RUBCN

Understanding Entity Pages

This page aggregates everything SciDEX knows about RUBCN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

RUBCN is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with AD, ADH, AMI. Connected to 170 entities in the SciDEX knowledge graph.

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flowchart TD
    RUBCN["RUBCN<br/>(Rubicon)"]
    
    %% Core autophagy pathway
    RUBCN --|"regulates"|--> AUTOPHAGY["Autophagy<br/>Pathway"]
    RUBCN --|"activates"|--> LYSO_DEG["Lysosomal<br/>Degradation"]
    RUBCN --|"associated_with"|--> LC3["LC3<br/>(Autophagosome<br/>Marker)"]
    RUBCN --|"associated_with"|--> NBR1["NBR1<br/>(Autophagy<br/>Receptor)"]
    RUBCN --|"activates"|--> UVRAG["UVRAG<br/>(Autophagy<br/>Regulator)"]
    
    %% mTOR signaling
    RUBCN --|"regulates"|--> MTOR["mTOR<br/>Pathway"]
    RUBCN --|"regulates"|--> RPS6["RPS6<br/>(Ribosomal<br/>Protein)"]
    MTOR --|"inhibits"|--> AUTOPHAGY
    
    %% Metabolic regulation
    RUBCN --|"associated_with"|--> LIPID_MET["Lipid<br/>Metabolism"]
    RUBCN --|"regulates"|--> SREBF1["SREBF1<br/>(Lipid<br/>Transcription)"]
    RUBCN --|"associated_with"|--> MET_SYN["Metabolic<br/>Syndrome"]
    
    %% Neurodegeneration outcomes
    RUBCN --|"associated_with"|--> PARKINSON["Parkinson's<br/>Disease"]
    RUBCN --|"activates"|--> ALS["ALS<br/>(Motor Neuron<br/>Disease)"]
    RUBCN --|"regulates"|--> ISCHEMIA["Cerebral<br/>Ischemia"]
    
    %% Additional regulatory mechanisms
    RUBCN --|"regulates"|--> EGFR["EGFR<br/>(Growth Factor<br/>Receptor)"]
    RUBCN --|"activates"|--> SMURF1["SMURF1<br/>(E3 Ligase)"]
    RUBCN --|"associated_with"|--> APOPTOSIS["Apoptosis<br/>Pathway"]
    
    %% Pathway connections
    AUTOPHAGY --|"dysfunction"|--> PARKINSON
    AUTOPHAGY --|"impaired"|--> ALS
    LIPID_MET --|"dysregulation"|--> MET_SYN
    
    style RUBCN fill:#006494
    style AUTOPHAGY fill:#1b5e20
    style LYSO_DEG fill:#1b5e20
    style MTOR fill:#4a1a6b
    style PARKINSON fill:#5d4400
    style ALS fill:#5d4400
    style MET_SYN fill:#ef5350
    style APOPTOSIS fill:#ef5350
    style LC3 fill:#4a1a6b
    style UVRAG fill:#4a1a6b
    style SREBF1 fill:#4a1a6b