gene 3,150 words KG: IL1RAP
Contents

IL1RAP — Interleukin-1 receptor accessory protein

🧬 Gene Info
Gene SymbolIL1RAP
Full NameInterleukin-1 receptor accessory protein
Chromosome3q28
Protein TypeReceptor
Functionis a critical coreceptor for the interleukin-1 receptor family, essential for IL-1 signaling cascade activation.
Primary ExpressionMicroglia, Astrocytes, Spleen, Liver, Bone Marrow
Amino Acids570 aa
Exons12
UniProt IDQ9NPH8
NCBI Gene ID3556
Ensembl IDENSG00000124788
OMIM602463
GeneCardsIL1RAP
Human Protein AtlasIL1RAP
Associated DiseasesAlzheimer's Disease, Multiple Sclerosis, Glioma
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (15)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51

Related Analyses (9)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

See Also (15)

UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 9 hypotheses
remternetug-anti-amyloid-alzheimers
clinical_trial · Pages share 9 hypotheses
nct05508789
clinical_trial · Pages share 9 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 9 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 9 hypotheses

Knowledge Graph (7 edges)

IL1RAP expressed_in TREM2
IL1RAP expressed_in microglia
IL1RAP data_in benchmark_ot_ad_answer_key:IL1RAP
APOE expressed_in IL1RAP
CD33 expressed_in IL1RAP
GRN expressed_in IL1RAP
benchmark_ot_ad_answer_key:IL1RAP data_in IL1RAP