Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | KCNN2 |
| Full Name | Potassium Calcium-Activated Channel Subfamily N Member 2 |
| Aliases | SK2, KCa2.2, hSK2 |
| Chromosome | 5q22.1 |
| Protein Type | Channel |
| Function | encodes a neuronal small-conductance calcium-activated potassium channel with critical roles in synaptic plasticity, learning, and memory. |
| Subcellular Localization | dendritic compartments where they shape synaptic integration and plasticity. [@bond2004] |
| UniProt ID | Q9H5Y2 |
| NCBI Gene ID | 3777 |
| Ensembl ID | ENSG00000162610 |
| OMIM | 609922 |
| GeneCards | KCNN2 |
| Human Protein Atlas | KCNN2 |
| Associated Diseases | neurodegeneration |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KCNN2["<b>KCNN2</b>"]
Schizophrenia{"Schizophrenia"}
KCNN2 -->|"therapeutic target"| Schizophrenia
Als{"Als"}
KCNN2 -->|"therapeutic target"| Als
Autism{"Autism"}
KCNN2 -->|"therapeutic target"| Autism
Depression{"Depression"}
KCNN2 -->|"therapeutic target"| Depression
Ms{"Ms"}
KCNN2 -->|"therapeutic target"| Ms
GRIA3["GRIA3"]
KCNN2 -->|"associated with"| GRIA3
KCNK2["KCNK2"]
KCNN2 -->|"therapeutic target"| KCNK2
neurodegeneration["neurodegeneration"]
KCNN2 -->|"implicated in"| neurodegeneration
KCNMB1["KCNMB1"]
KCNMB1 -->|"therapeutic target"| KCNN2
style KCNN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Schizophrenia | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Autism | therapeutic_target | disease | 0.65 |
| Depression | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| GRIA3 | associated_with | gene | 0.60 |
| KCNK2 | therapeutic_target | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| KCNMB1 | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||