gene 2,946 words KG: GRIN1 2026-03-24
kind:genesection:genesstate:published
Contents

GRIN1 — NMDA Receptor Subunit 1

🧬 Gene Info
Gene SymbolGRIN1
Full NameGRIN1 — NMDA Receptor Subunit 1
Chromosome9q34.1
Protein TypeProtein
Functionof 938 amino acids
Molecular Weight105 kDa
Amino Acids938 aa
Exons21
PathwaysSRC-mediated Phosphorylation
UniProt IDSearch UniProt
NCBI Gene IDSearch NCBI
GeneCardsGRIN1
Human Protein AtlasGRIN1
Associated DiseasesHuntington's disease, Memory Impairment
Known Drugs/CompoundsD-glutamate
InteractionsHCRTR1, DRD2, HRH3, HCRTR2, ADRA1B, DRD1
KG Connections48 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.55
Orexin-Microglia Modulation Therapy
Score: 0.49
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.48

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived

See Also (15)

Packard Center for ALS Research
institution · KG edge: activates
HRH3 Gene
gene · KG edge: activates
HCRTR1
gene · KG edge: activates
GRIA1 Gene
gene · KG edge: activates
GRB2 — Growth Factor Receptor Bound Protein 2
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

GRIN1 activates HCRTR1
GRIN1 therapeutic_target ADAM10
GRIN1 associated_with Memory Impairment
GRIN1 causes HTT
GRIN1 causes MBNL1
GRIN1 interacts_with D-glutamate
GRIN1 mediates calcium signaling
GRIN1 associated_with HCN1
GRIN1 associated_with KMT2D
GRIN1 associated_with MECP2