biological_process

METASTASIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about METASTASIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

827Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Biological Process Info

Name	METASTASIS
Key Genes/Proteins	PGC1A, AKT, MMP9, HDAC3, PI3K
Related Diseases	CANCER, EMT
Related Pathways	PI3K/AKT PATHWAY

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    METASTASIS["METASTASIS"] -->|"activates"| CANCER["CANCER"]
    style CANCER fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    METASTASIS["METASTASIS"] -->|"activates"| HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"]
    style HEPATOCELLULAR_CARCINOMA fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    METASTASIS["METASTASIS"] -->|"activates"| STAT3["STAT3"]
    style STAT3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    METASTASIS["METASTASIS"] -->|"regulates"| BREAST_CANCER["BREAST CANCER"]
    style BREAST_CANCER fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    METASTASIS["METASTASIS"] -->|"activates"| MTOR["MTOR"]
    style MTOR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    METASTASIS["METASTASIS"] -->|"activates"| AKT["AKT"]
    style AKT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    METASTASIS["METASTASIS"] -->|"activates"| CARCINOMA["CARCINOMA"]
    style CARCINOMA fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    EMT["EMT"] -->|"activates"| METASTASIS["METASTASIS"]
    style EMT fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    PGC1A["PGC1A"] -->|"activates"| METASTASIS["METASTASIS"]
    style PGC1A fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    TRF33["TRF33"] -.->|"inhibits"| METASTASIS["METASTASIS"]
    style TRF33 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    HEPATOCELLULAR_CARCINOMA_1["HEPATOCELLULAR CARCINOMA"] -->|"associated"| METASTASIS["METASTASIS"]
    style HEPATOCELLULAR_CARCINOMA_1 fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    EXOSOMES["EXOSOMES"] -->|"causes"| METASTASIS["METASTASIS"]
    style EXOSOMES fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style METASTASIS fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (84)

Target	Relation	Type	Str
CANCER	activates	disease	0.86
CANCER	associated_with	disease	0.72
CANCER	inhibits	disease	0.72
AKT	mediated_by	gene	0.65
EXOSOME	activates	organelle	0.65
MMP9	regulates	gene	0.65
HDAC3	regulates	gene	0.65
PI3K/AKT PATHWAY	regulates	pathway	0.65
PI3K/AKT PATHWAY	interacts_with	pathway	0.65
PI3K/AKT PATHWAY	activates	pathway	0.65
PI3K	interacts_with	gene	0.65
CANCER	regulates	disease	0.58
DRUG RESISTANCE	implicated_in	phenotype	0.55
GLIOMA	expressed_in	disease	0.55
ASPIRIN	associated_with	drug	0.45
EXOSOME	associated_with	organelle	0.45
LUTEOLIN	associated_with	drug	0.45
HEPATOCELLULAR CARCINOMA	activates	disease	0.44
HEPATOCELLULAR CARCINOMA	inhibits	disease	0.44
CANCER	causes	disease	0.44
STAT3	activates	gene	0.44
BREAST CANCER	regulates	disease	0.44
MTOR	activates	gene	0.44
AKT	activates	gene	0.44
NECROPTOSIS	co_discussed	process	0.40
OBESITY	co_discussed	disease	0.40
NEUROGENESIS	co_discussed	process	0.40
MTOR	co_discussed	gene	0.40
PI3K	co_discussed	gene	0.40
VEGF	co_discussed	gene	0.40
UBIQUITIN	co_discussed	protein	0.40
OXIDATIVE STRESS	co_discussed	process	0.40
MTOR SIGNALING	inhibits	process	0.35
NECROPTOSIS	regulates	process	0.35
NEUROGENESIS	activates	process	0.35
MTOR SIGNALING	activates	process	0.35
OBESITY	activates	disease	0.35
PI3K/AKT SIGNALING	regulates	process	0.35
VEGF	implicated_in	gene	0.35
PI3K/AKT SIGNALING	inhibits	process	0.35
NAFLD	metabolizes	disease	0.35
NAFLD	activates	disease	0.35
NAFLD	expressed_in	disease	0.35
MICRORNA REGULATION	activates	process	0.35
ORGANOIDS	expressed_in	cell_type	0.35
MICRORNA REGULATION	regulates	process	0.35
SLC7A11	implicated_in	gene	0.35
SLC7A11	inhibits	gene	0.35
CARCINOMA	activates	disease	0.30
FERROPTOSIS	inhibits	process	0.30

Incoming (743)

Source	Relation	Type	Str
CELL PROLIFERATION	activates	process	0.80
EMT	activates	phenotype	0.72
PGC1A	activates	protein	0.72
OXIDATIVE STRESS	promotes	process	0.70
CANCER	targets	disease	0.65
DRP1	causes	gene	0.65
ASPIRIN	protects_against	drug	0.65
P300	inhibits	gene	0.65
LUTEOLIN	inhibits	drug	0.65
LIPOGENESIS	inhibits	phenotype	0.65
TBK1	inhibits	gene	0.65
GLYCOLYSIS	inhibits	phenotype	0.65
TRF33	inhibits	gene	0.64
HEPATOCELLULAR CARCINOMA	associated_with	disease	0.58
OXIDATIVE STRESS	expressed_in	phenotype	0.55
ANGIOGENESIS	implicated_in	process	0.50
PI3K/AKT PATHWAY	associated_with	pathway	0.50
MTOR SIGNALING	associated_with	pathway	0.45
ASPIRIN	associated_with	drug	0.45
CANCER	co_discussed	disease	0.40
APOPTOSIS	co_discussed	process	0.40
INFLAMMATION	co_discussed	process	0.40
MACROPHAGE	co_discussed	cell_type	0.40
AUTOPHAGY	co_discussed	process	0.40
CELL PROLIFERATION	co_discussed	process	0.40
FERROPTOSIS	co_discussed	process	0.40
BREAST CANCER	co_discussed	disease	0.40
ANGIOGENESIS	co_discussed	process	0.40
LUNG CANCER	co_discussed	disease	0.40
LIPID METABOLISM	co_discussed	process	0.40
AKT	co_discussed	gene	0.40
IL6	co_discussed	gene	0.40
EPIGENETIC REGULATION	co_discussed	process	0.40
LRP1	co_discussed	gene	0.40
DRP1	co_discussed	gene	0.40
MELANOMA	co_discussed	disease	0.40
CELL MIGRATION	co_discussed	process	0.40
HDAC3	co_discussed	gene	0.40
LEUKEMIA	co_discussed	disease	0.40
MACROPHAGES	activates	cell_type	0.35
MACROPHAGES	expressed_in	cell_type	0.35
CASP3	activates	gene	0.35
EPIGENETIC REGULATION	inhibits	process	0.35
CELL PROLIFERATION	inhibits	process	0.35
CELL PROLIFERATION	implicated_in	process	0.35
CELL PROLIFERATION	associated_with	process	0.35
DRP1	inhibits	gene	0.35
DRP1	expressed_in	gene	0.35
CELL PROLIFERATION	regulates	process	0.35
ANGIOGENESIS	activates	process	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

METASTASIS

Understanding Entity Pages

Wiki Pages (20)

HNRNPA2B1 Protein

amyloid-beta-metalloproteinases

Epigenetic Dysregulation in Neurodegeneration

MACF1 — Microtubule-actin crosslinking factor 1

RNA Metabolism Dysregulation in Alzheimer's Disease

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

Extracellular Vesicles in Neurodegeneration

WNT4 Gene

Epigenetic Changes in PSP

FBXO3 Protein

Flotillin-1 Protein

Merkel Disc (Merkel Cells)

Huntingtin (HTT)

Chromatin Remodeling in Neurodegeneration

EPHA3 Gene

efnb1

CTS Gene - Cathepsin S

UNC5B — Netrin-1 Receptor