Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about H3K27Ac: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| h-8af27bf934 | targeted_by | hypothesis | 1.00 |
| MMP9 | regulates | gene | 0.85 |
| transcription | regulates | process | 0.70 |
| Alzheimer's disease | associated_with | disease | 0.70 |
| neurodegeneration | activates | process | 0.70 |
| BRD4 recruitment to enhancers | regulates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-8af27bf934 | targets | hypothesis | 1.00 |
| Rgfp966 | upregulates | drug | 0.88 |
| RGFP966 | upregulates | drug | 0.85 |
| AKT | associated_with | protein | 0.80 |
| MTOR | associated_with | protein | 0.80 |
| BRD4 recruitment | requires | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| NLRP3 Inflammasome Chromatin Priming Through H3K27ac Accumul | 0.566 | developmental-neurobiology | Do perinatal immune challenges create pe |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.770
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning H3K27Ac in their description or question text
No additional research found