TRANSCRIPTION

The abstract reveals FUS has a chaperone-like function regulating TAZ condensate

closed · Rounds: 4 · Score: 0.81 · 2026-04-16

APOE ε4-driven microglial lipid handling as proximal driver in Non-Neuronal Tran

Score: 0.626 · neurodegeneration · 2026-04-28

APOE ε4-driven microglial lipid handling should produce a measurable proximal phenotype before late disease pathology. T

ATF4-DDIT3 stress signaling indirectly represses MAPT transcription during prote

Score: 0.624 · neurodegeneration · 2026-04-25

Integrated stress response factors redirect transcription and chromatin regulation away from tau expression during acute

Cell-state stratification is required to resolve Non-Neuronal Transcriptional Ch

Score: 0.612 · neurodegeneration · 2026-04-28

The question is likely underpowered or misleading unless analyses preserve the key strata: RNA-, APOE. Averaging across

H2: H3K9me3 Heterochromatin Collapse Enables Cryptic Transcription of Repetitive

Score: 0.610 · neurodegeneration · 2026-04-22

## Mechanistic Overview H2: H3K9me3 Heterochromatin Collapse Enables Cryptic Transcription of Repetitive Elements starts

Perturbation-first validation should precede therapeutic claims for Non-Neuronal

Score: 0.608 · neurodegeneration · 2026-04-28

The debate supports treating this as a validation program before ranking it as a therapy. Perturbation should move a pro

HSF1 reprioritizes transcription and suppresses MAPT while restoring proteostasi

Score: 0.598 · neurodegeneration · 2026-04-25

Heat-shock signaling either directly or indirectly reduces tau expression as chaperone programs dominate the stress resp

Direct NF-κB Transcriptional Regulation of C1q Genes in Microglia

Score: 0.570 · neuroinflammation · 2026-04-21

## Mechanistic Overview Direct NF-κB Transcriptional Regulation of C1q Genes in Microglia starts from the claim that mod

Astrocytic SPP1 Modulation Through STAT3-Dependent Transcriptional Control

Score: 0.551 · neuroinflammation · 2026-04-20

## Mechanistic Overview Astrocytic SPP1 Modulation Through STAT3-Dependent Transcriptional Control starts from the claim

CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macrophages, Triggering

Score: 0.535 · neurodegeneration · 2026-04-22

## Mechanistic Overview CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macrophages, Triggering NF-κB-Dependent

Epigenetic CRISPR/dCas9 Activation of PV Gene Program Prevents Aβ-Induced Transc

Score: 0.525 · alzheimers · 2026-04-28

Aβ triggers DNA methylation of the Pvalb promoter via DNMT3A upregulation, silencing PV expression and GAD1/GAD2 GABA sy

miR-143/145 Cluster Dysregulation Derepresses P2RY12 Transcription

Score: 0.520 · neurodegeneration · 2026-04-21

## Mechanistic Overview miR-143/145 Cluster Dysregulation Derepresses P2RY12 Transcription starts from the claim that mo

Hippocampus ages transcriptionally faster than cerebellum, defining a regional v

Score: 0.516 · alzheimers · 2026-04-23

## Mechanistic Overview Hippocampus ages transcriptionally faster than cerebellum, defining a regional vulnerability axi

PKM2 nuclear translocation bridges metabolism and inflammatory transcription in

Score: 0.506 · neuroinflammation · 2026-04-21

## Mechanistic Overview PKM2 nuclear translocation bridges metabolism and inflammatory transcription in primed microglia

Early Postnatal TGF-beta Signaling Establishes Lifelong Regional Vulnerability T

Score: 0.500 · neuroinflammation · 2026-04-22

## Mechanistic Overview Early Postnatal TGF-beta Signaling Establishes Lifelong Regional Vulnerability Through Irreversi

YAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1 Transcription in Pe

Score: 0.492 · neurodegeneration · 2026-04-22

## Mechanistic Overview YAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1 Transcription in Perivascular Fibro