concept

TRAK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRAK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

121Connections

1Hypotheses

0Analyses

50Outgoing

42Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	TRAK1
Key Genes/Proteins	Dynein, OPTN, KIF5B, Dynein/Dynactin Complex, Actr1A, MIRO1
Related Diseases	axon outgrowth, Axonal Outgrowth
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    TRAK1["TRAK1"]
    TRAK1 -->|"activates"| Ischemia["Ischemia"]
    TRAK1 -->|"activates"| Ms["Ms"]
    TRAK1 -->|"activates"| Stroke["Stroke"]
    TRAK1 -->|"activates"| Hypertension["Hypertension"]
    TRAK1 -->|"activates"| Als["Als"]
    TRAK1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    TRAK1 -->|"activates"| Glaucoma["Glaucoma"]
    TRAK1 -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    TRAK1 -->|"regulates"| MIRO1["MIRO1"]
    TRAK1 -->|"activates"| Apoptosis["Apoptosis"]
    OPTN["OPTN"] -->|"binds"| TRAK1
    MIRO1 -->|"binds"| TRAK1
    MITOCHONDRIA["MITOCHONDRIA"] -->|"interacts"| TRAK1
    AXON["AXON"] -->|"interacts"| TRAK1
    KIF5B["KIF5B"] -->|"regulates"| TRAK1
    ASTROCYTES["ASTROCYTES"] -->|"activates"| TRAK1
    CD38["CD38"] -->|"regulates"| TRAK1
    APOPTOSIS["APOPTOSIS"] -->|"activates"| TRAK1
    NEURON["NEURON"] -->|"interacts"| TRAK1

Outgoing (79)

Target	Relation	Type	Str
Mitochondrial Trafficking	regulates	process	0.95
Dynein	binds	protein	0.95
mitochondrial trafficking	mediates	process	0.95
KIF5B	interacts_with	protein	0.90
KIF5B	binds	protein	0.90
Dynein/Dynactin Complex	binds	protein	0.90
Axon	expressed_in	cell_type	0.90
Axonal Mitochondrial Transport	mediates	process	0.90
Actr1A	binds	protein	0.90
axon outgrowth	associated_with	phenotype	0.90
mitochondria	binds	cell_type	0.90
Axonal Outgrowth	regulates	phenotype	0.85
Cargo Transport	involved_in	process	0.85
KIF5A	binds	protein	0.85
TRAK2	associated_with	protein	0.75
Ischemia	activates	disease	0.65
Ms	activates	disease	0.65
Stroke	activates	disease	0.65
Hypertension	activates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Glaucoma	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
MIRO1	regulates	gene	0.60
Apoptosis	activates	pathway	0.60
KIF5A	regulates	gene	0.60
MITOCHONDRIA	transports	gene	0.60
DYNACTIN	interacts_with	gene	0.60
DYNEIN	interacts_with	gene	0.60
Axonal Transport	transports	pathway	0.60
KIF5A	associated_with	gene	0.60
KIF5C	associated_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
AXON	interacts_with	gene	0.60
AXON REGENERATION	activates	gene	0.60
OPTN	activates	gene	0.60
MOTOR NEURONS	activates	gene	0.60
AND	activates	gene	0.60
KIF5B	activates	gene	0.60
OPTINEURIN	activates	gene	0.60
AXONAL MITOCHONDRIAL TRANSPORT	interacts_with	gene	0.60
MICROTUBULES	interacts_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NORMAL TENSION GLAUCOMA	activates	gene	0.60
KIF5A	binds_to	protein	0.60
mitochondria	interacts_with	cell_type	0.60
axon outgrowth	involved_in	pathway	0.60
axons	expressed_in	brain_region	0.60
axonal mitochondrial motility	involved_in	pathway	0.60
NEURON	interacts_with	gene	0.60

Incoming (42)

Source	Relation	Type	Str
OPTN	interacts_with	protein	0.95
OPTN	binds	gene	0.90
MIRO1	binds	protein	0.90
MITOCHONDRIA	interacts_with	gene	0.70
AXON	interacts_with	gene	0.70
KIF5B	regulates	gene	0.60
ASTROCYTES	activates	gene	0.60
CD38	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
NEURON	interacts_with	gene	0.60
NEURON	transports	gene	0.60
DYNACTIN	interacts_with	gene	0.60
KIF5C	associated_with	gene	0.60
NORMAL TENSION GLAUCOMA	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
MICROTUBULES	interacts_with	gene	0.60
KIF5B	activates	gene	0.60
ALS	activates	gene	0.60
MOTOR NEURONS	activates	gene	0.60
AXONAL MITOCHONDRIAL TRANSPORT	interacts_with	gene	0.60
OPTN	activates	gene	0.60
AND	activates	gene	0.60
OPTINEURIN	activates	gene	0.60
AXON REGENERATION	activates	gene	0.60
KIF5A	regulates	gene	0.60
AND	regulates	gene	0.60
DYNEIN	interacts_with	gene	0.60
MITOCHONDRIA	transports	gene	0.60
AND	interacts_with	gene	0.60
KIF5A	associated_with	gene	0.60
GLAUCOMA	activates	gene	0.60
KIF5A	activates	gene	0.55
KIF5A	interacts_with	gene	0.50
MITOCHONDRIA	associated_with	cell_type	0.50
AXON	associated_with	concept	0.50
KINESIN-1	interacts_with	protein	0.50
KIF5C	interacts_with	protein	0.50
KIF5B	interacts_with	gene	0.50
Neurodegeneration	activates	disease	0.50
Hypertension	activates	disease	0.50
MIRO1	interacts_with	protein	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m	0.348	neurodegeneration	Mitochondrial transfer between astrocyte

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (14)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
KIF5A de novo mutation associated with myoclonic seizures and neonatal onset pro [PMID:27414745]	Rydzanicz M, Jagła M, Kosinska J, Tomasi	Clin Genet	2017	1
TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and [PMID:23395375]	van Spronsen M, Mikhaylova M, Lipka J, S	Neuron	2013	1
Delineation of the TRAK binding regions of the kinesin-1 motor proteins. [PMID:24161670]	Randall TS, Moores C, Stephenson FA	FEBS Lett	2013	1
Therapeutic developments in pancreatic cancer. [PMID:37798442]	["Hu Z", "O'Reilly E"]	Nature reviews. Gastroenterolo	2024	0
Defining treatment-resistant depression. [PMID:31638723]	["Gaynes B", "Lux L", "Gartlehner G", "A	Depression and anxiety	2020	0
Emerging trends in global freshwater availability. [PMID:29769728]	["Rodell M", "Famiglietti J", "Wiese D",	Nature	2018	0
Acute Heart Failure: Definition, Classification and Epidemiology. [PMID:28785969]	["Kurmani S", "Squire I"]	Current heart failure reports	2017	0
Invasive ductal carcinoma: relationship between pathological characteristics and [PMID:28658335]	["Aquino R", "Vasques P", "Cavalcante D"	Revista do Colegio Brasileiro	2017	0
The Impact of Intergenerational Cultural Dissonance on Alcohol Use Among Vietnam [PMID:26598062]	["Kane J", "Johnson R", "Robinson C", "J	The Journal of adolescent heal	2016	0
A proliferative burst during preadolescence establishes the final cardiomyocyte [PMID:24813607]	["Naqvi N", "Li M", "Calvert J", "Tejada	Cell	2014	0
Human plasma glycome in attention-deficit hyperactivity disorder and autism spec [PMID:20974899]	["Pivac N", "Knezevi\u0107 A", "Gornik O	Molecular & cellular proteomic	2011	0
The Crumbs complex: from epithelial-cell polarity to retinal degeneration. [PMID:19625503]	["Bulgakova N", "Knust E"]	Journal of cell science	2009	0
CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell [PMID:18971423]	["Landsman L", "Bar-On L", "Zernecke A",	Blood	2009	0
GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins [PMID:15644324]	Brickley K, Smith MJ, Beck M, Stephenson	The Journal of biological chem	2005	0

TRAK1

Understanding Entity Pages

Wiki Pages (20)

Astrocytes

Dynactin Protein

Axonal Transport Rescue Therapy for Neurodegeneration

KIF28P — Kinesin Family Member 28, Pseudogene

Dynactin Protein

Adenosine Signaling in Neurodegeneration

OPTN Protein (Optineurin)

Astrocytes in Neurodegeneration

Axonal Transport Defects in Neurodegenerative Diseases

AMPK Signaling in Neurodegeneration

PSP Therapeutic Ideas

Therapeutic Antibody Comparison Matrix

Astrocytes in Amyotrophic Lateral Sclerosis

RHOT2 Gene

Miro1 Protein

PSP/CBS Therapeutic Target Index

DISC1 — Disrupted in Schizophrenia 1

Astrocytes in Brain Homeostasis