Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Lead: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| reactive oxygen species production | promotes | process | 0.95 |
| neurodegeneration | causes | process | 0.95 |
| oxidative stress | promotes | process | 0.90 |
| NFE2L2 | promotes | gene | 0.90 |
| APP | upregulates | protein | 0.88 |
| BACE1 | upregulates | protein | 0.87 |
| blood-brain barrier | associated_with | cell_type | 0.85 |
| behaviour | associated_with | phenotype | 0.80 |
| necroptosis | activates | process | 0.70 |
| hippocampal neurons | causes | cell_type | 0.70 |
| TNF-R1 | activates | protein | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Age-Dependent TREM2 Signaling Disrupts Astrocyte-Microglia C | 0.649 | neurodegeneration | Gene expression changes in aging mouse b |
| SASP-Secreted MMP-9 from Senescent Microglia Disrupts TDP-43 | 0.511 | als | What are the mechanisms by which microgl |
| Patients with OSA or high nocturnal arousal burden may requi | 0.370 | neurodegeneration | - |
| SASP-Secreted MMP-9 from Senescent Microglia Disrupts Nuclea | 0.361 | als | What are the mechanisms by which microgl |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Loss of Nuclear TDP-43 Impairs Lipid Metabolism in Microglia-Like Cells. [PMID:41000837] | Unknown | bioRxiv | 2025 | 0 |
| Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopat [PMID:34412701] | Unknown | Acta Neuropathol Commun | 2021 | 0 |
| Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP- [PMID:30458231] | Unknown | Neurobiology of disease | 2019 | 0 |
| TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synaps [PMID:28669544] | Unknown | Neuron | 2017 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Lead in their description or question text
No additional research found