Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GNA12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | GNA12 |
| Full Name | G Protein Subunit Alpha 12 |
| Chromosome | 7p22.3 |
| Protein Family | Gq alpha subunit family |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the nervous system and participates in synaptic transmission, neuronal development, and behavioral regulation |
| Molecular Weight | ~44 kDa |
| Amino Acids | 381 aa |
| Exons | 12 |
| Pathways | MAPK Pathway |
| UniProt ID | [Q9UBF6](https://www.uniprot.org/uniprot/Q9UBF6) |
| Ensembl ID | ENSG00000156599 |
| GeneCards | GNA12 |
| Human Protein Atlas | GNA12 |
| Gene Location | Chromosome 7p22.3 |
| Associated Diseases | Als, Schizophrenia |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GNA12["<b>GNA12</b>"]
Als{"Als"}
GNA12 -->|"associated with"| Als
Schizophrenia{"Schizophrenia"}
GNA12 -->|"associated with"| Schizophrenia
neurodegeneration["neurodegeneration"]
GNA12 -->|"implicated in"| neurodegeneration
GRIN2B["GRIN2B"]
GRIN2B -->|"associated with"| GNA12
DISC1["DISC1"]
DISC1 -->|"associated with"| GNA12
GNA13["GNA13"]
GNA13 -->|"associated with"| GNA12
GNAI1["GNAI1"]
GNAI1 -->|"associated with"| GNA12
style GNA12 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | associated_with | disease | 0.65 |
| Schizophrenia | associated_with | disease | 0.65 |
| MS4A6A | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||