disease

HEPATOCELLULAR CARCINOMA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HEPATOCELLULAR CARCINOMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

926Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	TGF-BETA, EXOSOMES, SLC7A11, NF-KB, MTOR, RAB7A, LRP1
KG Connections	201 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"] -->|"associated"| METASTASIS["METASTASIS"]
    style METASTASIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"] -->|"activates"| NF_KB["NF-KB"]
    style NF_KB fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"] -->|"activates"| AKT["AKT"]
    style AKT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"] -->|"expressed in"| T_CELLS["T CELLS"]
    style T_CELLS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"] -->|"regulates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    style OXIDATIVE_STRESS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"] -->|"regulates"| INFLAMMATION["INFLAMMATION"]
    style INFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"] -->|"regulates"| TGF_BETA["TGF-BETA"]
    style TGF_BETA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CELL_PROLIFERATION["CELL PROLIFERATION"] -->|"activates"| HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"]
    style CELL_PROLIFERATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    AUTOPHAGY["AUTOPHAGY"] -.->|"inhibits"| HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"]
    style AUTOPHAGY fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    METASTASIS_1["METASTASIS"] -->|"activates"| HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"]
    style METASTASIS_1 fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    TGF_BETA_2["TGF-BETA"] -->|"associated"| HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"]
    style TGF_BETA_2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    NF_KB_3["NF-KB"] -.->|"inhibits"| HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"]
    style NF_KB_3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style HEPATOCELLULAR_CARCINOMA fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (307)

Target	Relation	Type	Str
LIPOGENESIS	interacts_with	phenotype	0.65
LIPOGENESIS	activates	phenotype	0.65
NASH	interacts_with	disease	0.65
LIPID METABOLISM	targets	phenotype	0.65
METASTASIS	associated_with	process	0.58
ENDOTHELIAL CELLS	associated_with	concept	0.50
Tgf-Β Signaling	inhibits	pathway	0.50
FOXK2	associated_with	concept	0.50
Invasion	associated_with	pathway	0.50
Tumor Microenvironment	interacts_with	process	0.50
Immunotherapy	activates	process	0.50
Drug Resistance	interacts_with	pathway	0.50
Fatty Liver	associated_with	disease	0.50
Invasion	activates	pathway	0.50
CELL PROLIFERATION	activates	concept	0.50
STEM CELLS	interacts_with	concept	0.50
FIBROBLASTS	interacts_with	concept	0.50
CX3CR1	associated_with	gene	0.50
RAPAMYCIN	associated_with	drug	0.45
EXOSOME	associated_with	organelle	0.45
TH	associated_with	gene	0.45
PI3K	associated_with	gene	0.45
B7	associated_with	gene	0.45
LENVATINIB	associated_with	drug	0.45
RIBOSOME	associated_with	organelle	0.45
NF-KB	activates	gene	0.44
AKT	activates	gene	0.44
T CELLS	expressed_in	cell_type	0.35
T CELLS	activates	cell_type	0.35
OXIDATIVE STRESS	regulates	process	0.35
INFLAMMATION	regulates	process	0.35
TGF-BETA	regulates	gene	0.35
IMMUNE RESPONSE	therapeutic_target	process	0.35
PI3K/AKT SIGNALING	activates	process	0.35
OXIDATIVE PHOSPHORYLATION	therapeutic_target	process	0.35
PI3K	regulates	gene	0.35
PHAGOCYTOSIS	interacts_with	process	0.35
MACROPHAGES	interacts_with	cell_type	0.35
MACROPHAGES	associated_with	cell_type	0.35
MACROPHAGES	activates	cell_type	0.35
IL-6	activates	gene	0.35
HYPERTENSION	interacts_with	disease	0.35
LIPID METABOLISM	associated_with	process	0.35
MICRORNA REGULATION	expressed_in	process	0.35
HEPATOCYTES	associated_with	cell_type	0.35
OXIDATIVE STRESS	expressed_in	process	0.35
INFLAMMATION	expressed_in	process	0.35
TGF-BETA	expressed_in	gene	0.35
PGC-1ALPHA	activates	gene	0.35
PGC-1ALPHA	associated_with	gene	0.35

Incoming (619)

Source	Relation	Type	Str
SLC7A11	causes	gene	0.65
RIBOSOME	causes	organelle	0.65
CIRRHOSIS	increases_risk	disease	0.65
CELL PROLIFERATION	activates	process	0.50
AUTOPHAGY	inhibits	process	0.50
CARCINOMA	associated_with	disease	0.50
CARCINOMA	expressed_in	disease	0.50
Dna Methylation	expressed_in	pathway	0.50
RAB7A	causes	protein	0.50
TUMOR	causes	disease	0.50
CARCINOMA	causes	disease	0.50
ENDOTHELIAL	associated_with	concept	0.50
CARCINOMA	activates	disease	0.50
cancer	inhibits	disease	0.50
CARCINOMA	inhibits	disease	0.50
Tgf-Β	inhibits	pathway	0.50
COLORECTAL CANCER	inhibits	disease	0.50
SLC7A11	associated_with	gene	0.50
PPARGC1A	activates	gene	0.50
BAMBI	activates	concept	0.50
LRP1	activates	gene	0.50
UFL1	activates	protein	0.50
NF-κB	activates	concept	0.50
LRP1	associated_with	gene	0.50
Cirrhosis	associated_with	disease	0.50
cancer	interacts_with	disease	0.50
TUMOR	interacts_with	disease	0.50
CARCINOMA	interacts_with	disease	0.50
cancer	causes	disease	0.50
cancer	associated_with	disease	0.50
ferroptosis	activates	phenotype	0.50
Pi3K	activates	pathway	0.50
mitophagy	activates	pathway	0.50
Pi3K/Akt	activates	pathway	0.50
tmx2	activates	gene	0.50
Autophagy	activates	process	0.50
CARCINOMA	regulates	disease	0.50
FIBROSIS	associated_with	disease	0.50
GSK-3Β	inhibits	protein	0.50
Hepatitis	associated_with	disease	0.50
disease	associated_with	disease	0.50
Infection	associated_with	disease	0.50
MERTK	activates	gene	0.50
IL-10	activates	protein	0.50
PHAGOCYTOSIS	interacts_with	gene	0.50
Macrophage	interacts_with	cell_type	0.50
MACROPHAGES	interacts_with	concept	0.50
Macrophage	associated_with	cell_type	0.50
PRKAA1	expressed_in	gene	0.50
TUMOR	expressed_in	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HEPATOCELLULAR CARCINOMA

Understanding Entity Pages

Wiki Pages (20)

CLCN10 — Chloride Voltage-Gated Channel 10

MACF1 — Microtubule-actin crosslinking factor 1

GPT - Alanine Transaminase (ALT)

PDCD10 Gene (Programmed Cell Death 10)

TRIM32 Gene

TRIM3

can-fite-biopharma

HERC2 Gene

Ribosomal Protein S15a (RPS15A)

Gaucher Disease

WNT3 Gene

Biomarkers in Parkinsonian Syndromes (NCT06501469)

RPS5 — Ribosomal Protein S5

GOT1 Gene

DKK1 — Dickkopf WNT Signaling Pathway Inhibitor 1

Wilson's Disease Treatment

tmx2

MCC Gene