gene 1,300 words KG: CSF2
Contents

CSF2 — Colony Stimulating Factor 2 (GM-CSF)

🧬 Gene Info
Gene SymbolCSF2
Full NameColony Stimulating Factor 2 (GM-CSF)
Chromosome5q31.1
Functionis a cytokine-encoding gene located on chromosome 5q31.
Primary Expressionvarious brain cell types including neurons, astrocytes, [microglia](/cell-types/microglia-neuroinflammati
Molecular Weight14 kDa
Amino Acids17 aa
Exons4
PathwaysAkt, IMMUNE_RESPONSE, Mapk, Pi3K, Pi3K/Akt
UniProt ID[P04141](https://www.uniprot.org/uniprot/P04141)
Ensembl IDENSG00000164400
OMIM138960
GeneCardsCSF2
Human Protein AtlasCSF2
Macrophages and MonocytesPrimary cellular sources
Associated Diseasesneurodegeneration
InteractionsIL1A, Stat3, Rb, Il-1, App, IL1B
KG Connections157 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62
APOE-Dependent Autophagy Restoration
Score: 0.61
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.43

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (5)

Packard Center for ALS Research
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
CXCL2 — C-X-C Motif Chemokine Ligand 2
gene · KG edge: associated_with
CXCL10 - C-X-C Motif Chemokine Ligand 10
gene · KG edge: regulates
CSF2RA — Colony Stimulating Factor 2 Receptor Alpha Cha
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

CSF2 biomarker_for LDLR
CSF2 regulates IMMUNE_RESPONSE
CSF2 regulates NAMPT
CSF2 regulates FGF2
CSF2 regulates CXCL10
CSF2 regulates HSPA1A
CSF2 regulates FGF8
CSF2 regulates TLR4
CSF2 regulates ISG15
CSF2 regulates STAT1