pathway

necroptosis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about necroptosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1690Connections

0Hypotheses

0Analyses

29Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	necroptosis
Key Genes/Proteins	MMP9, RIPK3, ALS, RIPK1, MLKL
Related Diseases	Alzheimer's disease, ALS
Related Pathways	pyroptosis, ferroptosis

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    necroptosis["necroptosis"] -->|"crosstalk with"| pyroptosis["pyroptosis"]
    style pyroptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    necroptosis["necroptosis"] -->|"active in"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    necroptosis["necroptosis"] -->|"crosstalk with"| unfolded_protein_response["unfolded protein response"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    necroptosis["necroptosis"] -->|"active in"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    necroptosis["necroptosis"] -->|"associated"| Alzheimer_s_disease["Alzheimer's disease"]
    style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    necroptosis["necroptosis"] -->|"activates"| Tau_pathology["Tau pathology"]
    style Tau_pathology fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    necroptosis["necroptosis"] -->|"regulates"| granulovacuolar_neurodegenerat["granulovacuolar neurodegeneration"]
    style granulovacuolar_neurodegenerat fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    MMP9["MMP9"] -->|"associated"| necroptosis["necroptosis"]
    style MMP9 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    PANoptosome["PANoptosome"] -->|"upstream of"| necroptosis["necroptosis"]
    style PANoptosome fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    RIPK3["RIPK3"] -->|"participates in"| necroptosis["necroptosis"]
    style RIPK3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ALS["ALS"] -->|"participates in"| necroptosis["necroptosis"]
    style ALS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    Alzheimer_s_disease_1["Alzheimer's disease"] -->|"involves"| necroptosis["necroptosis"]
    style Alzheimer_s_disease_1 fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    style necroptosis fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (321)

Target	Relation	Type	Str
astrocyte	causes	cell_type	0.95
pyroptosis	crosstalk_with	pathway	0.90
neurons	active_in	cell_type	0.90
neural stem cells	active_in	cell_type	0.90
antitumor immunity	promotes	process	0.90
proinflammatory mediators	upregulates	compound	0.85
tumor immunogenicity	associated_with	phenotype	0.85
Alzheimer's Disease	contributes_to	disease	0.85
hippocampal sclerosis	contributes_to	phenotype	0.85
unfolded protein response	crosstalk_with	pathway	0.80
microglia	active_in	cell_type	0.80
Depression	implicated_in	disease	0.75
Alzheimer's disease	associated_with	disease	0.70
Tau pathology	activates	pathway	0.70
granulovacuolar neurodegeneration	regulates	process	0.70
Tau pathology	associated_with	process	0.70
amyotrophic lateral sclerosis	associated_with	disease	0.70
Parkinson's disease	associated_with	disease	0.70
endothelial cells	active_in	cell_type	0.70
dendritic cells	active_in	cell_type	0.70
oligodendrocytes	active_in	cell_type	0.60
white matter	active_in	brain_region	0.60
T cells	active_in	cell_type	0.60
ubiquitination	activates	process	0.60
neuroinflammation	associated_with	process	0.60
pyroptosis	binds_to	pathway	0.60
monocytes	active_in	cell_type	0.60
pyroptosis	co_mentioned	pathway	0.40
RIPK1	co_mentioned	gene	0.40

Incoming (1369)

Source	Relation	Type	Str
compound 1f	associated_with	compound	0.95
MMP9	associated_with	protein	0.90
PANoptosome	upstream_of	process	0.90
RIPK3	participates_in	gene	0.90
ALS	participates_in	gene	0.90
Alzheimer's disease	involves	disease	0.90
ALS	involves	disease	0.90
RIPK1	participates_in	gene	0.90
MLKL	participates_in	gene	0.90
ferroptosis	crosstalk_with	pathway	0.90
neurodegeneration	involves	disease	0.90
TNF	participates_in	gene	0.90
apoptosis pathway	crosstalk_with	pathway	0.90
apoptosis pathway	mediates	pathway	0.90
oxidative stress response	mediates	pathway	0.90
TNF receptor	activates	receptor	0.90
TNF-α/NF-κB/MAPK signaling pathway	mediates	pathway	0.90
HSYA	inhibits	compound	0.90
RIPK1	promotes	protein	0.90
Nec-1s	suppresses	drug	0.90
RIPK1	drives	protein	0.88
TNF	promotes	protein	0.88
NLRP3	participates_in	gene	0.80
AMPK	participates_in	gene	0.80
DNA	participates_in	gene	0.80
BECN1	participates_in	gene	0.80
SQSTM1	participates_in	gene	0.80
LC3	participates_in	gene	0.80
OPTN	participates_in	gene	0.80
ROS	participates_in	gene	0.80
Parkinson's disease	involves	disease	0.80
neuroinflammation	involves	disease	0.80
traumatic brain injury	involves	disease	0.80
NLR	participates_in	gene	0.80
ERN1	participates_in	gene	0.80
ZBP1	participates_in	gene	0.80
TNFR1	participates_in	gene	0.80
spinal muscular atrophy	involves	disease	0.80
endosome	involved_in	organelle	0.80
Zhenwu Decoction	inhibits	drug	0.80
TREM2	promotes	gene	0.80
Musk	inhibits	drug	0.80
granulovacuolar neurodegeneration	regulates	process	0.70
STING pathway	regulates	pathway	0.70
RIPK1	activates	protein	0.70
MLKL inhibition	protects_against	process	0.70
Lead	activates	drug	0.70
TNF	activates	protein	0.70
RIPK1	regulates	protein	0.70
RIPK3	regulates	protein	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

necroptosis

Understanding Entity Pages

Wiki Pages (21)

necroptosis

cbs-psp-daily-action-plan

Novel Therapy Index

Parthanatos in Neurodegeneration

Alzheimer's Disease Mechanism Index

Therapeutics

deferiprone-neurodegeneration

Ferroptosis in Alzheimer's Disease

Neuronal Ceroid Lipofuscinosis (NCL)

NF-κB Signaling Pathway in Neurodegeneration

Necroptotic Neurons

Tumor Necrosis Factor Alpha (TNF-α) as a Neurodegenerative Disease Biomarker

Ferroptosis in Neurodegeneration

Necroptosis Pathway in Neurodegeneration

Cytochrome c Protein

Neurotrophic Factors in Neurodegeneration

MAPK9 Gene

Neuroinflammation Microglia

university-of-rochester

TFAM Gene

Demyelination

Pathway Diagram

Outgoing (321)

Incoming (1369)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)