Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ISCHEMIA-REPERFUSION INJURY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ISCHEMIA-REPERFUSION INJURY |
Knowledge base pages for this entity
graph TD
ISCHEMIA_REPERFUSION_INJURY["ISCHEMIA-REPERFUSION INJURY"]
ISCHEMIA_REPERFUSION_INJURY -->|"causes"| Acute_Kidney_Injury["Acute Kidney Injury"]
ISCHEMIA_REPERFUSION_INJURY -->|"causes"| Tissue_Damage["Tissue Damage"]
ISCHEMIA_REPERFUSION_INJURY -->|"contributes to"| Hemorrhagic_Transformation["Hemorrhagic Transformation"]
ISCHEMIA_REPERFUSION_INJURY -->|"activates"| lactate["lactate"]
GPR31["GPR31"] -->|"involved_in"| ISCHEMIA_REPERFUSION_INJURY
AEP["AEP"] -->|"involved_in"| ISCHEMIA_REPERFUSION_INJURY
Asparagine_Endopeptidase["Asparagine Endopeptidase"] -->|"involved_in"| ISCHEMIA_REPERFUSION_INJURY
ASPARAGINE_ENDOPEPTIDASE["ASPARAGINE ENDOPEPTIDASE"] -->|"contributes to"| ISCHEMIA_REPERFUSION_INJURY
Wnt_signaling_pathway["Wnt signaling pathway"] -->|"regulates"| ISCHEMIA_REPERFUSION_INJURY
lactylation["lactylation"] -->|"regulates"| ISCHEMIA_REPERFUSION_INJURY| Target | Relation | Type | Str |
|---|---|---|---|
| Acute Kidney Injury | causes | disease | 0.95 |
| Tissue Damage | causes | phenotype | 0.90 |
| Hemorrhagic Transformation | contributes_to | phenotype | 0.80 |
| reactive oxygen species | increases | compound | 0.80 |
| AEP | activates | protein | 0.80 |
| lactate | activates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GPR31 | involved_in | receptor | 0.90 |
| Asparagine Endopeptidase | involved_in | enzyme | 0.85 |
| ASPARAGINE ENDOPEPTIDASE | contributes_to | enzyme | 0.85 |
| OGD/R | associated_with | process | 0.85 |
| Chemerin-Cmklr1 | involved_in | mechanism | 0.85 |
| Ferroptosis | associated_with | process | 0.85 |
| Asparagine Endopeptidase | mediates | enzyme | 0.80 |
| ASPARAGINE ENDOPEPTIDASE | involved_in | enzyme | 0.80 |
| Excessive Inflammation | associated_with | phenotype | 0.80 |
| GPX4 | associated_with | protein | 0.75 |
| Wnt signaling pathway | regulates | pathway | 0.70 |
| lactylation | regulates | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||