Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KIF5C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | KIF5C |
| Aliases | Neuronal |
| Chromosome | 2q23.3 |
| Function | KIF5C is a neuron-specific kinesin heavy chain that functions in axonal transport. |
| Primary Expression | brain, particularly in cortical neurons |
| Molecular Weight | 109 kDa |
| Pathways | Cargo Transport |
| UniProt ID | Q9P0N2 |
| NCBI Gene ID | 3800 |
| Ensembl ID | ENSG00000154640 |
| GeneCards | KIF5C |
| Human Protein Atlas | KIF5C |
| Hereditary Spastic Paraplegia (HSP) | Mutations in KIF1A, KIF5A cause HSP |
| Charcot-Marie-Tooth Disease | KIF1B (CMT2A), KIF1A, KIF5A |
| Alzheimer's Disease | Impaired transport contributes to amyloid and tau pathology |
| Associated Diseases | Intellectual Disability, Cortical Malformations |
| Interactions | KIF5A, AND, Raf, TRAK2, KINESIN-1, HNRNPA2B1 |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KIF5C["<b>KIF5C</b>"]
PRV["PRV"]
KIF5C -->|"interacts with"| PRV
KIF5A["KIF5A"]
KIF5C -->|"interacts with"| KIF5A
TRAK1["TRAK1"]
KIF5C -->|"associated with"| TRAK1
AND["AND"]
KIF5C -->|"interacts with"| AND
neurodegeneration["neurodegeneration"]
KIF5C -->|"implicated in"| neurodegeneration
KIF5A -->|"interacts with"| KIF5C
TRAK1 -->|"associated with"| KIF5C
style KIF5C fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| TRAK2 | interacts_with | protein | 0.95 |
| Cargo Transport | involved_in | process | 0.90 |
| PRV | interacts_with | entity | 0.80 |
| KIF5A | interacts_with | gene | 0.60 |
| Kinesin | associated_with | protein | 0.60 |
| TRAK1 | associated_with | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| Raf | interacts_with | protein | 0.60 |
| prion disease | interacts_with | disease | 0.55 |
| KINESIN-1 | interacts_with | protein | 0.50 |
| TRAK1 | interacts_with | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||