gene

CD33

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD33: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

657Connections

2Hypotheses

5Analyses

50Outgoing

50Incoming

0Experiments

8Debates

Summary

A gene referenced in 1 knowledge graph relationship. Key connections: inhibits phagocytosis (mechanism).

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🧬 Gene Info

Gene Symbol	CD33
Full Name	Cluster of Differentiation 33
Aliases	Siglec-3
Chromosome	19q13.41
Function	Sialic acid binding: Recognizes α2,6-linked sialic acids on glycoproteins
Molecular Weight	67 kDa
Amino Acids	354 aa
Exons	7
Pathways	Apoptosis, Autophagy, Blood-Brain Barrier, Dysbiosis, Epigenetic
UniProt ID	[P20138](https://www.uniprot.org/uniprot/P20138)
GeneCards	CD33
Human Protein Atlas	CD33
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	Stem Cell Therapy
Interactions	ABCA7, Actin, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID
SciDEX Hypotheses	CD33-Dependent Switch Hypothesis: CD33 Antagonism CD33-Sialic Acid Pathway Modulation in Microglia
KG Connections	657 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CD33["CD33"]
    CD33 -->|"interacts"| Als["Als"]
    CD33 -->|"interacts"| Tauopathy["Tauopathy"]
    CD33 -->|"inhibits"| Leukemia["Leukemia"]
    CD33 -->|"inhibits"| Ms["Ms"]
    CD33 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    CD33 -->|"target for"| Alzheimer["Alzheimer"]
    CD33 -->|"target for"| Neuroinflammation["Neuroinflammation"]
    CD33 -->|"target for"| Inflammation["Inflammation"]
    TYROBP["TYROBP"] -->|"interacts"| CD33
    APP["APP"] -->|"interacts"| CD33
    PSEN1["PSEN1"] -->|"interacts"| CD33
    BCL2["BCL2"] -->|"inhibits"| CD33
    MICROGLIA["MICROGLIA"] -->|"interacts"| CD33
    NEURODEGENERATION["NEURODEGENERATION"] -->|"target for"| CD33
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| CD33

Outgoing (481)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CD33	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Alzheimer Disease	risk_factor_for	disease	0.90
T cells	expressed_in	cell_type	0.90
microglia	associated_with	cell_type	0.90
Microglial Function	modulates	process	0.85
Alzheimer's Disease	risk_factor_for	disease	0.85
Microglial Activation	regulates	process	0.85
Amyloid-Beta Clearance	regulates	process	0.85
Amyloid Pathology	involved_in	process	0.85
Microglial Phagocytosis of Amyloid-β	involved_in	process	0.85
neuroinflammation	activates	disease	0.80
Alzheimer's disease	biomarker_for	disease	0.80
Aβ pathology	inhibits	disease	0.80
microglial activation	regulates	process	0.80
macrophages	expressed_in	cell_type	0.80
oxidative stress response	participates_in	pathway	0.80
Als	therapeutic_target	disease	0.75
Alzheimer	associated_with	disease	0.75
amyloid-beta clearance	modulates	process	0.75
Als	activates	disease	0.75
Leukemia	therapeutic_target	disease	0.75
Alzheimer	regulates	disease	0.75
Alzheimer's disease	causes	disease	0.70
ALZHEIMER	regulates	gene	0.70
Parkinson's disease	causes	disease	0.70
TREM2	inhibits	protein	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
phagocytosis	activates	process	0.70
TREM2	associated_with	gene	0.70
CLU	regulates	gene	0.70
PSEN2	regulates	gene	0.70
neuroinflammation	associated_with	disease	0.70
ALZHEIMER	associated_with	gene	0.70
GPNMB	causes	gene	0.70
MICROGLIA	associated_with	gene	0.70
stem cells	expressed_in	cell_type	0.70
HLA	regulates	gene	0.70
Alzheimer's disease	interacts_with	disease	0.70
synaptic pruning	associated_with	phenotype	0.70
cytokine production	inhibits	mechanism	0.70
microglial amyloid clearance	inhibits	process	0.70
microglial immune responses	modulates	mechanism	0.70
TYROBP	modulates	protein	0.70
monocyte activation	regulates	process	0.70
Als	interacts_with	disease	0.65
PHAGOCYTOSIS	associated_with	phenotype	0.65
Neurodegeneration	activates	disease	0.65
TNF	regulates	gene	0.65
TREM2	increases_risk	gene	0.65

Incoming (176)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CD33	data_in	dataset_row	0.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
ds-83b31ef18d49	data_in	dataset	1.00
APOE	associated_with	gene	0.90
AMYLOID	associated_with	gene	0.90
MICROGLIA	associated_with	cell_type	0.82
TREM2	associated_with	gene	0.82
ALZHEIMER DISEASE	associated_with	gene	0.80
Stem Cell Therapy	modulates	drug	0.80
NEURODEGENERATION	protects_against	phenotype	0.70
TREM2	regulates	gene	0.66
NEURODEGENERATION	associated_with	gene	0.66
APP	associated_with	gene	0.66
ALS	associated_with	gene	0.65
APP	treats	gene	0.65
PHAGOCYTOSIS	causes	phenotype	0.65
PHAGOCYTOSIS	degrades	phenotype	0.65
BDNF	co_discussed	gene	0.65
AMYLOID-BETA	causes	protein	0.65
MICROGLIA	targets	cell_type	0.65
T CELLS	produces	cell_type	0.65
TYROBP	interacts_with	protein	0.64
AND	inhibits	gene	0.60
CR1	regulates	gene	0.60
GENES	expressed_in	gene	0.60
GENES	activates	gene	0.60
TAU	activates	gene	0.60
APP	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
TYROBP	associated_with	gene	0.60
ACE	associated_with	gene	0.60
CR1	causes	gene	0.60
MMP12	regulates	gene	0.60
ABCA7	regulates	gene	0.60
MICROGLIA	interacts_with	gene	0.60
STAT3	activates	gene	0.60
GAIN	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
APP/PSEN1	interacts_with	gene	0.60
TAUOPATHY	interacts_with	gene	0.60
TAU PATHOLOGY	regulates	gene	0.60
MS4A	associated_with	gene	0.60
APP	regulates	gene	0.60
SPI1	associated_with	gene	0.60
CYTOKINES	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CD33-Dependent Switch Hypothesis: CD33 Antagonism Redirects	0.519	synaptic-biology	Does SPP1-mediated synaptic engulfment r
CD33-Sialic Acid Pathway Modulation in Microglia	0.000	-	Cell type vulnerability in Alzheimer's D