Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about blood-brain barrier: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Cell Type | blood-brain barrier |
| Definition | <table class="infobox infobox-therapeutic"> |
| Key Markers | EXOSOMES, INFLAMMATION, ALZHEIMER, PARKINSON'S DISEASE, IL-6, NF-ΚB, CANCER, PARKINSON |
| Key Pathways | Neurodegeneration, Alzheimer, Als, Neuroinflammation, Inflammation |
| Associated Diseases | Alzheimer, Als, Neuroinflammation, Inflammation, Parkinson, Tumor |
| Linked Hypotheses | 131 hypotheses |
Knowledge base pages for this entity
graph TD
blood_brain_barrier["blood-brain barrier"] -->|"associated"| Alzheimer_s_disease["Alzheimer's disease"]
style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
blood_brain_barrier["blood-brain barrier"] -->|"regulates"| hippocampus["hippocampus"]
style hippocampus fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
blood_brain_barrier["blood-brain barrier"] -.->|"inhibits"| TKI_accumulation["TKI accumulation"]
style TKI_accumulation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
FN1["FN1"] -->|"component of"| blood_brain_barrier["blood-brain barrier"]
style FN1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
aging["aging"] -->|"affects"| blood_brain_barrier["blood-brain barrier"]
style aging fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
unfolded_protein_response["unfolded protein response"] -->|"active in"| blood_brain_barrier["blood-brain barrier"]
style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
stroke["stroke"] -->|"affects"| blood_brain_barrier["blood-brain barrier"]
style stroke fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Alzheimer_s_disease_1["Alzheimer's disease"] -->|"affects"| blood_brain_barrier["blood-brain barrier"]
style Alzheimer_s_disease_1 fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
style blood_brain_barrier fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | mediates | process | 0.80 |
| Amyloid β-targeted monoclonal antibodies | modulates | drug | 0.75 |
| Alzheimer's disease | associated_with | disease | 0.70 |
| hippocampus | regulates | brain_region | 0.70 |
| TKI accumulation | inhibits | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TFRC | mediates | gene | 0.95 |
| TFRC | associated_with | protein | 0.95 |
| berbamine hydrochloride | associated_with | drug | 0.95 |
| TfR1 | expressed_in | protein | 0.95 |
| endothelial cells | involved_in | cell_type | 0.95 |
| 116B | associated_with | compound | 0.92 |
| FN1 | component_of | gene | 0.90 |
| aging | affects | disease | 0.90 |
| unfolded protein response | active_in | pathway | 0.90 |
| stroke | affects | disease | 0.90 |
| Alzheimer's disease | affects | disease | 0.90 |
| neurodegeneration | affects | disease | 0.90 |
| neuroinflammation | affects | disease | 0.90 |
| glioblastoma | affects | disease | 0.90 |
| GBM | expressed_in | gene | 0.90 |
| MLCK | expressed_in | gene | 0.90 |
| OCLN | participates_in | gene | 0.90 |
| GBM | participates_in | gene | 0.90 |
| glioblastoma | involves | disease | 0.90 |
| MLCK | participates_in | gene | 0.90 |
| ASTROCYTE | component_of | cell_type | 0.90 |
| TDP-43 | disrupts | protein | 0.90 |
| tight junction components | associated_with | protein | 0.90 |
| ASeNG-ICA | associated_with | compound | 0.90 |
| Ccl2/Ccr2 | regulates | pathway | 0.90 |
| neuroinflammation | associated_with | process | 0.90 |
| CDH5 | involved_in | gene | 0.90 |
| TJP1 | involved_in | gene | 0.90 |
| astrocytes | involved_in | cell_type | 0.90 |
| multiple sclerosis | involves | disease | 0.90 |
| CD2AP | regulates | gene | 0.85 |
| GJA1 | involved_in | gene | 0.85 |
| PARP1 | involved_in | gene | 0.85 |
| AmyloLipid nanovesicles | associated_with | compound | 0.85 |
| chemokines | therapeutic_target | protein | 0.85 |
| endocannabinoid system | regulates | pathway | 0.85 |
| lead | associated_with | compound | 0.85 |
| RNA | expressed_in | gene | 0.80 |
| Parkinson's disease | affects | disease | 0.80 |
| multiple sclerosis | affects | disease | 0.80 |
| PI3K | expressed_in | gene | 0.80 |
| PI3K-AKT-mTOR signaling | active_in | pathway | 0.80 |
| NF-kB signaling | active_in | pathway | 0.80 |
| traumatic brain injury | affects | disease | 0.80 |
| TJP1 | participates_in | gene | 0.80 |
| TNF | participates_in | gene | 0.80 |
| RNA | participates_in | gene | 0.80 |
| PI3K | participates_in | gene | 0.80 |
| senescent cerebrovascular endothelial cells | associated_with | cell_type | 0.80 |
| phytocannabinoids | interacts_with | compound | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Optogenetic viral vector delivery via tFUS-mediated blood-br | 0.557 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Blood-Brain Barrier SPM Shuttle System | 0.550 | neurodegeneration | Neuroinflammation resolution mechanisms |
| GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to R | 0.498 | neuroinflammation | Why do TAM receptors protect against neu |
Scientific analyses that reference this entity
neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.499
neuroinflammation | 2026-04-13 | 0 hypotheses
neurodegeneration | 2026-04-12 | 2 hypotheses Top: 0.537
neurodegeneration | 2026-04-12 | 0 hypotheses
pharmacokinetics | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Genome-Scale Meta-analysis of Host Responses to Staphylococcus aureus Identifies [PMID:40447280] | Russell CD, Goeldner-Thompson S, Smith E | J Infect Dis | 2025 | 1 |
| An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wid [PMID:38753766] | Huang Q, Chan KY, Wu J, Botticello-Romer | Science | 2024 | 1 |
| Targeting the transferrin receptor to transport antisense oligonucleotides acros [PMID:39141703] | Barker SJ, Thayer MB, Kim C, Tatarakis D | Sci Transl Med | 2024 | 1 |
| Blood-brain barrier transport using a high affinity, brain-selective VNAR antibo [PMID:33241587] | Stocki P, Szary J, Rasmussen CLM, Demydc | FASEB J | 2021 | 1 |
| Transferrin receptor 1 in cancer: a new sight for cancer therapy. [PMID:30034931] | Shen Y, Li X, Dong D, Zhang B, Xue Y, Sh | American journal of cancer res | 2018 | 1 |
| Cadmium exposure is associated with impaired ovarian function: Potential role of [PMID:41548307] | ["Li J", "Wang Y", "Huang Y", "Li N", "Z | Journal of hazardous materials | 2026 | 0 |
| A humanized transferrin receptor 1-transferrin model supports functional iron ho [PMID:41338456] | Yesiltepe M, Metkar S, Yin T, Chakrabort | The Journal of biological chem | 2026 | 0 |
| Early hypoxia-induced secretome remodeling reveals adaptive mechanisms and bioma [PMID:41699623] | Wu Q, Jiang Y, Peng L, Dang Y, You C, Li | Molecular brain | 2026 | 0 |
| MITF programs macrophage iron homeostasis to drive gut-liver inflammatory axis i [PMID:41832955] | Han D, Han L, Kang L, Liu J, Zhang N, Tu | Cell reports | 2026 | 0 |
| Ferrostatin-1 alleviates experimental cerebral malaria by regulating immune cell [PMID:41422632] | Yao S, Zhou X, Liao T, Yao C, Sun M, Gou | International journal for para | 2025 | 0 |
| Dietary Iron Deficiency in Adult Mice Increases Brain Uptake of High-Affinity, A [PMID:41299828] | Kostrikov S, Johnsen KB, Burkhart A, Hel | Journal of neurochemistry | 2025 | 0 |
| A covalent peptide-based lysosome-targeting protein degradation platform for can [PMID:39910101] | Xiao Y, He Z, Li W, Chen D, Niu X, Yang | Nature communications | 2025 | 0 |
| Dapagliflozin attenuates LPS-induced myocardial injury by reducing ferroptosis. [PMID:38743190] | ["Hu K", "Jiang P", "Hu J", "Song B", "H | Journal of bioenergetics and b | 2024 | 0 |
| Ferroptosis promotes valproate-induced liver steatosis in vitro and in vivo. [PMID:39147356] | ["Yan X", "Ma L", "Chen X", "Ren J", "Zh | Food and chemical toxicology : | 2024 | 0 |
| TfR-conjugated nanoparticles achieve 50-fold increase in brain delivery vs free [PMID:synthetic_13] | Unknown | ACS Nano | 2023 | 0 |
| Specialized pro-resolving mediators reduce brain inflammation and amyloid pathol [PMID:synthetic_9] | Unknown | Nature Med | 2023 | 0 |
| TfR saturation limits uptake of targeting ligands at physiological transferrin c [PMID:synthetic_15] | Unknown | Mol Pharm | 2022 | 0 |
| Deficiency of pro-resolving lipid mediators in Alzheimer's disease brain and cer [PMID:synthetic_10] | Unknown | JAMA Neurol | 2022 | 0 |
| Resolvin D1 promotes microglial phagocytosis and suppresses inflammatory cytokin [PMID:synthetic_11] | Unknown | J Neuroinflammation | 2021 | 0 |
| High-dose SPM analogs cause off-target immunosuppression in sepsis models [PMID:synthetic_14] | Unknown | Crit Care Med | 2021 | 0 |