Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GRIA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GRIA3 encodes the GluA3 AMPA receptor subunit, critical for fast excitatory synaptic transmission and implicated in Alzheimer's disease, ALS, and X-linked intellectual disability
| Gene Symbol | GRIA3 |
| Chromosome | Xq21.3 |
| Protein Family | AMPA receptor family, ionotropic glutamate receptor family |
| Function | AMPA receptors containing GluA3 subunits mediate fast excitatory neurotransmission at the vast majority of synapses in the brain. |
| Subcellular Localization | Postsynaptic membrane, synapse |
| Molecular Weight | 100 kDa |
| Amino Acids | 894 aa |
| Exons | 22 |
| Pathways | Camp Signaling |
| UniProt ID | [P42263](https://www.uniprot.org/uniprot/P42263) |
| GeneCards | GRIA3 |
| Human Protein Atlas | GRIA3 |
| Genomic Span | ~50 kb |
| Number of Exons | 22 |
| Transcript Length | ~4.5 kb (coding sequence) |
| Associated Diseases | Neurodegeneration |
| KG Connections | 37 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GRIA3["<b>GRIA3</b>"]
Schizophrenia{"Schizophrenia"}
GRIA3 -->|"therapeutic target"| Schizophrenia
Als{"Als"}
GRIA3 -->|"therapeutic target"| Als
Autism{"Autism"}
GRIA3 -->|"therapeutic target"| Autism
Depression{"Depression"}
GRIA3 -->|"therapeutic target"| Depression
Ms{"Ms"}
GRIA3 -->|"therapeutic target"| Ms
KCNK2["KCNK2"]
GRIA3 -->|"therapeutic target"| KCNK2
neurodegeneration["neurodegeneration"]
GRIA3 -->|"implicated in"| neurodegeneration
KCNMB1["KCNMB1"]
KCNMB1 -->|"therapeutic target"| GRIA3
KCNN2["KCNN2"]
KCNN2 -->|"associated with"| GRIA3
KCNK2 -->|"therapeutic target"| GRIA3
style GRIA3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Schizophrenia | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Autism | therapeutic_target | disease | 0.65 |
| Depression | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Dementia | regulates | disease | 0.65 |
| Aging | regulates | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| KCNK2 | therapeutic_target | gene | 0.60 |
| PDE4D | regulates | gene | 0.60 |
| MAPT | regulates | gene | 0.60 |
| EGFR | regulates | gene | 0.60 |
| CLU | regulates | gene | 0.60 |
| Rb | regulates | protein | 0.60 |
| AGING | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| Camp Signaling | regulates | pathway | 0.60 |
| Egfr | regulates | protein | 0.60 |
| App | associated_with | protein | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| KCNMB1 | therapeutic_target | gene | 0.60 |
| KCNN2 | associated_with | gene | 0.60 |
| KCNK2 | therapeutic_target | gene | 0.60 |
| ACTN2 | regulates | gene | 0.60 |
| CLU | regulates | gene | 0.60 |
| PDE4D | regulates | gene | 0.60 |
| EGFR | regulates | gene | 0.60 |
| AGING | regulates | gene | 0.60 |
| NEURODEGENERATION | associated_with | gene | 0.60 |
| FHL1 | regulates | gene | 0.50 |
| MAPT | regulates | gene | 0.50 |
| ALZHEIMER | regulates | gene | 0.50 |
| DEMENTIA | regulates | gene | 0.50 |
| GENES | co_discussed | gene | 0.50 |
| actn2 | regulates | gene | 0.50 |
| Neurodegeneration | associated_with | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||