protein

Raf

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Raf: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1295Connections

6Hypotheses

4Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	Raf
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Cancer, Dementia
Interactions	MITOCHONDRIA, ARF6, REELIN, DYNEIN, DAPK1, APP
KG Connections	1104 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Raf["Raf"] -->|"expressed in"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Raf["Raf"] -->|"expressed in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    style Amyotrophic_Lateral_Sclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Raf["Raf"] -->|"expressed in"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Raf["Raf"] -->|"regulates"| Ischemia["Ischemia"]
    style Ischemia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Raf["Raf"] -->|"biomarker for"| Neurodegeneration["Neurodegeneration"]
    style Neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Raf["Raf"] -->|"biomarker for"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Raf["Raf"] -->|"biomarker for"| Neuroinflammation["Neuroinflammation"]
    style Neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    TARDBP["TARDBP"] -->|"regulates"| Raf["Raf"]
    style TARDBP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    FTLD["FTLD"] -->|"expressed in"| Raf["Raf"]
    style FTLD fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    RNA["RNA"] -->|"regulates"| Raf["Raf"]
    style RNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ALS["ALS"] -->|"expressed in"| Raf["Raf"]
    style ALS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    APOE4["APOE4"] -->|"expressed in"| Raf["Raf"]
    style APOE4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Raf fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (317)

Target	Relation	Type	Str
Als	expressed_in	disease	0.60
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.60
Alzheimer	expressed_in	disease	0.60
Ischemia	regulates	disease	0.60
Neurodegeneration	biomarker_for	disease	0.60
Cancer	biomarker_for	disease	0.60
Neuroinflammation	biomarker_for	disease	0.60
Alzheimer	interacts_with	disease	0.60
Multiple Sclerosis	therapeutic_target	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Als	activates	disease	0.60
Als	transports	disease	0.60
Als	associated_with	disease	0.60
Aging	associated_with	disease	0.60
Aging	expressed_in	disease	0.60
Parkinson	expressed_in	disease	0.60
Huntington	expressed_in	disease	0.60
Cancer	regulates	disease	0.60
Tauopathy	activates	disease	0.60
Pyroptosis	therapeutic_target	disease	0.60
Fibrosis	therapeutic_target	disease	0.60
Ferroptosis	therapeutic_target	disease	0.60
Ferroptosis	regulates	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Spinal Muscular Atrophy	associated_with	disease	0.60
Dementia	associated_with	disease	0.60
Frontotemporal Dementia	associated_with	disease	0.60
Multiple Sclerosis	transports	disease	0.60
Depression	activates	disease	0.60
Diabetes	associated_with	disease	0.60
Ferroptosis	activates	disease	0.60
Necroptosis	activates	disease	0.60
Aging	interacts_with	disease	0.60
Als	inhibits	disease	0.60
Autism	interacts_with	disease	0.60
Schizophrenia	interacts_with	disease	0.60
Cancer	expressed_in	disease	0.60
Parkinson	inhibits	disease	0.60
Neurodegeneration	inhibits	disease	0.60
Frontotemporal Dementia	regulates	disease	0.60
Dementia	regulates	disease	0.60
Amyotrophic Lateral Sclerosis	regulates	disease	0.60
Neurodegeneration	activates	disease	0.60
Amyotrophic Lateral Sclerosis	causes	disease	0.60
Dementia	causes	disease	0.60
Frontotemporal Dementia	causes	disease	0.60
Fibrosis	inhibits	disease	0.60
Ferroptosis	inhibits	disease	0.60
Senescence	therapeutic_target	disease	0.60
Addiction	therapeutic_target	disease	0.60

Incoming (978)

Source	Relation	Type	Str
TARDBP	regulates	gene	0.60
FTLD	expressed_in	gene	0.60
RNA	regulates	gene	0.60
ALS	expressed_in	gene	0.60
APOE4	expressed_in	gene	0.60
DNA	regulates	gene	0.60
TDP-43	regulates	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
MTOR	regulates	gene	0.60
NADH	regulates	gene	0.60
CTSD	regulates	gene	0.60
MTORC1	regulates	gene	0.60
PIK3C3	regulates	gene	0.60
CAT	regulates	gene	0.60
PPARG	regulates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
MAP1LC3B	regulates	gene	0.60
SREBF1	regulates	gene	0.60
RPS6KB1	regulates	gene	0.60
RUBCN	regulates	gene	0.60
ACTB	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
PPARA	regulates	gene	0.60
EGFR	regulates	gene	0.60
RPS6	regulates	gene	0.60
ATG	regulates	gene	0.60
LAMP1	regulates	gene	0.60
RAB7A	regulates	gene	0.60
LRP2	regulates	gene	0.60
ATP	regulates	gene	0.60
PPARGC1A	regulates	gene	0.60
CPT1A	regulates	gene	0.60
EIF4EBP1	regulates	gene	0.60
ARF6	interacts_with	gene	0.60
REELIN	interacts_with	gene	0.60
BRAF	associated_with	gene	0.60
OVERVIEW	biomarker_for	gene	0.60
H3F3A	associated_with	gene	0.60
CIC	associated_with	gene	0.60
ATRX	associated_with	gene	0.60
FUBP1	associated_with	gene	0.60
JUN	biomarker_for	gene	0.60
TERT	associated_with	gene	0.60
GAIN	biomarker_for	gene	0.60
P2RY12	biomarker_for	gene	0.60
TREM2	biomarker_for	gene	0.60
TMEM119	biomarker_for	gene	0.60
MICROGLIA	biomarker_for	gene	0.60
FCRLS	biomarker_for	gene	0.60
DYNEIN	interacts_with	gene	0.60

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Lysosomal Enzyme Trafficking Correction	0.489	neurodegeneration	Autophagy-lysosome pathway convergence a
TFAM overexpression creates mitochondrial donor-recipient gr	0.474	neurodegeneration	Mitochondrial transfer between astrocyte
Sphingomyelin Synthase Activators for Raft Remodeling	0.468	neurodegeneration	Lipid raft composition changes in synapt
APOE-Mediated Synaptic Lipid Raft Stabilization	0.426	neurodegeneration	Mechanistic role of APOE in neurodegener
Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy	0.426	neurodegeneration	Mitochondrial transfer between neurons a

Palmitoylation-Targeted BACE1 Trafficking Disruptors	0.407	neurodegeneration	Lipid raft composition changes in synapt

Mentioning Analyses (4)

Scientific analyses that reference this entity

What are the specific molecular mechanisms by which peripheral monocytes cross t

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.584

What are the molecular determinants that control directional mitochondrial trans

cellular neuroscience | 2026-04-12 | 0 hypotheses

Systemic immune profiling and peripheral immune contributions to neurodegenerati

neurodegeneration | 2026-04-04 | 0 hypotheses

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.648

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Designed endocytosis-inducing proteins degrade targets and amplify signals. [PMID:39322662]	Huang B, Abedi M, Ahn G, Coventry B, Sap	Nature	2025	1
Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy t [PMID:37651673]	Deng Z, He M, Hu H, Zhang W, Zhang Y, Ge	Autophagy	2024	1
TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic [PMID:38783142]	Liu H, Zhen C, Xie J, Luo Z, Zeng L, Zha	Nat Cell Biol	2024	1
Collapse of late endosomal pH elicits a rapid Rab7 response via the V-ATPase and [PMID:38578235]	Mulligan RJ, Magaj MM, Digilio L, Redema	J Cell Sci	2024	1
IGF2 in memory, neurodevelopmental disorders, and neurodegenerative diseases. [PMID:37031050]	Alberini CM	Trends Neurosci	2023	1
Mitochondrial-derived damage-associated molecular patterns amplify neuroinflamma [PMID:35233090]	Lin MM, Liu N, Qin ZH, Wang Y	Acta Pharmacol Sin	2022	1
Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217]	Chang CH, Lin CH, Lane HY	Int J Mol Sci	2021	1
Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic [PMID:33408785]	Zhao M, Wang Y, Li L, Liu S, Wang C, Yua	Theranostics	2021	1
Mitochondrial DNA copy number in human disease: the more the better? [PMID:33314045]	Filograna R, Mennuni M, Alsina D, Larsso	FEBS Lett	2021	1
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death. [PMID:32186434]	Li C, Zhang Y, Liu J, Kang R, Klionsky D	Autophagy	2021	1
Interactions of IGF-II with the IGF2R/cation-independent mannose-6-phosphate rec [PMID:19251056]	Brown J, Jones EY, Forbes BE	Vitam Horm	2009	1
Blocking palmitoyl-transferase activity reduces BACE1 membrane localization and [PMID:23395894]	Unknown	Molecular Neurodegeneration		0
Amyloid-β fibrils accumulated in preeclamptic placentas suppress cytotrophoblast [PMID:41558820]	Nishioka K, Ikezaki M, Iwahashi N, Araka	Life Sci Alliance	2026	0
An anti-inflammatory neuroenhancer mitigates amyloid-β pathology to improve Alzh [PMID:41696149]	Fang W, Zhao J, Li L, Wang Y, Xu ZP et a	Mater Today Bio	2026	0
Anti-ASC antibodies alleviate Alzheimer's disease-type pathology in APP/PS1 mice [PMID:41707905]	He L, Xiaopeng Z, Juan D, Yan L	Neuroscience	2026	0
Intranasal administration of neural stem cell-derived extracellular vesicles pre [PMID:41923110]	Natale F, Dellaria A, Nifo Sarrapochiell	Alzheimer's research & therapy	2026	0
Salvianolic acid a inhibits neuroinflammation and ameliorates Alzheimer's diseas [PMID:41930874]	Xiao S, Han Y, Yan J, Wu L, Lin H et al.	Int Immunopharmacol	2026	0
Repurposing FDA-approved drugs as multi-target neuroprotective agents for Alzhei [PMID:41946775]	Phemphunananchai K, Waiwut P, Phetcharab	Scientific reports	2026	0
Nano-magnolol enhances the modulatory effects of magnolol on cognitive performan [PMID:41954680]	Youssef B, Ibrahim EA, Moselhy SS, ElShe	Discov Nano	2026	0
BACE-1 inhibitors as potential drug candidates for treatment of Alzheimer's dise [PMID:41966670]	Kaur N, Gupta S, Bansal G, Bansal Y	Mol Divers	2026	0

Raf

Understanding Entity Pages

Wiki Pages (20)

NTF4 Protein

TREM2 Mechanism Hub

Neurotrophin Signaling Pathways in Neurodegeneration

VEGF/Angiogenesis Pathway in Neurodegeneration

nf1-protein

IGF-1 Signaling Pathway in Neurodegeneration

CNTF Signaling Pathway in Neurodegeneration

RASGRP1 Gene

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

Type 3 Diabetes Hypothesis of Alzheimer's Disease

CNTFR Gene

EPHA7 Gene

EPHA6 — Ephrin Type-A Receptor 6

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

BDNF/Neurotrophin Signaling in Neurodegeneration

MAPK9 Gene

vip-vasoactive-intestinal-peptide-signaling-neurodegeneration

FGF Signaling Pathway in Neurodegeneration

MAPK/ERK Signaling Pathway in Neurodegeneration

EPHA8 Gene