Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PRION DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PRION DISEASE is a concept in neurodegeneration research. Key relationships include: co discussed, causes, regulates. Associated with ALZHEIMER, ALZHEIMER'S, AMYOTROPHIC LATERAL SCLEROSIS. Connected to 20 entities in the SciDEX knowledge graph.
| Name | PRION DISEASE |
| Key Genes/Proteins | SLC6A3, SNCA, UBIQUITIN, PARKIN, CYP46A1 |
| Related Diseases | NEURODEGENERATION, ISCHEMIA, ALZHEIMER'S, HUNTINGTON'S, PARKINSON'S |
| Related Pathways | UNFOLDED PROTEIN RESPONSE |
Knowledge base pages for this entity
graph TD
PRION_DISEASE["<b>PRION DISEASE</b>"]
PRION_DISEASE -->|"expressed in"| Amyloid["Amyloid"]
PRION_DISEASE -->|"regulates"| Cell_Cycle["Cell Cycle"]
oxidative_stress["oxidative stress"] -->|"causes"| PRION_DISEASE
CX3CR1["CX3CR1"] -->|"contributes to"| PRION_DISEASE
TREM2["TREM2"] -->|"contributes to"| PRION_DISEASE
PI3K["PI3K"] -->|"regulates"| PRION_DISEASE
AKT["AKT"] -->|"regulates"| PRION_DISEASE
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"regulates"| PRION_DISEASE
PARKINSON["PARKINSON"] -->|"regulates"| PRION_DISEASE
SYNAPSE["SYNAPSE"] -->|"regulates"| PRION_DISEASE
AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"causes"| PRION_DISEASE
MICROGLIA["MICROGLIA"] -->|"activates"| PRION_DISEASE
GENES["GENES"] -->|"activates"| PRION_DISEASE| Target | Relation | Type | Str |
|---|---|---|---|
| NEURODEGENERATION | causes | disease | 0.65 |
| UNFOLDED PROTEIN RESPONSE | produces | pathway | 0.65 |
| UNFOLDED PROTEIN RESPONSE | causes | pathway | 0.65 |
| SLC6A3 | associated_with | gene | 0.60 |
| SNCA | associated_with | gene | 0.60 |
| UBIQUITIN | regulates | gene | 0.60 |
| CYP46A1 | associated_with | gene | 0.50 |
| TRAZODONE | associated_with | drug | 0.45 |
| METFORMIN | associated_with | drug | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NEURON | accumulates_in | cell_type | 0.65 |
| NEURODEGENERATION | interacts_with | disease | 0.65 |
| ISCHEMIA | inhibits | disease | 0.65 |
| ISCHEMIA | causes | disease | 0.65 |
| ALZHEIMER'S | causes | disease | 0.60 |
| HUNTINGTON'S | causes | disease | 0.60 |
| PARKIN | causes | gene | 0.60 |
| PARKINSON'S | causes | disease | 0.60 |
| UNFOLDED PROTEIN RESPONSE | associated_with | pathway | 0.45 |
| ALZHEIMER | co_discussed | disease | 0.40 |
| ALZHEIMER'S | co_discussed | disease | 0.40 |
| HUNTINGTON | co_discussed | disease | 0.40 |
| HUNTINGTON'S | co_discussed | disease | 0.40 |
| AMYOTROPHIC LATERAL SCLEROSIS | co_discussed | disease | 0.40 |
| DEMENTIA | co_discussed | disease | 0.40 |
| FRONTOTEMPORAL | co_discussed | disease | 0.40 |
| NEURON | co_discussed | cell_type | 0.40 |
| NEURONS | co_discussed | cell_type | 0.40 |
| PARKIN | co_discussed | gene | 0.40 |
| PARKINSON | co_discussed | disease | 0.40 |
| PARKINSON'S | co_discussed | disease | 0.40 |
| CJD | co_discussed | disease | 0.40 |
| NEURODEGENERATION | co_discussed | disease | 0.40 |
| ALS | co_discussed | disease | 0.40 |
| ALZHEIMER'S DISEASE | co_discussed | disease | 0.40 |
| PARKINSON'S DISEASE | co_discussed | disease | 0.40 |
| MICROGLIA | co_discussed | cell_type | 0.40 |
| CX3CL1 | co_discussed | gene | 0.40 |
| CX3CR1 | co_discussed | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||