Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GNAI1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GNAI1 is a protein involved in neurodegeneration research. Key relationships include: interacts with, expressed in, associated with. Associated with Als, Cardiovascular, Schizophrenia. Connected to 30 entities in the SciDEX knowledge graph.
| Gene Symbol | GNAI1 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | both excitatory pyramidal neurons and inhibitory interneurons - Subcellular: Primarily plasma membrane with some cytosolic lo |
| Molecular Weight | 40.4 kDa |
| Pathways | Autophagy, Wnt, Akt |
| GeneCards | GNAI1 |
| Human Protein Atlas | GNAI1 |
| Inhibitory signaling | Inhibits adenylyl cyclase activity, reducing cAMP production |
| GTP binding and hydrolysis | Classic G protein cycle with intrinsic GTPase activity |
| Effector pathways | Inhibits AC, activates GIRK channels, modulates phospholipase C |
| Pertussis toxin sensitive | Cysteine near C-terminus is ADP-ribosylated by PTX |
| cAMP modulation | Reduced cAMP affects memory consolidation and LTP |
| GIRK activation | Opens potassium channels causing neuronal hyperpolarization |
| βγ dimers | Releases Gβγ subunits that have independent signaling functions |
| Protein-protein interactions | Multiple effector interactions beyond AC |
| Associated Diseases | Als, Schizophrenia |
| Interactions | ATG16L1, GNG2, GNAI2, NOD2, GNAS, GNAI3 |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GNAI1["<b>GNAI1</b>"]
Als{"Als"}
GNAI1 -->|"associated with"| Als
Schizophrenia{"Schizophrenia"}
GNAI1 -->|"associated with"| Schizophrenia
Cardiovascular{"Cardiovascular"}
GNAI1 -->|"expressed in"| Cardiovascular
GNA12["GNA12"]
GNAI1 -->|"associated with"| GNA12
ATG16L1["ATG16L1"]
GNAI1 -->|"interacts with"| ATG16L1
GNG2["GNG2"]
GNAI1 -->|"interacts with"| GNG2
WDR81["WDR81"]
GNAI1 -->|"expressed in"| WDR81
GNPTG["GNPTG"]
GNAI1 -->|"expressed in"| GNPTG
GNAI2["GNAI2"]
GNAI1 -->|"interacts with"| GNAI2
NOD2["NOD2"]
GNAI1 -->|"interacts with"| NOD2
GNAS["GNAS"]
GNAI1 -->|"interacts with"| GNAS
GNAI3["GNAI3"]
GNAI1 -->|"interacts with"| GNAI3
GRIN2B["GRIN2B"]
GRIN2B -->|"associated with"| GNAI1
DISC1["DISC1"]
DISC1 -->|"associated with"| GNAI1
GNA13["GNA13"]
GNA13 -->|"associated with"| GNAI1
AKT1["AKT1"]
AKT1 -->|"interacts with"| GNAI1
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"interacts with"| GNAI1
AKT["AKT"]
AKT -->|"interacts with"| GNAI1
GNB1["GNB1"]
GNB1 -->|"interacts with"| GNAI1
AMPD2["AMPD2"]
AMPD2 -->|"expressed in"| GNAI1
ATG5["ATG5"]
ATG5 -->|"interacts with"| GNAI1
MAVS["MAVS"]
MAVS -->|"interacts with"| GNAI1
TBK1["TBK1"]
TBK1 -->|"interacts with"| GNAI1
CLCN7["CLCN7"]
CLCN7 -->|"expressed in"| GNAI1
style GNAI1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| NLGN3 | mediates | protein | 0.95 |
| AKT | activates | protein | 0.90 |
| IL6 | inhibits | entity | 0.80 |
| Als | associated_with | disease | 0.65 |
| Schizophrenia | associated_with | disease | 0.65 |
| Cardiovascular | expressed_in | disease | 0.65 |
| GNA12 | associated_with | gene | 0.60 |
| ATG16L1 | interacts_with | gene | 0.60 |
| GNG2 | interacts_with | gene | 0.60 |
| WDR81 | expressed_in | gene | 0.60 |
| GNPTG | expressed_in | gene | 0.60 |
| GNAI2 | interacts_with | gene | 0.60 |
| NOD2 | interacts_with | gene | 0.60 |
| GNAS | interacts_with | gene | 0.60 |
| GNAI3 | interacts_with | gene | 0.60 |
| Autophagy | interacts_with | pathway | 0.60 |
| Wnt | expressed_in | pathway | 0.60 |
| Akt | interacts_with | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GNAI2 | downregulates | gene | 0.70 |
| GRIN2B | associated_with | gene | 0.60 |
| DISC1 | associated_with | gene | 0.60 |
| GNA13 | associated_with | gene | 0.60 |
| AKT1 | interacts_with | gene | 0.60 |
| AKT | interacts_with | gene | 0.60 |
| GNB1 | interacts_with | gene | 0.60 |
| AMPD2 | expressed_in | gene | 0.60 |
| ATG5 | interacts_with | gene | 0.60 |
| MAVS | interacts_with | gene | 0.60 |
| TBK1 | interacts_with | gene | 0.60 |
| CLCN7 | expressed_in | gene | 0.60 |
| RIPK2 | interacts_with | gene | 0.60 |
| IFIH1 | interacts_with | gene | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||