concept

PI3K/AKT/MTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K/AKT/MTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

388Connections

0Hypotheses

0Analyses

50Outgoing

29Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PI3K/AKT/MTOR
Related Diseases	triple-negative breast cancer, Glioblastoma, drug resistance

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PI3K_AKT_MTOR["PI3K/AKT/MTOR"]
    style PI3K_AKT_MTOR fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PI3K_AKT_MTOR -->|"regulates"| Insulin_Resistance(Insulin Resistance)
    PI3K_AKT_MTOR -->|"involved_in"| Glioblastoma["Glioblastoma"]
    PI3K_AKT_MTOR -->|"regulates"| Cell_Proliferation["Cell Proliferation"]
    PI3K_AKT_MTOR -->|"regulates"| Cell_Survival["Cell Survival"]
    PI3K_AKT_MTOR -->|"activates"| multiple_myeloma["multiple myeloma"]
    PI3K_AKT_MTOR -->|"involved_in"| Hormone_Receptor_Positive_Brea["Hormone Receptor-Positive Breast Cancer"]
    PI3K_AKT_MTOR -->|"involved_in"| Breast_Cancer["Breast Cancer"]
    PI3K_AKT_MTOR -->|"involved_in"| Colorectal_Cancer["Colorectal Cancer"]
    PI3K_AKT_MTOR -->|"activates"| Triple_Negative_Breast_Cancer["Triple-Negative Breast Cancer"]
    Gomisin_N["Gomisin N"] -->|"activates"| PI3K_AKT_MTOR
    Paxalisib{"Paxalisib"} -.->|"inhibits"| PI3K_AKT_MTOR
    Cordycepin["Cordycepin"] -.->|"inhibits"| PI3K_AKT_MTOR
    Capivasertib{"Capivasertib"} -.->|"inhibits"| PI3K_AKT_MTOR
    Alpelisib{"Alpelisib"} -.->|"inhibits"| PI3K_AKT_MTOR
    SYK([SYK]) -->|"regulates"| PI3K_AKT_MTOR
    MTOR([MTOR]) -->|"component_of"| PI3K_AKT_MTOR
    BBR{"BBR"} -.->|"inhibits"| PI3K_AKT_MTOR
    Polygonatum_sibiricum_polysacc["Polygonatum sibiricum polysaccharide"] -->|"activates"| PI3K_AKT_MTOR
    Ly294002{"Ly294002"} -.->|"inhibits"| PI3K_AKT_MTOR

Outgoing (193)

Target	Relation	Type	Str
Glioblastoma Metabolism	upregulates	process	0.93
cell proliferation	regulates	process	0.93
triple-negative breast cancer	promotes	disease	0.92
ferritinophagy	regulates	process	0.90
myeloma cell proliferation	activates	process	0.90
myeloma cell survival	promotes	process	0.90
triple-negative breast cancer	regulates	disease	0.90
angiogenesis	promotes	process	0.90
Glioblastoma	upregulates	disease	0.90
Lipid Metabolism	regulates	process	0.90
drug resistance	promotes	phenotype	0.85
Glycolytic Flux	associated_with	process	0.85
Ferroptosis	regulates	process	0.85
Ovarian Follicle	activates	cell_type	0.85
Endometriosis-Associated Ovarian Cancer	involved_in	disease	0.80
GBM	regulates	disease	0.70
DENTATE GYRUS	associated_with	brain_region	0.50
PHAGOCYTOSIS	associated_with	phenotype	0.50
SYK	associated_with	gene	0.50
ALZHEIMER	associated_with	disease	0.50
PDGF	associated_with	gene	0.50
KEAP1	associated_with	gene	0.50
NRF2	associated_with	gene	0.50
GLYCOLYSIS	associated_with	phenotype	0.45
PTEN	associated_with	gene	0.45
AKT	associated_with	gene	0.45
FERROPTOSIS	associated_with	phenotype	0.45
LIPOGENESIS	associated_with	phenotype	0.45
APOPTOSIS	associated_with	phenotype	0.45
BCL2	associated_with	gene	0.45
BAX	associated_with	gene	0.45
ROS	associated_with	phenotype	0.45
CELL DEATH	associated_with	phenotype	0.45
SLC7A11	associated_with	gene	0.45
GPX4	associated_with	gene	0.45
TUMOR GROWTH	associated_with	phenotype	0.45
PIK3CA	associated_with	gene	0.45
CYTOKINES	associated_with	phenotype	0.45
FIBROSIS	associated_with	disease	0.45
AUTOPHAGY	associated_with	phenotype	0.45
SNAP25	associated_with	gene	0.45
CURCUMIN	associated_with	drug	0.45
PARKINSON	associated_with	disease	0.45
TH	associated_with	gene	0.45
NEURONS	associated_with	cell_type	0.45
MAPK	associated_with	gene	0.45
STRIATUM	associated_with	brain_region	0.45
ERK	associated_with	gene	0.45
JNK	associated_with	gene	0.45
PYRUVATE	associated_with	phenotype	0.45

Incoming (195)

Source	Relation	Type	Str
Ginsenoside Rg3	inhibits	compound	0.85
Cantharidin	inhibits	compound	0.85
bone marrow microenvironment	activates	cell_type	0.82
THBS2	activates	gene	0.80
INSULIN_RESISTANCE	impairs	phenotype	0.80
SYK	causes	gene	0.70
LIPOGENESIS	regulates	phenotype	0.65
SARCOPENIA	targets	disease	0.65
ROS	phosphorylates	phenotype	0.65
ROS	activates	phenotype	0.65
ROS	regulates	phenotype	0.65
SLC7A11	inhibits	gene	0.65
CYTOKINES	inhibits	phenotype	0.65
FIBROSIS	inhibits	disease	0.65
TUMOR GROWTH	inhibits	phenotype	0.65
FERROPTOSIS	targets	phenotype	0.65
PARKINSON'S DISEASE	inhibits	disease	0.65
APOPTOSIS	inhibits	phenotype	0.65
PYRUVATE	inhibits	phenotype	0.65
PYRUVATE	regulates	phenotype	0.65
FIBROBLASTS	inhibits	cell_type	0.65
LIPID METABOLISM	inhibits	phenotype	0.65
LIPID METABOLISM	associated_with	phenotype	0.50
CELL PROLIFERATION	associated_with	phenotype	0.45
IRON ACCUMULATION	associated_with	phenotype	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
SUBSTANTIA NIGRA	associated_with	brain_region	0.45
DRUG RESISTANCE	associated_with	phenotype	0.45
INSULIN RESISTANCE	associated_with	phenotype	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PI3K/AKT/MTOR

Understanding Entity Pages

Wiki Pages (20)

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