Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| ATG8 | activates | protein | 0.64 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Discovery of an APP-selective BACE1 inhibitor for Alzheimer's disease. [PMID:40399225] | Unknown | Neurotherapeutics : the journa | 2025 | 0 |
| Discovery of an APP-selective BACE1 inhibitor for Alzheimer's disease. [PMID:40399225] | Campagna, Jagodzinska, Wi, Zhu, Lee et a | Neurotherapeutics : the journa | 2025 | 0 |
| Amyloid fibrils of the myelin basic protein are an integral component of myelin [PMID:40781105] | Sysoev EI, Shenfeld AA, Belashova TA | Sci Rep | 2025 | 0 |
| Licochalcone A prevents cognitive decline in a lipopolysaccharide-induced neuroi [PMID:39930360] | Carrasco M, Guzman L, Olloquequi J, Cano | Molecular medicine (Cambridge, | 2025 | 0 |
| β-asarone improves cognitive impairment and alleviates autophagy in mice with va [PMID:38039902] | Ning, Zhong, Wu, Wang, Hu et al. | Phytomedicine : international | 2024 | 0 |
| Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, [PMID:39023138] | Bagheri H, Friedman H, Hadwen A | Glia | 2024 | 0 |
| β-asarone improves cognitive impairment and alleviates autophagy in mice with va [PMID:38039902] | Unknown | Phytomedicine : international | 2024 | 0 |
| Pathological remodeling of reactive astrocytes: Involvement of DNA methylation a [PMID:38943350] | Cuautle DG, Donna S, Cieri MB, Villarrea | Journal of neurochemistry | 2024 | 0 |
| Myelin basic protein and index for neuro-Behçet's disease. [PMID:36907539] | Zhan H, Cheng L, Wang X | Clin Immunol | 2023 | 0 |
| The Effect of Mindfulness-based Programs on Cognitive Function in Adults: A Syst [PMID:34350544] | Whitfield, Barnhofer, Acabchuk, Cohen, L | Neuropsychology review | 2022 | 0 |
| Multiple sclerosis and myelin basic protein: insights into protein disorder and [PMID:34889995] | Martinsen V, Kursula P | Amino Acids | 2022 | 0 |
| The Effect of Mindfulness-based Programs on Cognitive Function in Adults: A Syst [PMID:34350544] | Whitfield Tim; Barnhofer Thorsten; Acabc | Neuropsychology review | 2021 | 0 |
| An update on diagnostic and prognostic biomarkers for traumatic brain injury. [PMID:29338452] | Unknown | Expert review of molecular dia | 2019 | 0 |
| An update on diagnostic and prognostic biomarkers for traumatic brain injury. [PMID:29338452] | Unknown | Expert review of molecular dia | 2019 | 0 |
| An updated histological classification system for multiple sclerosis lesions. [PMID:27988845] | Kuhlmann T, Ludwin S, Prat A | Acta Neuropathol | 2017 | 0 |
| What do your eyes reveal about your foreign language? Reading emotional sentence [PMID:28973016] | Iacozza Sara; Costa Albert; Duñabei | PloS one | 2017 | 0 |
| What do your eyes reveal about your foreign language? Reading emotional sentence [PMID:28973016] | ["Iacozza, Sara", "Costa, Albert", "Du\u | PloS one | 2017 | 0 |
| Oligodendroglia metabolically support axons and contribute to neurodegeneration. [PMID:22801498] | Lee Y, Morrison BM, Li Y, Lengacher S, F | Nature | 2012 | 0 |
| A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-lin [PMID:21944779] | Unknown | Neuron | 2011 | 0 |
| Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chro [PMID:21944778] | ["DeJesus-Hernandez Mariely", "Mackenzie | Neuron | 2011 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning LAP in their description or question text
Score: 0.614 · neurodegeneration · 2026-04-25
Persistent damaged mitochondria sustain senescence and inflammatory signaling because selective mitochondrial clearance
Score: 0.610 · neurodegeneration · 2026-04-22
## Mechanistic Overview H2: H3K9me3 Heterochromatin Collapse Enables Cryptic Transcription of Repetitive Elements starts
Score: 0.560 · neurodegeneration · 2026-05-03
Pericyte-to-fibroblast transition contributes to BBB breakdown and impairs glymphatic clearance. Chronic PDGFRβ signalin
Score: 0.531 · als · 2026-04-27
This hypothesis proposes that loss-of-function mutations in TBK1 contribute to ALS pathogenesis primarily through disrup
Score: 0.512 · alzheimer · 2026-04-24
## Mechanistic Overview Myelin Breakdown-Amyloid Interaction Amplifies Cortical Aging-Neurodegeneration Overlap starts f
Score: 0.455 · neurodegeneration · 2026-04-27
Age-dependent oxidation and deamidation of synaptic mitochondrial proteins (including VDAC1, CypD/PPID, and MICOS comple
Score: 0.363 · neurodegeneration · 2026-04-18
## Mechanistic Overview Ferroptosis as Epiphenomenon of Terminal Collapse starts from the claim that modulating not yet