Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Immunity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Dementia Risk | contributes_to | phenotype | 0.80 |
| Neurodegenerative Diseases | contributes_to | disease | 0.80 |
| MAPK | activates | pathway | 0.80 |
| Major Depressive Disorder | associated_with | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 30820047 | implicated in | paper | 0.90 |
| Autophagy | involved_in | process | 0.85 |
| Dysfunctional Mitochondria Elimination | modulates | process | 0.85 |
| Non-canonical Autophagy | involved_in | pathway | 0.80 |
| LOXL3 | regulates | gene | 0.80 |
| NF-κB | participates_in | pathway | 0.80 |
| Ferroptosis | associated_with | process | 0.80 |
| MDM2 | regulates | protein | 0.75 |
| IL17 | regulates | pathway | 0.70 |
| LC3-associated phagocytosis | associated_with | process | 0.70 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.444
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning Immunity in their description or question text
Score: 0.380 · developmental-neurobiology · 2026-04-27
The astrocytic metabolic trained immunity hypothesis proposes that perinatal immune activation fundamentally reprograms
Score: 0.351 · developmental-neurobiology · 2026-04-26
The astrocytic metabolic trained immunity hypothesis proposes that perinatal immune activation fundamentally reprograms
Score: 0.000 · unknown disease · 2026-04-28
Persistent epigenetic scars from past inflammatory episodes create trained immunity states that exacerbate neurodegenera
Score: 0.000 · unknown disease · 2026-04-28
Pathological protein aggregates induce a form of trained immunity in microglia through metabolic reprogramming that pers