gene

SCD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

261Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

SCD1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, regulates. Associated with Aging, Als, Atherosclerosis. Connected to 131 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	SCD1
Chromosome	10q24.31
Protein Type	Enzyme
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	multiple cancers:
Molecular Weight	60 kDa
Amino Acids	360 aa
Pathways	Akt, Autophagy, Ferroptosis, Lipid Metabolism, Mtor
Ensembl ID	ENSG00000197294
GeneCards	SCD1
Human Protein Atlas	SCD1
Enzyme type	Membrane-bound desaturase (EC 1.14.19.3)
Location	Endoplasmic reticulum membrane
Substrate	Stearoyl-CoA (18:0), palmitoyl-CoA (16:0)
Product	Oleoyl-CoA (18:1), palmitoleoyl-CoA (16:1)
Associated Diseases	ALS, Cancer, Ferroptosis, Fibrosis, Neurodegeneration
Known Drugs/Compounds	Salidroside
Interactions	HMGCR, TNF, MLKL, ACSL4, GSDMD, FASN
KG Connections	261 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SCD1["SCD1"]
    SCD1 -->|"inhibits"| FERROPTOSIS["FERROPTOSIS"]
    SCD1 -->|"inhibits"| Inflammation["Inflammation"]
    SCD1 -->|"inhibits"| Hepatitis["Hepatitis"]
    SCD1 -->|"inhibits"| Fibrosis["Fibrosis"]
    SCD1 -->|"activates"| Cancer["Cancer"]
    SCD1 -->|"activates"| Tumor["Tumor"]
    SCD1 -->|"activates"| Aging["Aging"]
    SCD1 -->|"activates"| Ms["Ms"]
    SCD1 -->|"target for"| Als["Als"]
    SREBP1["SREBP1"] -->|"regulates"| SCD1
    FASN["FASN"] -->|"inhibits"| SCD1
    BAX["BAX"] -->|"inhibits"| SCD1
    ALOX15["ALOX15"] -->|"inhibits"| SCD1
    GSDMD["GSDMD"] -->|"inhibits"| SCD1
    MTOR["MTOR"] -->|"inhibits"| SCD1
    PTEN["PTEN"] -->|"activates"| SCD1
    ACSL4["ACSL4"] -->|"inhibits"| SCD1
    TNF["TNF"] -->|"inhibits"| SCD1

Outgoing (155)

Target	Relation	Type	Str
Ferroptosis Resistance	mediates	phenotype	0.90
Lipogenesis	mediates	process	0.90
fatty acid synthesis	involved_in	process	0.90
Ferroptosis	mediates	process	0.90
Monounsaturated Fatty Acid Phospholipids	upregulates	compound	0.85
Lipid Synthesis	involved_in	process	0.80
Tumor	regulates	disease	0.75
FERROPTOSIS	inhibits	phenotype	0.72
ferroptosis	participates_in	pathway	0.70
Lipid Metabolism	regulates	pathway	0.70
Lipid Metabolism	inhibits	pathway	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
Inflammation	inhibits	disease	0.65
Hepatitis	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Cardiac	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Neurodegeneration	causes	disease	0.65
Fatty Liver	therapeutic_target	disease	0.65
Breast Cancer	regulates	disease	0.65
Cancer	regulates	disease	0.65
Obesity	inhibits	disease	0.65
Insulin Resistance	inhibits	disease	0.65
Fatty Liver	inhibits	disease	0.65
Ms	regulates	disease	0.65
Ferroptosis	associated_with	disease	0.65
Fibrosis	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
HMGCR	inhibits	gene	0.60
TNF	inhibits	gene	0.60
MLKL	inhibits	gene	0.60
ACSL4	inhibits	gene	0.60
GSDMD	inhibits	gene	0.60
FASN	inhibits	gene	0.60
ALOX15	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
AKT	activates	gene	0.60
PTEN	activates	gene	0.60
BAX	inhibits	gene	0.60
PI3K	activates	gene	0.60
UBIQUITIN	regulates	gene	0.60
GCH1	activates	gene	0.60
ATF4	activates	gene	0.60

Incoming (106)

Source	Relation	Type	Str
SREBP1	upregulates	protein	0.95
EFTUD2	promotes	gene	0.90
EFTUD2	upregulates	gene	0.88
Mi-891	downregulates	drug	0.85
Salidroside	modulates	compound	0.85
SREBP1	regulates	gene	0.72
FASN	inhibits	gene	0.60
BAX	inhibits	gene	0.60
ALOX15	inhibits	gene	0.60
GSDMD	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
PTEN	activates	gene	0.60
ACSL4	inhibits	gene	0.60
TNF	inhibits	gene	0.60
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
PTEN	regulates	gene	0.60
P38	activates	gene	0.60
FAS	expressed_in	gene	0.60
CD36	expressed_in	gene	0.60
SPR	therapeutic_target	gene	0.60
CXCL1	inhibits	gene	0.60
EGR1	inhibits	gene	0.60
SOD1	contributes_to	gene	0.60
NR1D1	inhibits	gene	0.60
MLKL	inhibits	gene	0.60
HMGCR	inhibits	gene	0.60
GPX4	activates	gene	0.60
NCOA4	regulates	gene	0.60
PI3K	regulates	gene	0.60
CD36	inhibits	gene	0.60
FASN	expressed_in	entity	0.60
HMGCR	expressed_in	entity	0.60
AKT	associated_with	entity	0.60
MTOR	associated_with	entity	0.60
PI3K	associated_with	entity	0.60
MTOR	activates	entity	0.60
AKT	regulates	gene	0.60
MTOR	regulates	gene	0.60
GCH1	activates	gene	0.60
ATF4	activates	gene	0.60
FASN	activates	gene	0.60
PPAR	inhibits	gene	0.60
HMGCR	activates	gene	0.60
CD36	associated_with	gene	0.60
NCOA4	activates	gene	0.60
DHODH	activates	gene	0.60
FSP1	activates	gene	0.60
FTH1	activates	gene	0.60
SREBP1	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SCD1

Understanding Entity Pages

Summary

Wiki Pages (11)

SCD1 Gene

SPG35 Gene

Lipid Dysregulation in Neurodegeneration

SREBP1 Protein

FASN Gene

APOE4 (Apolipoprotein E4)

SREBP1 Protein (Sterol Regulatory Element-Binding Protein 1)

SREBF1 Gene

SCD1 Protein