entity

LEAD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LEAD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections
0Hypotheses
5Analyses
2Outgoing
0Incoming

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Linked Clinical Trials Program

institution · 2372 words

cbs-psp-daily-action-plan

therapeutic · 30834 words

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

Corticobasal Syndrome (CBS)

disease · 11374 words

Outgoing (11)

TargetRelationTypeStr
APPupregulatesprotein0.88
BACE1upregulatesprotein0.87

Incoming (0)

SourceRelationTypeStr
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (5)

Scientific analyses that reference this entity

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.521

What is the molecular mechanism by which oligodendroglial MCT1 disruption causes

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.614

What upstream mechanisms cause TDP-43 to trigger mPTP opening and can this be th

neurodegeneration | 2026-04-08 | 0 hypotheses

What mechanisms drive TDP-43 pathology specifically in Alzheimer's disease versu

neurodegeneration | 2026-04-07 | 0 hypotheses

What determines the specificity of calcium-dependent PPP3/calcineurin activation

neurodegeneration | 2026-04-07 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found