gene 673 words KG: HSPBP1
Contents

HSPBP1

🧬 Gene Info
Gene SymbolHSPBP1
Protein TypeChaperone
FunctionHSPBP1 (Hsp70 Binding Protein 1), also known as FISP1 (Hsp70-interacting protein), is a co-chaperone that modulates Hsp70 family protein function.
Primary Expressionvarious cancers
Ensembl IDENSG00000066501
GeneCardsHSPBP1
Human Protein AtlasHSPBP1
J-domain containing proteinActivates Hsp70 ATPase activity
Protein folding assistanceFacilitates Hsp70-mediated protein folding
Protein quality controlTargets misfolded proteins for degradation
Stress responseModulates cellular stress responses
Anti-apoptotic functionProtects cells from stress-induced death
Associated Diseasesneurodegeneration
InteractionsATP, BAG1, DNAJB6, HSP40, HSP70, HSPA1A
KG Connections7 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (12)

Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
APOE-Dependent Autophagy Restoration
Score: 0.89
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.54
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (7 edges)

BAG1 interacts_with HSPBP1
DNAJB6 interacts_with HSPBP1
HSP70 interacts_with HSPBP1
HSPA1A interacts_with HSPBP1
HSPA8 interacts_with HSPBP1
ATP interacts_with HSPBP1
HSP40 interacts_with HSPBP1

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