Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HCRTR1/HCRTR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | promoted: Circadian Glymphatic Entrainment via Targeted Orexin Receptor Modulation | disease | 0.60 |
| neurodegeneration | associated_with | disease | 0.50 |
| KCNK2 | debate_co_mention | gene | 0.45 |
| LOX | debate_co_mention | gene | 0.45 |
| LOX/LOXL1-4 | debate_co_mention | gene | 0.45 |
| PDGFRB | debate_co_mention | gene | 0.45 |
| KCNK2 | co_associated_with | gene | 0.40 |
| SDC1 | co_associated_with | gene | 0.40 |
| LOX/LOXL1-4 | co_associated_with | gene | 0.40 |
| PDGFRB | co_associated_with | gene | 0.40 |
| benchmark_ot_ad_answer_key:HCRTR1/HCRTR2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Circadian Glymphatic Entrainment via Targeted Orexin Recepto | 0.623 | neurodegeneration | Perivascular spaces and glymphatic clear |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.623
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake [PMID:40439868] | Zheng Z, Xue F, Wang H, Gu Q, Hu R, Li X | Pharmacol Rep | 2025 | 1 |
| Genetic determinants of daytime napping and effects on cardiometabolic health. [PMID:33568662] | Dashti HS, Daghlas I, Lane JM, Huang Y, | Nat Commun | 2021 | 1 |
| Hypocretin/Orexin Receptor Pharmacology and Sleep Phases. [PMID:34052813] | Sun Y, Tisdale RK, Kilduff TS | Front Neurol Neurosci | 2021 | 1 |
| Sleep drives metabolite clearance from the adult brain. [PMID:24136970] | Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th | Science | 2013 | 1 |
| Signal transduction, dimerization, and therapeutic targeting of Orexin and recep [PMID:41383480] | Zhang S, Wang P, Ji B, Shao Y, Hou S et | Front Pharmacol | 2025 | 0 |
| Bioinformatic analysis of neuropeptide related genes in patients diagnosed with [PMID:39437604] | Yay F, Ayan D | Comput Biol Med | 2024 | 0 |
| Effects of Paradoxical Sleep Deprivation on MCH and Hypocretin Systems. [PMID:39698172] | Agamme ALDA, Tufik S, Torterolo P, D'Alm | Sleep science (Sao Paulo, Braz | 2024 | 0 |
| Blast Exposure Induces Acute Alterations in Circadian Clock Genes in the Hypotha [PMID:41127649] | Govindarajulu M, Patel MY, Krishnan J, L | Neurotrauma reports | 2023 | 0 |
| Contextual generalization of social stress learning is modulated by orexin recep [PMID:35724928] | Yaeger JDW, Krupp KT, Summers TR, Summer | Neuropharmacology | 2022 | 0 |
| Evaluation of the α-casein (CSN1S1) locus as a potential target for a site-speci [PMID:35568783] | ["Smirnov A", "Kontsevaya G", "Shnaider | Scientific reports | 2022 | 0 |
| Outcomes of a telemedicine bowel management program during COVID-19. [PMID:34686377] | ["Knaus M", "Ahmad H", "Metzger G", "Bey | Journal of pediatric surgery | 2022 | 0 |
| Sleep interventions in AD trials show inconsistent cognitive benefits, possibly [PMID:33661831] | Unknown | Sleep Medicine Reviews | 2021 | 0 |
| Machine learning for clinical decision support in infectious diseases: a narrati [PMID:31539636] | ["Peiffer-Smadja N", "Rawson T", "Ahmad | Clinical microbiology and infe | 2020 | 0 |
| Complexities of Understanding Function from CKD-Associated DNA Variants. [PMID:32513823] | ["Lin J", "Susztak K"] | Clinical journal of the Americ | 2020 | 0 |
| Prostaglandin D [PMID:30513028] | ["Marone G", "Galdiero M", "Pecoraro A", | Expert opinion on investigatio | 2019 | 0 |
| CF-PA [PMID:31852950] | ["Morishita R", "Sugiyama S", "Denda M", | Scientific reports | 2019 | 0 |
| Transitions from Single- to Multi-Locus Processes during Speciation with Gene Fl [PMID:29795050] | ["Schilling M", "Mullen S", "Kronforst M | Genes | 2018 | 0 |
| Co-occurring expression and methylation QTLs allow detection of common causal va [PMID:29476079] | ["Pierce B", "Tong L", "Argos M", "Deman | Nature communications | 2018 | 0 |
| T-Cell Mediation of Pregnancy Analgesia Affecting Chronic Pain in Mice. [PMID:28877966] | ["Rosen S", "Ham B", "Drouin S", "Boachi | The Journal of neuroscience : | 2017 | 0 |
| Pentylenetetrazol-induced seizures are exacerbated by sleep deprivation through [PMID:23852314] | Ni LY, Zhu MJ, Song Y, Liu XM, Tang JY | Neurol Sci | 2014 | 0 |