protein

HSP40

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSP40: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

0Hypotheses

0Analyses

31Outgoing

17Incoming

Summary

Page for Hsp40 Protein

View on Wiki →

🔬 Protein Info

Gene Symbol	HSP40
Molecular Weight	80 kDa
Amino Acids	70 aa
Pathways	unfolded protein response, Chaperone
GeneCards	HSP40
Human Protein Atlas	HSP40
Associated Diseases	ALS, Neurodegenerative Diseases, dementia, disease, frontotemporal, neurodegeneration
Interactions	HSP70, HSPA1A, HSPA8, HSPH1, RNA, TDP-43
KG Connections	48 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HSP40("HSP40")
    AMYLOID["AMYLOID"]
    HSP40 -->|"inhibits"| AMYLOID
    Chaperone(["Chaperone"])
    HSP40 -->|"inhibits"| Chaperone
    HSP40 -->|"regulates"| Chaperone
    Proteostasis["Proteostasis"]
    HSP40 -->|"regulates"| Proteostasis
    Neurodegenerative_Diseases{"Neurodegenerative Diseases"}
    HSP40 -->|"associated_with"| Neurodegenerative_Diseases
    disease{"disease"}
    HSP40 -->|"associated_with"| disease
    HSP40 -->|"associated_with"| Chaperone
    Proteins("Proteins")
    HSP40 -->|"associated_with"| Proteins
    DNAJB6["DNAJB6"]
    DNAJB6 -->|"inhibits"| HSP40
    DNAJB6 -->|"interacts_with"| HSP40
    DNAJC5["DNAJC5"]
    DNAJC5 -->|"associated_with"| HSP40

Outgoing (31)

Target	Relation	Type	Str
HSP70	activates	gene	0.85
HSPA1A	activates	gene	0.65
HSP70	interacts_with	gene	0.65
HSP70	associated_with	gene	0.65
ALS	associated_with	disease	0.60
dementia	associated_with	disease	0.60
frontotemporal	associated_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
HSPA8	activates	gene	0.55
HSPH1	activates	gene	0.55
TDP-43	associated_with	gene	0.55
RNA	interacts_with	gene	0.55
TDP-43	interacts_with	gene	0.55
HSPH1	interacts_with	gene	0.55
HSPA1A	interacts_with	gene	0.55
HSPA8	interacts_with	gene	0.55
HSPBP1	interacts_with	gene	0.55
tauopathy	activates	disease	0.55
HSPA1B	activates	gene	0.55
TDP-43	activates	gene	0.55
unfolded protein response	participates_in	pathway	0.55
AMYLOID	inhibits	gene	0.50
Chaperone	inhibits	pathway	0.50
Chaperone	regulates	pathway	0.50
Proteostasis	regulates	process	0.50
Neurodegenerative Diseases	associated_with	disease	0.50
disease	associated_with	disease	0.50
Chaperone	associated_with	pathway	0.50
Proteins	associated_with	protein	0.50
HSP70	co_expressed_with	protein	0.50
HSPA1A	co_expressed_with	protein	0.50

Incoming (17)

Source	Relation	Type	Str
DNAJB1	activates	gene	0.75
DNAJA1	activates	gene	0.65
ATP	interacts_with	gene	0.65
HSP110	regulates	gene	0.60
HSC70	activates	gene	0.55
HSP110	activates	gene	0.55
HSP110	interacts_with	gene	0.55
DNAJB1	interacts_with	gene	0.55
APOE4	activates	gene	0.55
DNAJB6	associated_with	gene	0.55
BAG1	interacts_with	gene	0.55
DNMT1	activates	gene	0.55
DNAJB6	inhibits	gene	0.50
DNAJB6	interacts_with	gene	0.50
DNAJC5	associated_with	gene	0.50
CHIP	co_expressed_with	protein	0.50
HSC70	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HSP40

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

ftd-tdp-pathology

Prion vs Tau/Alpha-Synuclein Propagation: Mechanistic Comparison

Neuronal Ceroid Lipofuscinosis (NCL)

Amyloid-beta Fibril Formation Pathway

SNCA→Alpha-synuclein→Aggregation→Lewy Bodies→Synucleinopathies Causal Chain

Alpha-Synuclein ESCRT-III Inhibition Mechanism

Alpha-Synuclein Aggregation Pathway

DNAJC13 — DnaJ Heat Shock Protein Family Member C13

Proteostasis Network Dysfunction Comparison Across Neurodegenerative Diseases

Alpha-Synuclein Propagation Mechanism

Heat Shock Protein Response Pathway in Neurodegeneration

Shared Proteinostasis Failure in Alzheimer's and Parkinson's Disease

Iduna Therapeutics

SOD1 — Superoxide Dismutase 1

SOD1 Superoxide Dismutase 1 ALS Causal Chain

Protein Quality Control in Neurodegeneration

Tau Proteostasis and Clearance Across 4R-Tauopathies