gene

RUBCN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RUBCN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

345Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

6Experiments

3Debates

Summary

RUBCN is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with AD, ADH, AMI. Connected to 170 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RUBCN
Function	VPS34/BECN1 complex inhibition: Rubicon directly binds the BECN1-VPS34-UVRAG-VPS15 complex (Class III PI3K complex II) through its RUN domain, suppressing VPS34 lipid kinase activity and reducing PI3P
Pathways	PI3K
Ensembl ID	ENSG00000145016
GeneCards	RUBCN
Human Protein Atlas	RUBCN
Associated Diseases	AD, ADH, AMI, disease, Ischemia, Lupus
Known Drugs/Compounds	rapamycin
Interactions	ACAT1, AMPK, AND, ATG, ATP, AUTOPHAGY
KG Connections	345 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RUBCN Gene

gene · 790 words

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Pathway Diagram

flowchart TD
    RUBCN["RUBCN
(Rubicon)"]
    
    %% Core autophagy pathway
    RUBCN -->|"regulates"| AUTOPHAGY["Autophagy
Pathway"]
    RUBCN -->|"activates"| LYSO_DEG["Lysosomal
Degradation"]
    RUBCN -->|"associated_with"| LC3["LC3
(Autophagosome
Marker)"]
    RUBCN -->|"associated_with"| NBR1["NBR1
(Autophagy
Receptor)"]
    RUBCN -->|"activates"| UVRAG["UVRAG
(Autophagy
Regulator)"]
    
    %% mTOR signaling
    RUBCN -->|"regulates"| MTOR["mTOR
Pathway"]
    RUBCN -->|"regulates"| RPS6["RPS6
(Ribosomal
Protein)"]
    MTOR -->|"inhibits"| AUTOPHAGY
    
    %% Metabolic regulation
    RUBCN -->|"associated_with"| LIPID_MET["Lipid
Metabolism"]
    RUBCN -->|"regulates"| SREBF1["SREBF1
(Lipid
Transcription)"]
    RUBCN -->|"associated_with"| MET_SYN["Metabolic
Syndrome"]
    
    %% Neurodegeneration outcomes
    RUBCN -->|"associated_with"| PARKINSON["Parkinson's
Disease"]
    RUBCN -->|"activates"| ALS["ALS
(Motor Neuron
Disease)"]
    RUBCN -->|"regulates"| ISCHEMIA["Cerebral
Ischemia"]
    
    %% Additional regulatory mechanisms
    RUBCN -->|"regulates"| EGFR["EGFR
(Growth Factor
Receptor)"]
    RUBCN -->|"activates"| SMURF1["SMURF1
(E3 Ligase)"]
    RUBCN -->|"associated_with"| APOPTOSIS["Apoptosis
Pathway"]
    
    %% Pathway connections
    AUTOPHAGY -->|"dysfunction"| PARKINSON
    AUTOPHAGY -->|"impaired"| ALS
    LIPID_MET -->|"dysregulation"| MET_SYN
    
    style RUBCN fill:#006494
    style AUTOPHAGY fill:#1b5e20
    style LYSO_DEG fill:#1b5e20
    style MTOR fill:#4a1a6b
    style PARKINSON fill:#5d4400
    style ALS fill:#5d4400
    style MET_SYN fill:#ef5350
    style APOPTOSIS fill:#ef5350
    style LC3 fill:#4a1a6b
    style UVRAG fill:#4a1a6b
    style SREBF1 fill:#4a1a6b

Outgoing (195)

Target	Relation	Type	Str
LAP	promotes	process	0.95
Macroautophagy	regulates	process	0.95
Autophagosome-Lysosome Fusion	inhibits	process	0.95
AUTOPHAGY	inhibits	entity	0.95
autophagosome-lysosome fusion	inhibits	process	0.95
VPS34	interacts_with	protein	0.90
Kidney Proximal Tubular Epithelial Cells	expressed_in	cell_type	0.90
LYSOSOME	regulates	entity	0.90
LIPID METABOLISM	regulates	entity	0.85
Metabolism	regulates	process	0.85
Kidney Proximal Tubular Epithelial Cells	involved_in	cell_type	0.85
BECN1	interacts_with	protein	0.85
Proximal Tubular Epithelial Cells	expressed_in	cell_type	0.85
Phospholipid Mobilization	promotes	process	0.80
autophagy	regulates	process	0.80
Metabolic Regulation	regulates	process	0.80
autophagy pathway	participates_in	pathway	0.70
Fatty Acid Transfer	promotes	process	0.70
Mtor	associated_with	pathway	0.70
Autophagy	associated_with	pathway	0.70
LC3	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
Ischemia	regulates	disease	0.65
Ms	regulates	disease	0.65
Metabolic Syndrome	associated_with	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Als	activates	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Lupus	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Metabolic Syndrome	causes	disease	0.65
CPT1A	regulates	gene	0.60
Raf	regulates	protein	0.60
Insulin	regulates	protein	0.60
Actin	regulates	protein	0.60
Fus	regulates	protein	0.60
RUBCNL	activates	gene	0.60
Parkinson's disease	activates	disease	0.60
epigenetic regulation	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
Wnt signaling	participates_in	pathway	0.60
CREBBP	associated_with	gene	0.60
ACTB	regulates	gene	0.60
LAMP1	regulates	gene	0.60
PPARGC1A	regulates	gene	0.60
Cell Cycle	associated_with	pathway	0.60
Chaperone	associated_with	pathway	0.60

Incoming (150)

Source	Relation	Type	Str
lactate	modulates	pathway	0.90
Lipid Metabolism	regulates	process	0.80
BECN1	associated_with	gene	0.70
PIK3C3	regulates	gene	0.70
rapamycin	targets	drug	0.70
ATG	activates	gene	0.70
ATG16L2	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
CDKN1B	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
CTSD	activates	entity	0.60
EGFR	activates	entity	0.60
EIF4EBP1	activates	entity	0.60
LAMP1	activates	entity	0.60
LRP2	activates	entity	0.60
MAP1LC3B	activates	entity	0.60
MTOR	activates	entity	0.60
MYC	activates	entity	0.60
PIK3C3	activates	entity	0.60
PPARA	activates	entity	0.60
PPARG	activates	entity	0.60
PPARGC1A	activates	entity	0.60
RAB7A	activates	entity	0.60
RPS6	activates	entity	0.60
RPS6KB1	activates	entity	0.60
LC3	activates	gene	0.60
RB1	activates	gene	0.60
ATG	regulates	gene	0.60
AMPK	associated_with	gene	0.60
ACAT1	associated_with	gene	0.60
ATG	associated_with	gene	0.60
P53	associated_with	gene	0.60
MTORC1	regulates	gene	0.60
NADH	regulates	gene	0.60
ATP	regulates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
MTORC1	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
CPT1A	regulates	gene	0.60
ATP	activates	gene	0.60
CPT1A	activates	gene	0.60
NADH	activates	gene	0.60
RAS	activates	gene	0.60
HSC70	activates	gene	0.60
BECN1	regulates	gene	0.60
UVRAG	activates	gene	0.60
ACAT1	activates	gene	0.60
CREB	activates	gene	0.60
GSK3	activates	gene	0.60
MAP1LC3	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.453

Experiments (6)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
PTEC-specific RUBCN knockout mice phenotype analysis	validation	kidney injury/metabolic syndro	0.900	PTEC-specific RUBCN knockout m	proposed	N/A
PTEC-specific RUBCN knockout mice phenotyping	validation	acute kidney injury and metabo	0.900	PTEC-specific RUBCN knockout m	proposed	N/A
RUBCN deficiency effects on lipid metabolism in isolated PTECs	exploratory	metabolic dysfunction	0.850	isolated RUBCN-deficient PTECs	proposed	N/A
RUBCN deficiency effects on PTEC lipid metabolism	exploratory	metabolic dysfunction	0.850	cultured RUBCN-deficient PTECs	proposed	N/A
Co-culture analysis of PTEC-hepatocyte fatty acid transfer	exploratory	metabolic syndrome	0.800	PTEC-hepatocyte transwell co-c	proposed	N/A
PTEC-hepatocyte co-culture fatty acid efflux study	exploratory	metabolic syndrome	0.800	PTEC-hepatocyte transwell co-c	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning RUBCN in their description or question text

No additional research found

RUBCN

Understanding Entity Pages

Summary

Wiki Pages (1)

RUBCN Gene

Pathway Diagram

Outgoing (195)

Incoming (150)

Targeting Hypotheses (0)

Mentioning Analyses (1)

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

Experiments (6)

Related Papers (0)

Debates (3)

The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendro

The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendro

The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendro

Related Research