Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IL-6R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | IL |
| Function | Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation. |
| GeneCards | IL |
| Human Protein Atlas | IL |
| Associated Diseases | CRC |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
IL_6R["IL-6R"]
IL_6R -->|"activates"| STAT3["STAT3"]
IL_6R -->|"mediates"| neuronal_cell_death["neuronal cell death"]
IL_6R -->|"interacts"| gp130["gp130"]
IL_6R -->|"inhibits"| COMPLEMENT["COMPLEMENT"]
IL_6R -->|"inhibits"| B_CELLS["B CELLS"]
Tocilizumab["Tocilizumab"] -->|"inhibits"| IL_6R
Satralizumab["Satralizumab"] -->|"inhibits"| IL_6R
IL_6["IL-6"] -->|"binds_to"| IL_6R
AQP4["AQP4"] -->|"inhibits"| IL_6R
CD19["CD19"] -->|"inhibits"| IL_6R| Target | Relation | Type | Str |
|---|---|---|---|
| STAT3 | activates | protein | 0.95 |
| neuronal cell death | mediates | process | 0.93 |
| gp130 | interacts_with | protein | 0.70 |
| COMPLEMENT | inhibits | pathway | 0.50 |
| B CELLS | inhibits | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Tocilizumab | inhibits | drug | 0.93 |
| IL-6 | binds_to | protein | 0.90 |
| IL-6 | interacts_with | protein | 0.70 |
| AQP4 | inhibits | gene | 0.50 |
| CD19 | inhibits | gene | 0.50 |
| IL-6 | activates | protein | 0.50 |
| DEPRESSION | associated_with | disease | 0.50 |
| IL-6 | associated_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||