglia	interacts_with	cell_type	0.90
CHI3L1	product_of	protein	0.90
Neuroinflammation	mediates	process	0.90
Excitotoxicity	mediates	process	0.90
Synaptic Dysfunction	contributes_to	phenotype	0.90
Active Lesion Rim	involved_in	phenotype	0.90
Alzheimer's Disease Continuum	involved_in	disease	0.90
APOE Pathogenesis	involved_in	process	0.85
CLU	expressed_in	protein	0.85
Blast-Induced Injuries	involved_in	disease	0.85
Neuron	interacts_with	cell_type	0.80
Dopaminergic Neuron	interacts_with	cell_type	0.80
Immune Gene Expression	upregulates	process	0.80
Microglia	mediates	cell	0.80
Microglial Memory	erases	mechanism	0.80
Microglia	communicates_with	cell	0.80
Neuronal Degeneration	modulates	process	0.75
Neuroinflammation	activates	entity	0.70
Aβ	promotes_clearance	protein	0.70
Cytokine	produces	molecule	0.70
OLIGODENDROCYTES	activates	concept	0.50
DEMYELINATION	activates	concept	0.50
AMYLOID-β	associated_with	concept	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
NEURONS	associated_with	concept	0.50
CX43	associated_with	concept	0.50
disease	interacts_with	disease	0.50
PARKINSON'S	interacts_with	concept	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
Neuron	protects_against	cell_type	0.50
NEURONS	protects_against	concept	0.50
NEURONS	interacts_with	concept	0.50
DOPAMINERGIC	interacts_with	concept	0.50
DOPAMINERGIC NEURONS	interacts_with	concept	0.50
Spinal Cord	activates	cell_type	0.50
Sepsis	interacts_with	disease	0.50
PROINFLAMMATORY CYTOKINES	activates	concept	0.50
PPAR-Γ	activates	concept	0.50
CENTRAL NERVOUS SYSTEM	activates	concept	0.50
disease	causes	disease	0.50
Cognitive Decline	causes	disease	0.50
STEM CELLS	activates	concept	0.50
Oligodendrocyte	activates	cell_type	0.50
Macrophage	activates	cell_type	0.50
MONOCYTES	activates	concept	0.50

Incoming (2489)

Source	Relation	Type	Str
SAPAP3	expressed_in	gene	0.90
SNCA	activates	protein	0.90
TNBC	interacts_with	disease	0.85
Microglia	interacts_with	cell_type	0.80
OLIG1	regulates	gene	0.80
OLIG2	regulates	gene	0.80
BMP7	regulates	entity	0.80
Cholesterol	regulates	chemical	0.80
NEMO	expressed_in	protein	0.80
MALAT1	expressed_in	gene	0.80
APOE	modulates	protein	0.80
THY1	interacts_with	protein	0.70
P2RY1	expressed_in	gene	0.60
AGING	therapeutic_target	gene	0.60
MCT8	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
ASTROCYTE	causes	gene	0.60
COMPLEMENT	causes	gene	0.60
ASTROCYTES	causes	gene	0.60
CD19	therapeutic_target	gene	0.60
AQP4	causes	gene	0.60
STROKE	regulates	gene	0.60
PIEZO1	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
ASTROCYTES	regulates	gene	0.60
EXERCISE	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
TAUOPATHY	activates	gene	0.60
APOE3	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
TAU	activates	gene	0.60
APOE	therapeutic_target	gene	0.60
NEURON	therapeutic_target	gene	0.60
ASTROCYTES	activates	gene	0.60
MICROGLIA	activates	gene	0.60
APOE4	therapeutic_target	gene	0.60
ABCA1	therapeutic_target	gene	0.60
ALZHEIMER	activates	gene	0.60
APOE	activates	gene	0.60
APOE4	activates	gene	0.60
ASTROCYTE	associated_with	gene	0.60
APOE3	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
TAU	associated_with	gene	0.60
APOE	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
APOE4	associated_with	gene	0.60
APOE3	activates	gene	0.60

Targeting Hypotheses (21)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Beta-frequency entrainment therapy targeting PV interneuron-	0.669	Alzheimer's disease	Circuit-level neural dynamics in neurode
TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen	0.639	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene	0.612	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegener	0.607	neurodegeneration	Gene expression changes in aging mouse b
Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S	0.599	neurodegeneration	What are the mechanisms by which gut mic

C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward	0.596	neuroinflammation	What molecular mechanisms determine whet
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene	0.585	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene	0.580	neurodegeneration	Gene expression changes in aging mouse b
AMPK hypersensitivity in astrocytes creates enhanced mitocho	0.570	neurodegeneration	Mitochondrial transfer between astrocyte
Adenosine-Astrocyte Metabolic Reset	0.557	neurodegeneration	Sleep disruption as cause and consequenc
Astrocyte-Selective APOE4 Silencing via Lipid Nanoparticles	0.529	neurodegeneration	Which cell types show the most significa
Heterogeneous astrocyte activation states differentially imp	0.523	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
GFAP-Positive Reactive Astrocyte Subtype Delineation	0.518	Alzheimer's Disease	SEA-AD Gene Expression Profiling — Allen
Astrocyte-Microglia Communication Rebalancing via Cytokine M	0.490	neurodegeneration	Which cell types show the most significa
Circadian Rhythm Entrainment of Reactive Astrocytes	0.481	neurodegeneration	Astrocyte reactivity subtypes in neurode
Astrocyte APOE4-Specific Lipid Metabolism Correction	0.479	neurodegeneration	Cell type vulnerability in Alzheimers Di
Astrocyte-Mediated Neuronal Epigenetic Rescue	0.479	neurodegeneration	Epigenetic reprogramming in aging neuron
Astrocyte Metabolic Memory Reprogramming	0.478	neurodegeneration	How do astrocyte-neuron metabolic intera
Astrocyte-Mediated Microglial Memory Erasure	0.462	-	Neuroinflammation and microglial priming
Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli	0.455	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Astrocyte Metabolic Reprogramming via APOE4 Correction	0.451	neurodegeneration	Cell type vulnerability in Alzheimer's D

Mentioning Analyses (30)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell re [PMID:31488706]	Packer JS, Zhu Q, Huynh C, Sivaramakrish	Science	2019	1
Metabolic asymmetry and the global diversity of marine predators. [PMID:30679341]	Grady JM, Maitner BS, Winter AS, Kaschne	Science	2019	1
Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK [PMID:31693892]	Wang Y, An H, Liu T, Qin C, Sesaki H, Gu	Cell Rep	2019	1
AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking Sy [PMID:30057310]	Song X, Zhu S, Chen P, Hou W, Wen Q, Liu	Curr Biol	2018	1
A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)? [PMID:28224793]	Wang Z, DeWitt JC, Higgins CP, Cousins I	Environ Sci Technol	2017	1
Gene Expression by Mouse Inner Ear Hair Cells during Development. [PMID:25904789]	Scheffer DI, Shen J, Corey DP, Chen ZY	J Neurosci	2015	1
Mitochondrial dysfunction and Parkinson disease: a Parkin-AMPK alliance in neuro [PMID:26121488]	Hang L, Thundyil J, Lim KL	Ann N Y Acad Sci	2015	1
Chapter 6: Structural variation and medical genomics. [PMID:23300412]	Raphael BJ	PLoS Comput Biol	2012	1
Caffeine and adenosine. [PMID:20164566]	Ribeiro JA, Sebastião AM	J Alzheimers Dis	2010	1
De novo purine synthesis reprograms the macrophage inflammatory response and the [PMID:41756441]	Haskó G, Liu L, Németh ZH, Wagener G, Ak	Research square	2026	0
Parthenolide inhibits methamphetamine-induced depressive-like behavior by target [PMID:41795299]	Hui R, Feng T, Hou C, Xu J, Zhang R, Ji	Phytomedicine : international	2026	0
AMPKα1 Deficiency in Macrophages Impairs Tendon Regeneration and Tendon Stem Cel [PMID:41694579]	Zhu L, Wang Y, Shi X, Yu M, Cai X, Chen	International journal of biolo	2026	0
Single-cell transcriptome analysis reveals a cellular immune response in common [PMID:41692207]	Shi X, Ji G, Liu D, Zhao T, Tian S, Li S	International journal of biolo	2026	0
Farrerol ameliorates hepatic insulin resistance via AMPKα1/mTOR/SREBP-1 pathway: [PMID:41702183]	Li Y, Feng X, Zheng L	Tissue & cell	2026	0
Integration proteomics analysis to identify AMPK as key target pathways of TCM f [PMID:41788172]	Chen YJ, Ning DS, Wang CC, Zhao HW, Wang	Journal of traditional and com	2026	0
Baicalein limits subchondral bone lesions via AMPKα/BECN1 activation in osteoart [PMID:41791307]	Zhai Y, Zhou P, Dan L, Ma M, Liu B, Zhan	International immunopharmacolo	2026	0
Integrative SMR prioritizes oxidative stress-related regulatory genes for Alzhei [PMID:41844011]	Wu L, Dong YT, Mu X, Luo X, Chen ZJ	The journal of prevention of A	2026	0
Mapping the immune landscape of PCa: From tumor microenvironment to therapeutics [PMID:41956336]	Huang S, Ou Y, Zhuang W, Huang J, Wang B	Biochim Biophys Acta Rev Cance	2026	0

Astrocyte

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

CBS/PSP Supplements Guide

Atypical Parkinsonism

CBS/PSP Rehabilitation Master Guide

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

Pathway Diagram

Outgoing (2077)

Incoming (2489)

Targeting Hypotheses (21)

Mentioning Analyses (30)

How does engineered C. butyricum cross the blood-brain barrier to directly bind

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to driv

What is the optimal ketone dosing threshold to avoid metabolic steal syndrome wh

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

What specific astrocyte-derived factors can 'erase' pathological microglial memo

Do APOE4-driven senescent astrocytes cause neurodegeneration or represent a prot

APOE4-driven lipid metabolism dysregulation in astrocytes and its role in AD

Senescent cell clearance as neurodegeneration therapy

How do astrocyte-neuron metabolic interactions change during disease progression

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

Which cell types show the most significant expression changes for neurodegenerat

Immune atlas neuroinflammation analysis in neurodegeneration

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Extracellular vesicle biomarkers for early AD detection

Immune atlas neuroinflammation analysis in neurodegeneration

Mitochondrial transfer between astrocytes and neurons

Senolytic therapy for age-related neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

4R-tau strain-specific spreading patterns in PSP vs CBD

Astrocyte Reactivity Subtypes in Neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Related Papers (20)