Innate Immunity Memory Erasure Protocol
🧪 Overview
Persistent epigenetic scars from past inflammatory episodes create trained immunity states that exacerbate neurodegeneration. Sequential therapy combining autophagy enhancers with selective histone demethylase inhibitors.
Debate provenance: derived from debate `sess_SDA-2026-04-04-gap-epigenetic-reprog-b685190e` on question: Epigenetic reprogramming in aging neurons. Consensus signal: domain_expert, skeptic, synthesizer, theorist discussed the mechanism terms Erasure, Immunity, Innate, KDM1A, Memory, Protocol, autophagy, epigenetic. Novelty signal: skeptic-discussed-with-qualified-concession.
🧬 Mechanism
Auto-built from this analysis's top knowledge-graph edges.
graph TD
AMPK_SIRT1_PGC1__axis["AMPK-SIRT1-PGC1α axis"] -->|associated with| neurodegeneration["neurodegeneration"]
SMARCA4["SMARCA4"] -->|regulates| SWI_SNF_complexes["SWI/SNF complexes"]
SMARCA4_1["SMARCA4"] -->|activates| nucleosome_remodeling["nucleosome remodeling"]
ATPase_activity["ATPase activity"] -->|causes| chromatin_remodeling["chromatin remodeling"]
nutrient_sensing["nutrient sensing"] -->|dysregulated in| aging["aging"]
APOE["APOE"] -->|regulates| cholesterol_metabolism["cholesterol_metabolism"]
PGC1_["PGC1α"] -->|activates| mitochondrial_biogenesis_["mitochondrial biogenesis pathway"]
NAD__NADH_ratio["NAD+/NADH ratio"] -->|modulates| SIRT1_activity["SIRT1 activity"]
PGC1__2["PGC1α"] -->|activates| NRF1_2["NRF1/2"]
PGC1__3["PGC1α"] -->|activates| TFAM["TFAM"]
AMPK["AMPK"] -->|regulates| Cellular_energy_sensing["Cellular energy sensing"]
AMPK_4["AMPK"] -->|activates| Downstream_effectors["Downstream effectors"]
style AMPK_SIRT1_PGC1__axis fill:#81c784,stroke:#333,color:#000
style neurodegeneration fill:#ef5350,stroke:#333,color:#000
style SMARCA4 fill:#4fc3f7,stroke:#333,color:#000
style SWI_SNF_complexes fill:#4fc3f7,stroke:#333,color:#000
style SMARCA4_1 fill:#4fc3f7,stroke:#333,color:#000
style nucleosome_remodeling fill:#4fc3f7,stroke:#333,color:#000
style ATPase_activity fill:#4fc3f7,stroke:#333,color:#000
style chromatin_remodeling fill:#4fc3f7,stroke:#333,color:#000
style nutrient_sensing fill:#4fc3f7,stroke:#333,color:#000
style aging fill:#4fc3f7,stroke:#333,color:#000
style APOE fill:#ce93d8,stroke:#333,color:#000
style cholesterol_metabolism fill:#81c784,stroke:#333,color:#000
style PGC1_ fill:#4fc3f7,stroke:#333,color:#000
style mitochondrial_biogenesis_ fill:#81c784,stroke:#333,color:#000
style NAD__NADH_ratio fill:#4fc3f7,stroke:#333,color:#000
style SIRT1_activity fill:#4fc3f7,stroke:#333,color:#000
style PGC1__2 fill:#4fc3f7,stroke:#333,color:#000
style NRF1_2 fill:#4fc3f7,stroke:#333,color:#000
style PGC1__3 fill:#4fc3f7,stroke:#333,color:#000
style TFAM fill:#4fc3f7,stroke:#333,color:#000
style AMPK fill:#4fc3f7,stroke:#333,color:#000
style Cellular_energy_sensing fill:#4fc3f7,stroke:#333,color:#000
style AMPK_4 fill:#4fc3f7,stroke:#333,color:#000
style Downstream_effectors fill:#4fc3f7,stroke:#333,color:#000⚖️ Evidence
No linked papers recorded for this hypothesis yet.
🏥 Translation
🧬 3D Protein Structure — KDM1A
No curated PDB or AlphaFold mapping for KDM1A yet. Search RCSB →
💉 Clinical Trials
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for KDM1A.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
🏆 Tournament
🏆 Arenas / Elo
📊 Market Indicators
💾 Resource Usage
▸Metadatasource: v1_phase_c_backfill · origin_type: debate_round_mining
| source | v1_phase_c_backfill |
| origin_type | debate_round_mining |
| _schema_version | 1 |