Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MAPK SIGNALING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MAPK SIGNALING PATHWAY |
Knowledge base pages for this entity
graph TD
MAPK_SIGNALING_PATHWAY["MAPK SIGNALING PATHWAY"]
MAPK_SIGNALING_PATHWAY -->|"activates"| Pyroptosis["Pyroptosis"]
MAPK_SIGNALING_PATHWAY -->|"activates"| Inflammation["Inflammation"]
MAPK_SIGNALING_PATHWAY -->|"regulates"| Neuroinflammatory_Responses["Neuroinflammatory Responses"]
MAPK_SIGNALING_PATHWAY -->|"mediates"| Neuroprotection["Neuroprotection"]
MAPK_SIGNALING_PATHWAY -->|"involved_in"| EV_A71_Infection["EV-A71 Infection"]
RAS["RAS"] -->|"upstream_of"| MAPK_SIGNALING_PATHWAY
Berberine["Berberine"] -->|"inhibits"| MAPK_SIGNALING_PATHWAY
DUSP1["DUSP1"] -->|"inhibits"| MAPK_SIGNALING_PATHWAY
Naringenin["Naringenin"] -->|"inhibits"| MAPK_SIGNALING_PATHWAY
Macluraparishin_C["Macluraparishin C"] -->|"activates"| MAPK_SIGNALING_PATHWAY
berberine["berberine"] -->|"inhibits"| MAPK_SIGNALING_PATHWAY
Yiqi_Tongluo_Granule["Yiqi Tongluo Granule"] -->|"regulates"| MAPK_SIGNALING_PATHWAY
TP53["TP53"] -->|"interacts"| MAPK_SIGNALING_PATHWAY| Target | Relation | Type | Str |
|---|---|---|---|
| Tnf-Α/Nf-Κb/Mapk Signaling Pathway | involved_in | pathway | 0.90 |
| Neuroinflammatory Responses | regulates | process | 0.85 |
| Colitis-Associated Colorectal Cancer | associated_with | disease | 0.85 |
| Pyroptosis | activates | process | 0.85 |
| Inflammation | activates | process | 0.85 |
| Neuroprotection | mediates | process | 0.85 |
| Neuroinflammation | promotes | process | 0.85 |
| Mitochondrial Dysfunction | regulates | process | 0.85 |
| EV-A71 Infection | involved_in | process | 0.80 |
| neuroinflammation | regulates | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Berberine | inhibits | compound | 0.95 |
| RAS | upstream_of | protein | 0.95 |
| Berberine | inhibits | compound | 0.92 |
| DUSP1 | inhibits | protein | 0.90 |
| Macluraparishin C | activates | compound | 0.90 |
| berberine | inhibits | drug | 0.90 |
| Indirubin | inhibits | compound | 0.90 |
| Yiqi Tongluo Granule | regulates | drug | 0.80 |
| TP53 | interacts_with | gene | 0.72 |
| quercetin | regulates | drug | 0.70 |
| Luteolin | modulates | compound | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||