protein

GRM2PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRM2PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The receptor is widely expressed throughout the brain, with high concentrations in the hippocampus, cortex, basal ganglia, and cerebellum — regions critically involved in learning, memory, and motor control[@ohishi1998].

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🔬 Protein Info

Gene Symbol	GRM2PROTEIN
Full Name	mGluR2 — Glutamate Metabotropic Receptor 2
Protein Type	Protein
Function	is a member of the group I metabotropic glutamate receptor family that plays a critical role in modulating excitatory glutamatergic neurotransmission in the central nervous system[@pin2009].
Primary Expression	presynaptic terminals throughout the central nervous system, where it serves as an autoreceptor regulating glutamate release[@shaban2006]
UniProt ID	Search UniProt
GeneCards	GRM2PROTEIN
Human Protein Atlas	GRM2PROTEIN
Associated Diseases	Als, Alzheimer, Inflammation, Neuroinflammation, Ptsd
Interactions	adcy2, ADCY2, ALZHEIMER, ALZHEIMER'S DISEASE, ASTROCYTE, C3AR1
KG Connections	103 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GRM2PROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

mGluR2 Protein — Glutamate Metabotropic Receptor 2

protein · 2220 words

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Pathway Diagram

graph TD
    GRM2PROTEIN["GRM2PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GRM2PROTEIN -->|"implicated_in"| neurodegeneration
    style GRM2PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GRM2PROTEIN in their description or question text

No additional research found