Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GNA13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GNA13 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, associated with, implicated in. Associated with Als, Lymphoma, Schizophrenia. Connected to 23 entities in the SciDEX knowledge graph.
| Gene Symbol | GNA13 |
| Full Name | G Protein Subunit Alpha 13 |
| Chromosome | 17q21.31 |
| Protein Family | Gq alpha subunit family |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | neurons where it participates in synaptic transmission |
| Molecular Weight | ~43 kDa |
| Amino Acids | 377 aa |
| Exons | 11 |
| UniProt ID | [Q9UQF2](https://www.uniprot.org/uniprot/Q9UQF2) |
| Ensembl ID | ENSG00000127616 |
| GeneCards | GNA13 |
| Human Protein Atlas | GNA13 |
| Gene Location | Chromosome 17q21.31 |
| Exon Count | 11 exons spanning approximately 10 kb |
| Associated Diseases | Als, Schizophrenia |
| Interactions | GJA1, ROCK2, AND |
| KG Connections | 56 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GNA13["<b>GNA13</b>"]
Lymphoma{"Lymphoma"}
GNA13 -->|"expressed in"| Lymphoma
Als{"Als"}
GNA13 -->|"expressed in"| Als
GNA13 -->|"associated with"| Als
Schizophrenia{"Schizophrenia"}
GNA13 -->|"associated with"| Schizophrenia
REL["REL"]
GNA13 -->|"expressed in"| REL
PRDM1["PRDM1"]
GNA13 -->|"expressed in"| PRDM1
Apoptosis(["Apoptosis"])
GNA13 -->|"expressed in"| Apoptosis
Nf__b(["Nf-Kappab"])
GNA13 -->|"expressed in"| Nf__b
GNAI1["GNAI1"]
GNA13 -->|"associated with"| GNAI1
GNA12["GNA12"]
GNA13 -->|"associated with"| GNA12
neurodegeneration["neurodegeneration"]
GNA13 -->|"implicated in"| neurodegeneration
CDKN2A["CDKN2A"]
CDKN2A -->|"expressed in"| GNA13
TP53["TP53"]
TP53 -->|"expressed in"| GNA13
TET2["TET2"]
TET2 -->|"expressed in"| GNA13
MYD88["MYD88"]
MYD88 -->|"expressed in"| GNA13
KMT2D["KMT2D"]
KMT2D -->|"expressed in"| GNA13
NF__B["NF-KappaB"]
NF__B -->|"expressed in"| GNA13
STAT3["STAT3"]
STAT3 -->|"expressed in"| GNA13
DDX3X["DDX3X"]
DDX3X -->|"expressed in"| GNA13
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"expressed in"| GNA13
RB1["RB1"]
RB1 -->|"expressed in"| GNA13
GRIN2B["GRIN2B"]
GRIN2B -->|"associated with"| GNA13
DISC1["DISC1"]
DISC1 -->|"associated with"| GNA13
style GNA13 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ROCK2 | interacts_with | protein | 0.80 |
| Lymphoma | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Schizophrenia | associated_with | disease | 0.65 |
| Alzheimer | biomarker_for | disease | 0.65 |
| Aging | biomarker_for | disease | 0.65 |
| REL | expressed_in | gene | 0.60 |
| PRDM1 | expressed_in | gene | 0.60 |
| GNAI1 | associated_with | gene | 0.60 |
| GNA12 | associated_with | gene | 0.60 |
| TAU | biomarker_for | gene | 0.60 |
| GJA1 | activates | gene | 0.60 |
| ROCK2 | activates | gene | 0.60 |
| PI3K | biomarker_for | gene | 0.60 |
| ROCK2 | associated_with | gene | 0.60 |
| Apoptosis | expressed_in | pathway | 0.60 |
| Nf-Κb | expressed_in | pathway | 0.60 |
| AGING | biomarker_for | gene | 0.60 |
| ALZHEIMER | biomarker_for | gene | 0.60 |
| RNA | biomarker_for | gene | 0.60 |
| MAPK | biomarker_for | gene | 0.60 |
| Mapk | biomarker_for | pathway | 0.60 |
| Amyloid | biomarker_for | pathway | 0.60 |
| Aβ | biomarker_for | protein | 0.60 |
| Akt | biomarker_for | protein | 0.60 |
| GJA1 | associated_with | gene | 0.50 |
| RNA | co_mentioned | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CDKN2A | expressed_in | gene | 0.60 |
| TP53 | expressed_in | gene | 0.60 |
| TET2 | expressed_in | gene | 0.60 |
| MYD88 | expressed_in | gene | 0.60 |
| KMT2D | expressed_in | gene | 0.60 |
| STAT3 | expressed_in | gene | 0.60 |
| DDX3X | expressed_in | gene | 0.60 |
| RB1 | expressed_in | gene | 0.60 |
| GRIN2B | associated_with | gene | 0.60 |
| DISC1 | associated_with | gene | 0.60 |
| ROCK2 | activates | gene | 0.60 |
| GJA1 | activates | gene | 0.60 |
| AKT | biomarker_for | gene | 0.60 |
| TAU | biomarker_for | gene | 0.60 |
| GJA1 | biomarker_for | gene | 0.60 |
| GJA1 | associated_with | gene | 0.60 |
| GJA1 | implicated_in | gene | 0.60 |
| NF-ΚB | expressed_in | gene | 0.60 |
| APOPTOSIS | expressed_in | gene | 0.60 |
| AGING | biomarker_for | gene | 0.60 |
| ALZHEIMER | biomarker_for | gene | 0.60 |
| MAPK | biomarker_for | gene | 0.60 |
| TAU PATHOLOGY | biomarker_for | gene | 0.60 |
| RNA | biomarker_for | gene | 0.60 |
| AND | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | biomarker_for | gene | 0.60 |
| AMYLOID | biomarker_for | gene | 0.60 |
| GJA1 | co_mentioned | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||