gene

KIF5A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KIF5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

79Connections

0Hypotheses

0Analyses

50Outgoing

23Incoming

Summary

KIF5A is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, regulates. Associated with Als, Amyotrophic Lateral Sclerosis, Ms. Connected to 24 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	KIF5A
Chromosome	12q13.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Neurons (CNS and PNS), particularly in axons
Molecular Weight	103 kDa
Amino Acids	350 aa
Pathways	Cargo Transport, Intracellular Transport, autophagic flux, lysosomal axonal transport, ubiquitin-proteasome
UniProt ID	P33175
NCBI Gene ID	3790
Ensembl ID	ENSG00000130224
OMIM	176602
GeneCards	KIF5A
Human Protein Atlas	KIF5A
Symbol [@jnk2005] KIF5A [@kifa2019] [@kifa2003] [@kifa2011] Full Name [@mitochondrial2012] Kinesin Family Member 5A [@axonal2011] Chromosome	12q13.3
Associated Diseases	Als, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ms, Spastic Paraplegia Type 10, disease
Known Drugs/Compounds	TMT
Interactions	KIF5C, Kinesin, KIF5B, NEK1, TBK1, NEUROTOXICITY
KG Connections	79 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KIF5A — AlphaFold P33175 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    KIF5A["<b>KIF5A</b>"]
    PRV["PRV"]
    KIF5A -->|"interacts with"| PRV
    lysosomal_axonal_transport(["lysosomal axonal transport"])
    KIF5A -->|"regulates"| lysosomal_axonal_transport
    autophagic_flux(["autophagic flux"])
    KIF5A -->|"regulates"| autophagic_flux
    Als{"Als"}
    KIF5A -->|"associated with"| Als
    Ms{"Ms"}
    KIF5A -->|"associated with"| Ms
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    KIF5A -->|"associated with"| Amyotrophic_Lateral_Sclerosis
    KIF5C["KIF5C"]
    KIF5A -->|"interacts with"| KIF5C
    MITOCHONDRIA["MITOCHONDRIA"]
    KIF5A -->|"contributes to"| MITOCHONDRIA
    Neuron["Neuron"]
    KIF5A -->|"expressed in"| Neuron
    neurodegeneration["neurodegeneration"]
    KIF5A -->|"implicated in"| neurodegeneration
    TMT["TMT"]
    TMT -->|"inhibits"| KIF5A
    KIF5C -->|"interacts with"| KIF5A
    P62["P62"]
    P62 -->|"associated with"| KIF5A
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    AMYOTROPHIC_LATERAL_SCLEROSIS -->|"associated with"| KIF5A
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"associated with"| KIF5A
    ALS["ALS"]
    ALS -->|"associated with"| KIF5A
    MITOCHONDRIA -->|"contributes to"| KIF5A
    NEURON["NEURON"]
    NEURON -->|"contributes to"| KIF5A
    TRAK1["TRAK1"]
    TRAK1 -->|"regulates"| KIF5A
    TRAK1 -->|"associated with"| KIF5A
    AND["AND"]
    AND -->|"interacts with"| KIF5A
    style KIF5A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (56)

Target	Relation	Type	Str
Intracellular Transport	involved_in	process	0.95
Spastic Paraplegia Type 10	associated_with	disease	0.95
TRAK2	interacts_with	protein	0.90
Mitochondria	transports	cell_type	0.90
Cargo Transport	involved_in	process	0.90
Spastic Paraplegia Type 10	causes	disease	0.90
cargo binding domain	associated_with	protein	0.90
mitochondria	interacts_with	cell_type	0.90
TRAK2	binds	protein	0.85
PRV	interacts_with	entity	0.80
Cargo Binding Domain	mediates	mechanism	0.80
myoclonic seizures	causes	phenotype	0.80
progressive leukoencephalopathy	causes	disease	0.80
lysosomal axonal transport	regulates	process	0.70
autophagic flux	regulates	process	0.70
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
KIF5C	interacts_with	gene	0.60
Kinesin	interacts_with	protein	0.60
Kinesin	associated_with	protein	0.60
epilepsy	interacts_with	disease	0.60
epilepsy	associated_with	disease	0.60
MFSD8	implicated_in	gene	0.60
NEK1	implicated_in	gene	0.60
TBK1	implicated_in	gene	0.60
TBP	implicated_in	gene	0.60
NTRK2	associated_with	gene	0.60
TPM3	associated_with	gene	0.60
TPR	associated_with	gene	0.60
NEK1	interacts_with	gene	0.60
TBK1	interacts_with	gene	0.60
MITOCHONDRIA	contributes_to	gene	0.60
NEUROTOXICITY	activates	gene	0.60
Autophagy	inhibits	pathway	0.60
AND	interacts_with	gene	0.60
TRAK1	regulates	gene	0.60
NEURON	contributes_to	gene	0.60
Neuron	contributes_to	cell_type	0.60
TRAK1	associated_with	gene	0.60
Raf	interacts_with	protein	0.60
neurons	expressed_in	cell_type	0.60
oxidative stress response	participates_in	pathway	0.60
KIF5B	interacts_with	gene	0.55
prion disease	interacts_with	disease	0.55
Neuron	expressed_in	cell_type	0.55
TRAK1	activates	gene	0.55
astrocytes	expressed_in	cell_type	0.55
Alzheimer's disease	associated_with	disease	0.55
ubiquitin-proteasome	participates_in	pathway	0.55

Incoming (23)

Source	Relation	Type	Str
TRAK1	binds	protein	0.85
TMT	inhibits	drug	0.70
KIF5C	interacts_with	gene	0.60
P62	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
CCNF	implicated_in	gene	0.60
CTSF	implicated_in	gene	0.60
DNAJC7	implicated_in	gene	0.60
GLT8D1	implicated_in	gene	0.60
C21ORF2	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
ALS	associated_with	gene	0.60
MITOCHONDRIA	contributes_to	gene	0.60
NEURON	contributes_to	gene	0.60
TRAK1	regulates	gene	0.60
TRAK1	associated_with	gene	0.60
LYSOSOME	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
TRAK1	binds_to	protein	0.60
AND	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
HNRNPA2B1	interacts_with	gene	0.55
MITOCHONDRIA	associated_with	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

KIF5A

Understanding Entity Pages

Summary

Wiki Pages (21)

KIF5A Gene

Novel Therapy Index

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

Astrocytes

Kinesin-1 Heavy Chain Protein

Retrograde Axonal Transport Dysfunction in Neurodegeneration

Axonal Transport Rescue Therapy for Neurodegeneration

KIF28P — Kinesin Family Member 28, Pseudogene

hereditary-spastic-paraplegia

TUBB2A — Tubulin Beta 2A Class IIa

KLC1 — Kinesin Light Chain 1

Astrocytes in Neurodegeneration

TUBB2B — Tubulin Beta 2B Class IIb

Antisense Oligonucleotide Therapy for Neurodegeneration

Axonal Transport Defects in Neurodegenerative Diseases

Advanced Cytoskeletal Dynamics Modulator Therapy for Neurodegeneration

DYNC1LI1 — Dynein Cytoplasmic 1 Light Intermediate Chain 1

PSP Therapeutic Ideas