gene

CD33

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD33: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

708Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

A gene referenced in 1 knowledge graph relationship. Key connections: inhibits phagocytosis (mechanism).

View on Wiki →

🧬 Gene Info

Gene Symbol	CD33
Full Name	Cluster of Differentiation 33
Aliases	Siglec-3
Chromosome	19q13.41
Function	Sialic acid binding: Recognizes α2,6-linked sialic acids on glycoproteins
Molecular Weight	67 kDa
Amino Acids	354 aa
Exons	7
Gene Type	Protein coding
Pathways	Apoptosis, Autophagy, Blood-Brain Barrier, Dysbiosis, Epigenetic
UniProt ID	P07846
NCBI Gene ID	945
Ensembl ID	ENSG00000141548
OMIM	159590
GeneCards	CD33
Human Protein Atlas	CD33
Associated Diseases	ALS, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, Aging
Known Drugs/Compounds	Stem Cell Therapy
Interactions	OVERVIEW, PSEN1, BCL2, APP, DAP12, APOE
KG Connections	708 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CD33["CD33"]
    CD33 -->|"interacts"| Als["Als"]
    CD33 -->|"interacts"| Tauopathy["Tauopathy"]
    CD33 -->|"inhibits"| Leukemia["Leukemia"]
    CD33 -->|"inhibits"| Ms["Ms"]
    CD33 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    CD33 -->|"target for"| Alzheimer["Alzheimer"]
    CD33 -->|"target for"| Neuroinflammation["Neuroinflammation"]
    CD33 -->|"target for"| Inflammation["Inflammation"]
    TYROBP["TYROBP"] -->|"interacts"| CD33
    APP["APP"] -->|"interacts"| CD33
    PSEN1["PSEN1"] -->|"interacts"| CD33
    BCL2["BCL2"] -->|"inhibits"| CD33
    MICROGLIA["MICROGLIA"] -->|"interacts"| CD33
    NEURODEGENERATION["NEURODEGENERATION"] -->|"target for"| CD33
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| CD33

Outgoing (516)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
microglia	modulates	cell_type	0.90
T cells	expressed_in	cell_type	0.90
Alzheimer Disease	risk_factor_for	disease	0.90
Microglial Phagocytosis of Amyloid-β	involved_in	process	0.85
Amyloid-Beta Clearance	regulates	process	0.85
Microglial Activation	regulates	process	0.85
Amyloid Pathology	involved_in	process	0.85
Microglial Function	modulates	process	0.85
Alzheimer's Disease	risk_factor_for	disease	0.85
Aβ pathology	inhibits	disease	0.80
microglial activation	regulates	process	0.80
neuroinflammation	activates	disease	0.80
Alzheimer's disease	biomarker_for	disease	0.80
macrophages	expressed_in	cell_type	0.80
oxidative stress response	participates_in	pathway	0.80
amyloid-beta clearance	modulates	process	0.75
Alzheimer	associated_with	disease	0.75
Als	therapeutic_target	disease	0.75
Als	activates	disease	0.75
Leukemia	therapeutic_target	disease	0.75
Alzheimer	regulates	disease	0.75
TREM2	implicated_in	gene	0.70
phagocytosis	activates	process	0.70
TREM2	suppresses	protein	0.70
neuroinflammation	associated_with	disease	0.70
GPNMB	causes	gene	0.70
CLU	regulates	gene	0.70
PSEN2	regulates	gene	0.70
MICROGLIA	associated_with	gene	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
ALZHEIMER	associated_with	gene	0.70
ALZHEIMER	regulates	gene	0.70
HLA	regulates	gene	0.70
Alzheimer's disease	interacts_with	disease	0.70
stem cells	expressed_in	cell_type	0.70
Alzheimer's disease	causes	disease	0.70
Parkinson's disease	causes	disease	0.70
CX3CR1	associated_with	gene	0.65
CYP46A1	associated_with	gene	0.65
TAU	associated_with	gene	0.65
TFEB	associated_with	gene	0.65
TNF	associated_with	gene	0.65
TREM2	causes	gene	0.65
neuroinflammation	co_discussed	concept	0.65
LRRK2	co_discussed	gene	0.65
TNF	co_discussed	gene	0.65
CLU	inhibits	gene	0.65
TREM2	increases_risk	gene	0.65
CLU	increases_risk	gene	0.65

Incoming (192)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	gene	1.00
ds-83b31ef18d49	data_in	dataset	1.00
APOE	associated_with	gene	0.90
AMYLOID	associated_with	gene	0.90
TREM2	associated_with	gene	0.82
MICROGLIA	associated_with	cell_type	0.82
Stem Cell Therapy	modulates	drug	0.80
NEURODEGENERATION	protects_against	phenotype	0.70
APP	associated_with	gene	0.66
TREM2	regulates	gene	0.66
NEURODEGENERATION	associated_with	gene	0.66
APP	treats	gene	0.65
BDNF	co_discussed	gene	0.65
ALS	associated_with	gene	0.65
PHAGOCYTOSIS	degrades	phenotype	0.65
PHAGOCYTOSIS	causes	phenotype	0.65
AMYLOID-BETA	causes	protein	0.65
T CELLS	produces	cell_type	0.65
MICROGLIA	targets	cell_type	0.65
TYROBP	interacts_with	protein	0.64
TYROBP	associated_with	gene	0.60
APP	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
APP	activates	gene	0.60
CD47	associated_with	gene	0.60
BCL2	inhibits	gene	0.60
DAP12	interacts_with	gene	0.60
P2RY12	inhibits	gene	0.60
CD44	inhibits	gene	0.60
TAU	activates	gene	0.60
GAIN	activates	gene	0.60
STAT3	activates	gene	0.60
MMP12	regulates	gene	0.60
IBA1	inhibits	gene	0.60
PSEN2	regulates	gene	0.60
TAU	regulates	gene	0.60
SORL1	regulates	gene	0.60
APOE4	regulates	gene	0.60
APP	regulates	gene	0.60
OVERVIEW	interacts_with	gene	0.60
ABCA1	associated_with	entity	0.60
ABI3	associated_with	entity	0.60
ADAM17	associated_with	entity	0.60
CD2AP	associated_with	entity	0.60
PLD3	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
CR1	associated_with	gene	0.60
CASS4	associated_with	gene	0.60
HuM195	binds_to	protein	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.567

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.670

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.487

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CD33

Understanding Entity Pages

Summary

Wiki Pages (21)

CD33 — Cluster of Differentiation 33

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Novel Therapy Index

Alzheimer's Disease Mechanism Index

Therapeutics

neuroinflammation

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

Epigenetic Alterations in Alzheimer's Disease

Novartis Alzheimer's Disease Phase 2 Trial (NCT07094516)

Microglial Senescence Pathway in Neurodegeneration

Nanomedicine Approaches to Alzheimer's Disease

Neuroinflammation Across AD, PD, ALS, FTD, and HD

CR1 Gene — Complement Component 1q Receptor

MS4A4A Gene — Membrane-Spanning 4-Domains A4A

Microglial Phagocytosis in Neurodegeneration

Mechanisms Dashboard

Neuroinflammation in Alzheimer's Disease

Microglia Activation Mechanism

IL1RAP — Interleukin-1 receptor accessory protein

FTD-ALS Spectrum