concept

LIPOGENESIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LIPOGENESIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

2Hypotheses

1Analyses

4Outgoing

13Incoming

0Experiments

5Debates

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💡 Concept Info

Name	LIPOGENESIS
Related Diseases	FERROPTOSIS, HEPATOCELLULAR CARCINOMA, METASTASIS, NAFLD, OXIDATIVE STRESS
Related Pathways	MTOR SIGNALING, PI3K/AKT/MTOR

Pathway Diagram

graph TD
    LIPOGENESIS[LIPOGENESIS]
    LIPOGENESIS -->|regulates| PI3K_AKT_MTOR[PI3K/AKT/MTOR]
    LIPOGENESIS -->|inhibits| FERROPTOSIS[FERROPTOSIS]
    LIPOGENESIS -->|inhibits| METASTASIS[METASTASIS]
    LIPOGENESIS -->|causes| NAFLD[NAFLD]
    SREBP1[SREBP1] -->|regulates| LIPOGENESIS
    SCD1[SCD1] -->|mediates| LIPOGENESIS
    PXR[PXR] -->|promotes| LIPOGENESIS
    AMPK[AMPK] -->|inhibits| LIPOGENESIS
    mTORC1[mTORC1] -->|activates| LIPOGENESIS
    FERROPTOSIS -->|regulates| LIPOGENESIS
    HEPATOCELLULAR_CARCINOMA[HEPATOCELLULAR CARCINOMA] -->|interacts| LIPOGENESIS
    OXIDATIVE_STRESS[OXIDATIVE STRESS] -->|regulates| LIPOGENESIS

Outgoing (4)

Target	Relation	Type	Str
PI3K/AKT/MTOR	regulates	pathway	0.65
METASTASIS	inhibits	phenotype	0.65
FERROPTOSIS	inhibits	phenotype	0.65
NAFLD	causes	disease	0.65

Incoming (13)

Source	Relation	Type	Str
SREBP1	regulates	protein	0.95
AMPK	inhibits	protein	0.90
PXR	promotes	protein	0.90
SCD1	mediates	gene	0.90
mTORC1	activates	protein	0.80
AMPK	inhibits	protein	0.80
ABCA1 modulators	causes	drug	0.70
HEPATOCELLULAR CARCINOMA	interacts_with	disease	0.65
HEPATOCELLULAR CARCINOMA	activates	disease	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
FERROPTOSIS	regulates	phenotype	0.65
MTOR SIGNALING	associated_with	pathway	0.45
PI3K/AKT/MTOR	associated_with	pathway	0.45

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE4 drives astrocyte metabolic reprogramming toward glycol	0.580	neuroscience	APOE4-driven lipid metabolism dysregulat
Metabolic Rescue PDH Activation (H5): Indirect Lipogenesis S	0.550	neurodegeneration	Does restoring neuronal AMPK activity re