gene

il1rap

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about il1rap: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

3Outgoing

4Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	IL1RAP
Full Name	Interleukin-1 receptor accessory protein
Chromosome	3q28
Protein Type	Receptor
Function	is a critical coreceptor for the interleukin-1 receptor family, essential for IL-1 signaling cascade activation.
Primary Expression	Microglia, Astrocytes, Spleen, Liver, Bone Marrow
Amino Acids	570 aa
Exons	12
UniProt ID	Q9NPH8
NCBI Gene ID	3556
Ensembl ID	ENSG00000124788
OMIM	602463
GeneCards	IL1RAP
Human Protein Atlas	IL1RAP
Extracellular domain	Three immunoglobulin-like domains responsible for ligand binding and interaction with IL1R1/IL1R2
Associated Diseases	Alzheimer's Disease, Multiple Sclerosis, Glioma
Databases	GeneCards HPA STRING

🔮 Predicted Structure: il1rap — AlphaFold Q9NPH8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IL1RAP — Interleukin-1 receptor accessory protein

gene · 3150 words

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Pathway Diagram

flowchart TD
    IL1RAP["IL1RAP"] -->|"expressed in"| TREM2["TREM2"]
    IL1RAP["IL1RAP"] -->|"expressed in"| microglia["microglia"]
    IL1RAP["IL1RAP"] -->|"implicated in"| neurodegeneration["neurodegeneration"]
    APOE["APOE"] -->|"expressed in"| IL1RAP["IL1RAP"]
    CD33["CD33"] -->|"expressed in"| IL1RAP["IL1RAP"]
    GRN["GRN"] -->|"expressed in"| IL1RAP["IL1RAP"]
    style IL1RAP fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style TREM2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style microglia fill:#00695c,stroke:#333,color:#e0e0e0
    style neurodegeneration fill:#006494,stroke:#333,color:#e0e0e0
    style APOE fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style CD33 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style GRN fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (3)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:IL1RAP	data_in	dataset_row	0.00
TREM2	expressed_in	gene	0.60
microglia	expressed_in	cell_type	0.55

Incoming (4)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:IL1RAP	data_in	dataset_row	0.00
APOE	expressed_in	gene	0.60
CD33	expressed_in	gene	0.60
GRN	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning il1rap in their description or question text

No additional research found