Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GP130: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | GP130 |
| GeneCards | GP130 |
| Human Protein Atlas | GP130 |
| Associated Diseases | ALS |
| Known Drugs/Compounds | sIL-11R and sIL-6R |
| Interactions | STAT3, JAK1, IL6 |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["GP130"]
N1["STAT3"]
N0 -->|"activates"| N1
N2["IL6"]
N2 -->|"interacts with"| N0
N3["JAK1"]
N0 -->|"activates"| N3
N2 -->|"activates"| N0
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 protein
class N2 protein
class N3 protein| Source | Relation | Type | Str |
|---|---|---|---|
| IL-6 | interacts_with | protein | 0.95 |
| bazedoxifene | inhibits | drug | 0.90 |
| sIL-11R and sIL-6R | activates | compound | 0.80 |
| IL6R | activates | protein | 0.72 |
| IL11R | activates | protein | 0.72 |
| sIL6R | activates | protein | 0.72 |
| sIL11R | activates | protein | 0.72 |
| IL6 | interacts_with | protein | 0.72 |
| IL-6R | interacts_with | protein | 0.70 |
| IL6 | activates | protein | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity