protein

GNAI2PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GNAI2PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Gαi2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	GNAI2PROTEIN
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	to the Plasma membrane, Cytoplasm
GeneCards	GNAI2PROTEIN
Human Protein Atlas	GNAI2PROTEIN
GTP-binding domain	Binds GTP/GDP and undergoes conformational changes
Helical domain	Covers the nucleotide-binding pocket
Effector-binding interface	Interacts with downstream target proteins
Gq/11	Activate phospholipase C-beta (PLCβ), leading to IP3/DAG production and calcium release
G12/13	Activate RhoGEFs, regulating cytoskeletal remodeling and cell migration
Gi/o	Inhibit adenylate cyclase and activate GIRK channels
Associated Diseases	neurodegeneration
Interactions	STIP1, KEAP1, NRF2, NOD2, GNAS, GNAI3
KG Connections	45 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Gαi2 Protein

protein · 563 words

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Pathway Diagram

graph TD
    GNAI2PROTEIN["GNAI2PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GNAI2PROTEIN -->|"implicated_in"| neurodegeneration
    style GNAI2PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found