Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HSPBP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | HSPBP1 |
| Protein Type | Chaperone |
| Function | HSPBP1 (Hsp70 Binding Protein 1), also known as FISP1 (Hsp70-interacting protein), is a co-chaperone that modulates Hsp70 family protein function. |
| Primary Expression | various cancers |
| Ensembl ID | ENSG00000066501 |
| GeneCards | HSPBP1 |
| Human Protein Atlas | HSPBP1 |
| J-domain containing protein | Activates Hsp70 ATPase activity |
| Protein folding assistance | Facilitates Hsp70-mediated protein folding |
| Protein quality control | Targets misfolded proteins for degradation |
| Stress response | Modulates cellular stress responses |
| Anti-apoptotic function | Protects cells from stress-induced death |
| Associated Diseases | neurodegeneration |
| Interactions | BAG1, DNAJB6, HSP70, HSPA1A, HSPA8, ATP |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HSPBP1["HSPBP1"]
style HSPBP1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
ATP(["ATP"])
BAG1["BAG1"]
DNAJB6["DNAJB6"]
HSP40(["HSP40"])
HSP70(["HSP70"])
HSPA1A(["HSPA1A"])
HSPA8["HSPA8"]
neurodegeneration["neurodegeneration"]
ATP -->|"interacts_with"| HSPBP1
BAG1 -->|"interacts_with"| HSPBP1
DNAJB6 -->|"interacts_with"| HSPBP1
HSP40 -->|"interacts_with"| HSPBP1
HSP70 -->|"interacts_with"| HSPBP1
HSPA1A -->|"interacts_with"| HSPBP1
HSPA8 -->|"interacts_with"| HSPBP1
HSPBP1 -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class ATP protein
class BAG1 gene
class DNAJB6 gene
class HSP40 protein
class HSP70 protein
class HSPA1A protein
class HSPA8 gene
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||