concept

ATG8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

279Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ATG8 is a concept in neurodegeneration research. Key relationships include: interacts with, activates, implicated in. Associated with ALS, Aging, Als. Connected to 128 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ATG8
Key Genes/Proteins	LC3, RAVZ, ATG, AUTOPHAGY
Related Diseases	Cancer, Parkinson, Als
Related Pathways	Non-canonical Autophagy, autophagy pathway, Autophagy

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ATG8["<b>ATG8</b>"]
    ATG8 -->|"interacts"| PE["PE"]
    ATG8 -->|"interacts"| PS["PS"]
    ATG8 -->|"interacts"| Aging["Aging"]
    ATG8 -->|"interacts"| ALS["ALS"]
    ATG8 -->|"interacts"| Cancer["Cancer"]
    ATG8 -->|"activates"| Ms["Ms"]
    ATG8 -->|"activates"| Parkinson["Parkinson"]
    ATG8 -->|"inhibits"| Als["Als"]
    ATG8 -->|"interacts"| LGALS8["LGALS8"]
    ATG8 -->|"regulates"| MTOR["MTOR"]
    ATG8 -->|"interacts"| MAPT["MAPT"]
    ATG["ATG"] -->|"component_of"| ATG8
    NON_CANONICAL_AUTOPHAGY["NON_CANONICAL_AUTOPHAGY"] -->|"regulates"| ATG8
    ATG4["ATG4"] -->|"regulates"| ATG8
    LAP["LAP"] -->|"activates"| ATG8
    G3BP1["G3BP1"] -->|"interacts"| ATG8
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| ATG8
    GABARAP["GABARAP"] -->|"interacts"| ATG8
    LGALS8 -->|"interacts"| ATG8
    RRAGA["RRAGA"] -->|"interacts"| ATG8
    TAU["TAU"] -->|"interacts"| ATG8
    JUN["JUN"] -->|"interacts"| ATG8
    RRAGB["RRAGB"] -->|"interacts"| ATG8

Outgoing (167)

Target	Relation	Type	Str
LC3	interacts_with	gene	1.00
Phosphatidylserine	binds	compound	0.95
Phosphatidylethanolamine	binds	compound	0.95
Autophagy	involved_in	process	0.95
Casm	involved_in	process	0.90
autophagy pathway	participates_in	pathway	0.90
Autophagy	interacts_with	pathway	0.90
AUTOPHAGY	associated_with	gene	0.80
Autophagy	associated_with	pathway	0.80
Cancer	interacts_with	disease	0.75
Parkinson	activates	disease	0.75
Als	regulates	disease	0.75
Als	implicated_in	disease	0.75
PE	interacts_with	protein	0.72
PS	interacts_with	protein	0.72
CANCER	interacts_with	gene	0.70
Autophagy	activates	pathway	0.70
LC3	associated_with	gene	0.70
Lysosomal Degradation	interacts_with	pathway	0.70
Aging	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
ALS	activates	disease	0.65
Ms	activates	disease	0.65
Als	inhibits	disease	0.65
Infection	expressed_in	disease	0.65
Inflammation	implicated_in	disease	0.65
Als	interacts_with	disease	0.65
Infection	regulates	disease	0.65
Bacterial Infection	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Breast Cancer	interacts_with	disease	0.65
Aging	implicated_in	disease	0.65
Infection	activates	disease	0.65
Als	activates	disease	0.65
Als	associated_with	disease	0.65
Tumor	regulates	disease	0.65
Infection	interacts_with	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Ms	regulates	disease	0.65
Ataxia	regulates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
LGALS8	interacts_with	gene	0.60
MTOR	regulates	gene	0.60
MAPT	interacts_with	gene	0.60
JUN	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
ATF4	associated_with	gene	0.60
LYSOSOME	interacts_with	gene	0.60

Incoming (112)

Source	Relation	Type	Str
Non-canonical Autophagy	involved_in	pathway	0.95
Casm	involved_in	process	0.95
RAVZ	cleaves	protein	0.90
ATG	component_of	gene	0.80
AUTOPHAGY	interacts_with	gene	0.80
NON_CANONICAL_AUTOPHAGY	regulates	pathway	0.72
ATG	interacts_with	gene	0.70
PARKINSON	activates	gene	0.70
ATG4	regulates	protein	0.64
LAP	activates	pathway	0.64
G3BP1	interacts_with	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
EIF2A	associated_with	gene	0.60
GABARAP	interacts_with	gene	0.60
LGALS8	interacts_with	gene	0.60
RRAGA	interacts_with	gene	0.60
TAU	interacts_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
JUN	interacts_with	gene	0.60
RRAGB	interacts_with	gene	0.60
LYSOSOME	interacts_with	gene	0.60
FMR1	associated_with	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
PINK1	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
LC3	inhibits	gene	0.60
PARKIN	activates	gene	0.60
DRP1	activates	gene	0.60
ATG7	inhibits	gene	0.60
PTEN	activates	gene	0.60
AUTOPHAGY	causes	gene	0.60
AUTOPHAGY	activates	gene	0.60
NFKB	implicated_in	gene	0.60
MAVS	activates	gene	0.60
SQSTM1	implicated_in	gene	0.60
IKBKE	activates	gene	0.60
SQSTM1	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
SQSTM1	regulates	gene	0.60
P62	regulates	gene	0.60
ENDOSOMES	interacts_with	gene	0.60
PINK1	implicated_in	gene	0.60
MITOPHAGY	implicated_in	gene	0.60
LRRK2	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
APOPTOSIS	regulates	gene	0.60
AND	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
MAP1LC3B	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATG8

Understanding Entity Pages

Summary

Wiki Pages (20)

mitophagy-defect

ZFYVE26 Gene

Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD

Granulovacuolar Bodies: Neuronal Defense Mechanism Against Tau Pathology

EPG5 Gene - Ectopic P-Granules 5 Autophagy Tutor

MAP1LC3A Gene

Autophagy-Lysosomal Pathway

SQSTM1 — Sequestosome 1 (p62)

ATG7 Protein — Autophagy-Related Protein 7

UBQLN1 — Ubiquilin 1

WIPI1 Gene

ATG4B — Autophagy Related 4B Cysteine Peptidase

ATG17A

GABARAP Protein

ATG7 Protein

ATG4C Gene

SQSTM1/p62

ATG3 Gene