gene

KIF5B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KIF5B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

118Connections

0Hypotheses

0Analyses

50Outgoing

48Incoming

Summary

KIF5B is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, regulates. Associated with Als, Amyotrophic Lateral Sclerosis, Glaucoma. Connected to 39 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	KIF5B
Function	The KIF5B gene encodes Kinesin-1 Heavy Chain Protein, a protein involved in various cellular processes relevant to neuronal function and survival.
Primary Expression	various brain regions, with notable expression in: - Cerebral cortex - Hippocampus - Basal gang
Pathways	IGF-1
Ensembl ID	ENSG00000153257
GeneCards	KIF5B
Human Protein Atlas	KIF5B
Associated Diseases	ALS, neurodegeneration
Interactions	OPTN, MYC, OPTINEURIN, PVALB, SST, AURKB
KG Connections	118 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (19)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    KIF5B["<b>KIF5B</b>"]
    IGF_1(["IGF-1"])
    KIF5B -->|"regulates"| IGF_1
    Ischemia{"Ischemia"}
    KIF5B -->|"activates"| Ischemia
    Ms{"Ms"}
    KIF5B -->|"activates"| Ms
    Stroke{"Stroke"}
    KIF5B -->|"activates"| Stroke
    ASTROCYTES["ASTROCYTES"]
    KIF5B -->|"activates"| ASTROCYTES
    CD38["CD38"]
    KIF5B -->|"regulates"| CD38
    APOPTOSIS["APOPTOSIS"]
    KIF5B -->|"activates"| APOPTOSIS
    TRAK1["TRAK1"]
    KIF5B -->|"regulates"| TRAK1
    MIRO1["MIRO1"]
    KIF5B -->|"regulates"| MIRO1
    Apoptosis(["Apoptosis"])
    KIF5B -->|"activates"| Apoptosis
    neurodegeneration["neurodegeneration"]
    KIF5B -->|"implicated in"| neurodegeneration
    style KIF5B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (70)

Target	Relation	Type	Str
IGF-1	regulates	pathway	0.80
Ischemia	activates	disease	0.65
Ms	activates	disease	0.65
Stroke	activates	disease	0.65
Tumor	interacts_with	disease	0.65
Melanoma	interacts_with	disease	0.65
Hypertension	activates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Glaucoma	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
CD38	regulates	gene	0.60
MIRO1	regulates	gene	0.60
OPTN	interacts_with	gene	0.60
MYC	interacts_with	gene	0.60
OPTN	activates	gene	0.60
OPTINEURIN	activates	gene	0.60
CDC42	associated_with	gene	0.60
PVALB	interacts_with	gene	0.60
SST	interacts_with	gene	0.60
GAP43	associated_with	gene	0.60
AURKB	interacts_with	gene	0.60
NEFH	associated_with	gene	0.60
RANK	interacts_with	gene	0.60
NEFL	associated_with	gene	0.60
KIF15	associated_with	gene	0.60
CALM1	interacts_with	gene	0.60
RANK	therapeutic_target	gene	0.60
neurodegeneration	activates	disease	0.60
PVALB	associated_with	gene	0.60
SST	associated_with	gene	0.60
TPR	associated_with	gene	0.60
neurodegeneration	associated_with	disease	0.60
MKI67	associated_with	gene	0.60
MKI67	interacts_with	gene	0.60
ASTROCYTES	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
TRAK1	regulates	gene	0.60
Apoptosis	activates	pathway	0.60
P16	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
ALS	activates	gene	0.60
MOTOR NEURONS	activates	gene	0.60
AXONAL MITOCHONDRIAL TRANSPORT	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
TRAK1	activates	gene	0.60
AXON REGENERATION	activates	gene	0.60
MICROTUBULES	interacts_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NORMAL TENSION GLAUCOMA	activates	gene	0.60

Incoming (48)

Source	Relation	Type	Str
TRAK1	interacts_with	protein	0.90
TRAK1	binds	protein	0.90
TRAK2	inhibits	protein	0.85
MYO5A	interacts_with	gene	0.60
NCOA4	interacts_with	gene	0.60
CDKN2A	interacts_with	gene	0.60
RET	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
OPTINEURIN	activates	gene	0.60
OPTN	activates	gene	0.60
KIF15	associated_with	gene	0.60
NEFL	associated_with	gene	0.60
AURKB	interacts_with	gene	0.60
TPR	associated_with	gene	0.60
RANK	therapeutic_target	gene	0.60
CALM1	interacts_with	gene	0.60
NEFH	associated_with	gene	0.60
CDC42	associated_with	gene	0.60
GAP43	associated_with	gene	0.60
AURKB	associated_with	gene	0.60
AXON	interacts_with	gene	0.60
NORMAL TENSION GLAUCOMA	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
MICROTUBULES	interacts_with	gene	0.60
ALS	activates	gene	0.60
AND	activates	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
AXONAL MITOCHONDRIAL TRANSPORT	interacts_with	gene	0.60
TRAK1	activates	gene	0.60
MOTOR NEURONS	activates	gene	0.60
AXON REGENERATION	activates	gene	0.60
GENES	associated_with	gene	0.60
GLAUCOMA	activates	gene	0.60
HNRNPA2B1	interacts_with	gene	0.55
KIF5A	interacts_with	gene	0.55
KIF1A	interacts_with	gene	0.55
KIF15	interacts_with	gene	0.50
NEFH	interacts_with	gene	0.50
OPTN	interacts_with	gene	0.50
PVALB	associated_with	gene	0.50
CALM1	associated_with	gene	0.50
PVALB	interacts_with	gene	0.50
GAP43	co_expressed_with	protein	0.50
KIF15	co_expressed_with	gene	0.50
GENES	regulates	gene	0.50
Neurodegeneration	activates	disease	0.50
ASPM	associated_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

KIF5B

Understanding Entity Pages

Summary

Wiki Pages (19)

KIF5B Gene

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

Kinesin-1 Heavy Chain Protein

KLC1 — Kinesin Light Chain 1

Advanced Cytoskeletal Dynamics Modulator Therapy for Neurodegeneration

Axonal Transport Dysfunction in Progressive Supranuclear Palsy

Axonal Transport

Kinesin-1 Heavy Chain Protein

MYO5A — Myosin Va

KIF5A Gene

MAP7 - Microtubule Associated Protein 7

TUBB4B - Tubulin Beta 4B Class IIa

MAP7 Protein

KIF15 Gene - Kinesin Family Member 15

AURKB Gene

KIF5C Protein

KIF5C Gene