gene

GRN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

805Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Gene profile: GRN - Progranulin gene in FTD and NCL

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🧬 Gene Info

Gene Symbol	GRN
Aliases	Gene profile: GRN
Chromosome	17q21.31
Protein Family	Granulin family
Function	Each granulin domain is approximately 90 amino acids with 12 conserved cysteine residues forming 6 disulfide bonds, creating a compact, stable structure[3].
Primary Expression	Cerebral cortex, Hippocampus, Microglia, Substantia nigra
Subcellular Localization	Secreted; also localizes to lysosomes
Molecular Weight	~90 kDa (secreted); 68 kDa (granulin domain)
Amino Acids	593 aa
Pathways	Autophagy, Immune Response
UniProt ID	P28799
Ensembl ID	ENSG00000030582
GeneCards	GRN
Human Protein Atlas	GRN
Associated Diseases	ALS, ALZHEIMER'S DISEASE, Aging, Alzheimer
Interactions	CTSB, SPP1, NFL, C1QA, C9ORF72, APOE
KG Connections	805 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GRN — AlphaFold P28799 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GRN["GRN"]
    GRN -->|"encodes"| progranulin["progranulin"]
    GRN -->|"regulates"| microglia["microglia"]
    GRN -->|"inhibits"| aberrant_microglia_activation["aberrant microglia activation"]
    GRN -->|"causes"| lysosomal_dysfunction["lysosomal dysfunction"]
    GRN -->|"activates"| Alzheimer["Alzheimer"]
    GRN -->|"activates"| Dementia["Dementia"]
    GRN -->|"activates"| Als["Als"]
    GRN -->|"target for"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    CTSB["CTSB"] -->|"activates"| GRN
    C1QA["C1QA"] -->|"activates"| GRN
    SPP1["SPP1"] -->|"activates"| GRN
    C9ORF72["C9ORF72"] -->|"target for"| GRN
    GENES["GENES"] -->|"target for"| GRN
    DNA["DNA"] -->|"activates"| GRN
    FUS["FUS"] -->|"target for"| GRN
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| GRN
    ACE["ACE"] -->|"target for"| GRN

Outgoing (517)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Frontotemporal Lobar Degeneration	risk_factor_for	disease	0.95
Neuronal ceroid lipofuscinosis	causes	disease	0.95
Lysosomal Function	involved_in	process	0.95
Frontotemporal Dementia	risk_factor_for	disease	0.95
Astrocyte Toxicity	mediates	mechanism	0.90
microglial inflammatory response	suppresses	process	0.85
Alzheimer Disease	risk_factor_for	disease	0.85
Neuroinflammation	regulates	process	0.85
Disease Pathogenesis	involved_in	process	0.80
neuronal ceroid lipofuscinosis	causes	disease	0.80
frontotemporal dementia	causes	disease	0.80
TAR	interacts_with	gene	0.80
FTLD	implicated_in	disease	0.80
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.75
Dementia	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Dementia	causes	disease	0.75
Neurodegeneration	therapeutic_target	disease	0.75
progranulin	encodes	protein	0.70
frontotemporal lobar degeneration	associated_with	disease	0.70
aberrant microglia activation	inhibits	process	0.70
lysosomal dysfunction	causes	process	0.70
schizophrenia	associated_with	disease	0.70
neurodegeneration	interacts_with	disease	0.70
neurodegeneration	regulates	disease	0.70
frontotemporal dementia	associated_with	disease	0.70
microglia	regulates	cell_type	0.70
microglia	expressed_in	cell_type	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
Alzheimer's disease	causes	disease	0.70
Parkinson's disease	causes	disease	0.70
RNA	associated_with	gene	0.70
neuroinflammation	co_discussed	concept	0.65
autophagy	co_discussed	concept	0.65
TFEB	co_discussed	gene	0.65
TBK1	co_discussed	gene	0.65
OPTN	co_discussed	gene	0.65
SQSTM1	co_discussed	gene	0.65
VCP	co_discussed	gene	0.65
TYROBP	activates	gene	0.65
TAU	exacerbates	protein	0.65
TDP-43	increases_risk	protein	0.65
TDP-43	causes	protein	0.65
TDP-43	regulates	protein	0.65
NEURONAL CEROID LIPOFUSCINOSIS	encodes	disease	0.65
TDP-43	phosphorylates	gene	0.65
TFEB	produces	gene	0.65

Incoming (288)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
SPP1	upregulates	gene	0.90
GPNMB	associated_with	gene	0.80
DNA	interacts_with	gene	0.80
GENES	therapeutic_target	gene	0.70
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.70
NEURODEGENERATION	therapeutic_target	gene	0.70
FTLD	regulates	gene	0.70
CLU	associated_with	gene	0.65
FUS	co_discussed	gene	0.65
TMEM106B	increases_risk	gene	0.65
TMEM106B	causes	gene	0.65
TREM2	interacts_with	gene	0.65
TREM2	treats	gene	0.65
ASTROCYTE	associated_with	gene	0.65
FRONTOTEMPORAL DEMENTIA	causes	disease	0.65
NEURONS	activates	cell_type	0.65
LYSOSOMAL DYSFUNCTION	treats	phenotype	0.65
NEURON	treats	cell_type	0.65
CORTEX	treats	brain_region	0.65
DEMENTIA	interacts_with	disease	0.65
CTSB	activates	gene	0.60
C1QA	activates	gene	0.60
SPP1	activates	gene	0.60
C9ORF72	therapeutic_target	gene	0.60
CTSD	associated_with	gene	0.60
C9ORF72	activates	gene	0.60
FUS	therapeutic_target	gene	0.60
CTSB	co_discussed	gene	0.60
C9ORF72	associated_with	gene	0.60
FUS	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
CTSH	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
SIGLEC9	associated_with	gene	0.60
SIRPA	associated_with	gene	0.60
ACE	therapeutic_target	gene	0.60
TREM2	therapeutic_target	gene	0.60
PILRA	therapeutic_target	gene	0.60
IDUA	therapeutic_target	gene	0.60
TAU	therapeutic_target	gene	0.60
MAPT	associated_with	gene	0.60
C9ORF72	protects_against	gene	0.60
C9ORF72	causes	gene	0.60
FUS	causes	gene	0.60
SOD1	expressed_in	gene	0.60
TAU	causes	gene	0.60
GATA2	regulates	gene	0.60
TP53	regulates	gene	0.60
EGFR	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GRN

Understanding Entity Pages

Summary

Wiki Pages (21)

GRN (Redirect)

Corticobasal Syndrome (CBS)

Novel Therapy Index

primary-progressive-aphasia

Atypical Parkinsonism

Corticobasal Degeneration (CBD)

Frontotemporal Dementia (FTD) Mechanistic Pathway

Frontotemporal Dementia (FTD)

Microglial Cells — Cell Type Hierarchy

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

oxidative-stress-comparison

ftd-tdp-pathology

Mitophagy Pathway in Neurodegeneration

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

rankings

Tau Strain Diversity and Conformational Templating in Tauopathies

deferiprone-neurodegeneration

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

Neuronal Ceroid Lipofuscinosis (NCL)