Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MDA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Ferroptosis | indicates | pathway | 0.70 |
| late-stage disease | biomarker_for | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AE | downregulates | compound | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Cortico-Striatal Synchrony Restoration via NMDA Modulation | 0.950 | neuroscience | Circuit-level neural dynamics in neurode |
| Thalamocortical Synchrony Restoration via NMDA Modulation | 0.774 | neuroscience | Circuit-level neural dynamics in neurode |
| Fyn-anchored dendritic tau/NMDAR signaling persists after tr | 0.670 | neurodegeneration | Does tau dendritic missorting persist in |
| Subtle NMDAR Inhibition Attenuates Excitotoxicity-Driven Tau | 0.620 | neurodegeneration | Investigate prion-like spreading of tau |
| Synaptic NMDAR Subtype Targeting Prevents Excitotoxicity | 0.520 | neurodegeneration | Test Preregistration Analysis |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-18 | 4 hypotheses Top: 0.538
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Inspired by molecular dynamic simulation, exploring chemical constituents of alc [PMID:40166865] | Shinge J, Muthal A, Walhekar V, Bagul C, | Journal of biomolecular struct | 2026 | 0 |
| Cognitive loss after brain trauma results from sex-specific activation of synapt [PMID:40796363] | Arizanovska D, Bush GF, Dallera CA, Folo | Brain | 2026 | 0 |
| Inhibition of GluN2B-containing N-methyl-D-aspartate receptors by radiprodil. [PMID:40994429] | Banke TG, Regan MC, Perszyk RE, Zhang L, | Brain | 2026 | 0 |
| GluN2B-specific NMDAR positive allosteric modulation reverses cognitive and beha [PMID:41512078] | Ge Y, Tian T, Li B, Axerio-Cillies P, Ch | Sci Adv | 2026 | 0 |
| Zipper-interacting Protein Kinase Modulates Gene Expression Linked to Synaptic a [PMID:41526727] | Mei Y, Zheng L, He M, Wang L, Zhou Y et | Mol Neurobiol | 2026 | 0 |
| Multi-biofluid metabolomics coupled with gene network reveals stage-specific alt [PMID:41534821] | Cadaxo AS, Cotrin JC, Valente AP, Lopes | Brain Res | 2026 | 0 |
| Aberrant mRNA splicing and impaired hippocampal neurogenesis in Grin2b mutant mi [PMID:41675057] | Farsi Z, Nicolella A, Simmons SK, Shin W | iScience | 2026 | 0 |
| From synapse to system: mechanistic pathways of neural signaling dysfunction in [PMID:41799440] | Gupta R, Jha NK, Kumar N, Nagraik R, Rav | Front Cell Dev Biol | 2026 | 0 |
| Multisession epidural direct current stimulation of the auditory cortex mitigate [PMID:41747412] | Fernández Del Campo IS, Cebrián-León A, | Hearing research | 2026 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning MDA in their description or question text
No additional research found