protein

UGCG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UGCG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

2Analyses

22Outgoing

8Incoming

0Experiments

2Debates

Summary

Page for UGCG Protein (UDP-Glucose Ceramide Glucosyltransferase)

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🔬 Protein Info

Gene Symbol	UGCG
Aliases	UDP-Glucose Ceramide Glucosyltransferase
Function	The UGCG gene encodes UDP-glucose ceramide glucosyltransferase (UGCG), also known as glucosylceramide synthase.
Primary Expression	glial cells including astrocytes and oligodendrocytes
Subcellular Localization	the Golgi apparatus where it transfers glucose from UDP-glucose to ceramide. Dysregulation of glycosphingolipid metaboli
Molecular Weight	46 kDa
Pathways	Apoptosis, Nf-Κb, Oxidative Stress, Wnt, apoptosis pathway
Ensembl ID	ENSG00000165269
GeneCards	UGCG
Human Protein Atlas	UGCG
Associated Diseases	Als
Interactions	APOPTOSIS, CD63, CD9, ERK, OXIDATIVE STRESS, RAB35
KG Connections	30 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

UGCG Gene

gene · 561 words

→

UGCG Protein (UDP-Glucose Ceramide Glucosyltransferase)

protein · 748 words

→

Pathway Diagram

graph TD
    UGCG["UGCG"]
    Heart_Failure{"Heart Failure"}
    UGCG -->|"activates"| Heart_Failure
    Als{"Als"}
    UGCG -->|"interacts with"| Als
    Sphingolipid(["Sphingolipid"])
    UGCG -->|"associated with"| Sphingolipid
    Oxidative_Stress(["Oxidative Stress"])
    UGCG -->|"activates"| Oxidative_Stress
    neurodegeneration["neurodegeneration"]
    UGCG -->|"implicated in"| neurodegeneration
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"activates"| UGCG
    ERK["ERK"]
    ERK -->|"activates"| UGCG
    style UGCG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (22)

Target	Relation	Type	Str
glucosylceramide	synthesizes	lipid	0.90
Glucosylceramide	causes	drug	0.70
Cancer	activates	disease	0.65
Heart Failure	activates	disease	0.65
Als	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Apoptosis	activates	pathway	0.60
Lysosomal Degradation	inhibits	pathway	0.60
STING	activates	gene	0.60
Lipid Metabolism	inhibits	pathway	0.60
TSG101	activates	gene	0.60
EXOSOMES	associated_with	gene	0.60
Epithelial	associated_with	cell_type	0.60
Lipid Metabolism	contributes_to	pathway	0.60
App	associated_with	protein	0.60
apoptosis pathway	participates_in	pathway	0.60
Autophagy	inhibits	pathway	0.60
RAB5	activates	gene	0.60
Sphingolipid	associated_with	pathway	0.60
Oxidative Stress	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
Wnt	activates	pathway	0.60

Incoming (8)

Source	Relation	Type	Str
TFEB	upregulates	transcription_factor	0.70
CD9	activates	gene	0.60
RAB35	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
CD63	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
RNA	inhibits	gene	0.60
ERK	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Does TFEB activation directly restore mutant GBA enzyme activity or only enhance

molecular biology | 2026-04-11 | 0 hypotheses

GBA-Synuclein Loop Therapeutics for PD

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.525

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The debate identified this as a critical mechanistic gap - TFEB may increase lys

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

How to break the GBA-alpha-synuclein bidirectional loop for Parkinson's Disease

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

Related Research

Hypotheses and analyses mentioning UGCG in their description or question text

No additional research found