disease

Autism

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Autism: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

939Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Autism is a disease characterized by neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with Aging, Als, Alzheimer. Connected to 316 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	TGM2, CNTNAP4, FOXP1, DNA, MTOR, GENES, CAPRIN1, PTEN
Therapeutic Agents	MTOR Inhibitors
KG Connections	570 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Cerebellar Golgi Cells in Autism Spectrum Disorder

cell · 1040 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    Autism["Autism"] -->|"regulates"| Synaptic_Plasticity["Synaptic Plasticity"]
    Autism["Autism"] -->|"associated"| Synaptic_Plasticity_1["Synaptic Plasticity"]
    Autism["Autism"] -->|"regulates"| Complement["Complement"]
    Autism["Autism"] -.->|"inhibits"| Mtor["Mtor"]
    Autism["Autism"] -->|"activates"| Autophagy["Autophagy"]
    Autism["Autism"] -->|"activates"| Synaptic_Plasticity_2["Synaptic Plasticity"]
    JUN["JUN"] -->|"regulates"| Autism["Autism"]
    DAB1["DAB1"] -->|"regulates"| Autism["Autism"]
    FYN["FYN"] -->|"regulates"| Autism["Autism"]
    SRC["SRC"] -->|"regulates"| Autism["Autism"]
    style Autism fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (381)

Target	Relation	Type	Str
Inflammation	associated_with	disease	0.95
Als	interacts_with	disease	0.75
Neuroinflammation	associated_with	disease	0.75
Schizophrenia	associated_with	disease	0.75
Autophagy	activates	pathway	0.70
Mtor	associated_with	pathway	0.70
Synaptic Plasticity	implicated_in	pathway	0.70
Mtor	interacts_with	pathway	0.70
Als	associated_with	disease	0.65
Als	implicated_in	disease	0.65
Depression	associated_with	disease	0.65
Als	activates	disease	0.65
Synaptic Plasticity	regulates	pathway	0.60
Synaptic Plasticity	associated_with	pathway	0.60
Complement	regulates	pathway	0.60
Mtor	inhibits	pathway	0.60
Synaptic Plasticity	activates	pathway	0.60
Neurogenesis	activates	pathway	0.60
Complement	activates	pathway	0.60
Circadian Rhythm	contributes_to	pathway	0.60
Dna Methylation	associated_with	pathway	0.60
Epigenetic	regulates	pathway	0.60
Autophagy	associated_with	pathway	0.60
Oxidative Stress	inhibits	pathway	0.60
Synaptic Plasticity	inhibits	pathway	0.60
Epigenetic	activates	pathway	0.60
Wnt	inhibits	pathway	0.60
Epigenetic	therapeutic_target	pathway	0.60
Akt	inhibits	pathway	0.60
Pi3K	inhibits	pathway	0.60
Notch	associated_with	pathway	0.60
Ferroptosis	associated_with	pathway	0.60
Circadian Rhythm	therapeutic_target	pathway	0.60
Pi3K	contributes_to	pathway	0.60
Akt	contributes_to	pathway	0.60
Akt	therapeutic_target	pathway	0.60
Pi3K	therapeutic_target	pathway	0.60
Notch	activates	pathway	0.60
Differentiation	activates	pathway	0.60
Stem Cell	activates	pathway	0.60
Immune Response	implicated_in	pathway	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Autophagy	interacts_with	pathway	0.60
Oxidative Stress	activates	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Differentiation	interacts_with	pathway	0.60
Ms	associated_with	disease	0.55
Aging	associated_with	disease	0.55
Ischemia	associated_with	disease	0.55
Tumor	associated_with	disease	0.55

Incoming (558)

Source	Relation	Type	Str
INFLAMMATION	associated_with	gene	0.85
MICROGLIA	activates	gene	0.85
NEUROINFLAMMATION	associated_with	gene	0.85
MICROGLIA	implicated_in	gene	0.85
RLN	associated_with	protein	0.85
Microbiota	associated_with	process	0.80
MTOR Inhibitors	treats	drug	0.80
Serotonin	associated_with	compound	0.80
GENES	interacts_with	gene	0.75
MTOR	associated_with	gene	0.75
OXIDATIVE STRESS	therapeutic_target	gene	0.75
OXIDATIVE STRESS	activates	gene	0.75
CYTOKINES	activates	gene	0.75
DEPRESSION	associated_with	gene	0.75
ANXIETY	associated_with	gene	0.75
AUTOPHAGY	activates	gene	0.75
MITOCHONDRIA	associated_with	gene	0.75
OXIDATIVE STRESS	associated_with	gene	0.75
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.75
TSC2	interacts_with	gene	0.75
TSC1	interacts_with	gene	0.75
MTOR	interacts_with	gene	0.75
Microglia	associated_with	cell_type	0.75
JUN	regulates	gene	0.65
DAB1	regulates	gene	0.65
FYN	regulates	gene	0.65
SRC	regulates	gene	0.65
TGM2	associated_with	gene	0.65
CX3CR1	regulates	gene	0.65
C1Q	regulates	gene	0.65
CD47	regulates	gene	0.65
OVERVIEW	regulates	gene	0.65
JUN	interacts_with	gene	0.65
MTOR	inhibits	gene	0.65
C1Q	activates	gene	0.65
CNTNAP4	associated_with	gene	0.65
MMP9	inhibits	gene	0.65
CNTNAP2	inhibits	gene	0.65
KCNMB1	therapeutic_target	gene	0.65
KCNN2	therapeutic_target	gene	0.65
GRIA3	therapeutic_target	gene	0.65
KCNK2	therapeutic_target	gene	0.65
FOXP1	associated_with	gene	0.65
DISC1	regulates	gene	0.65
DNA	associated_with	gene	0.65
GENES	associated_with	gene	0.65
CALCOCO2	expressed_in	gene	0.65
FMN2	expressed_in	gene	0.65
IL16	expressed_in	gene	0.65
GABARAPL1	biomarker_for	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

neurodevelopment | 2026-04-15 | 1 hypotheses Top: 0.576

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Autism

Understanding Entity Pages

Summary

Wiki Pages (21)

Cerebellar Golgi Cells in Autism Spectrum Disorder

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

GRIA3 Gene

Microglial Cells — Cell Type Hierarchy

CNTN5 — Contactin 5

Autophagy Mechanisms

ncam2

CNTN6 — Contactin 6

CNTN4 — Contactin 4

Sulforaphane and Nrf2 Activation for Neuroprotection

nf1-protein

CNTN3 — Contactin 3

ZDHHC13 — Zinc Finger DHHC-Type Containing 13

MACF1 — Microtubule-actin crosslinking factor 1

Angelman Syndrome

NPAS3 Gene

Synaptic Dysfunction in Neurodegeneration

Kv7.3 Potassium Channel

DDX3X Gene

Peroxisomal Dysfunction