entity 1,004 words KG: NMDA 2026-03-24
kind:entitysection:entitiesstate:published
Contents

NMDA Receptor

🔬 Protein Info
Gene SymbolNMDA
AliasesGRIN2B, GRIN1
Molecular Weight166 kDa
Pathwaysglutamate signaling, unfolded protein response, oxidative stress response, mitochondrial function, sphingolipid metabolism
GeneCardsNMDA
Human Protein AtlasNMDA
Associated DiseasesALS, Alzheimer, Alzheimer'S Disease, Huntington, disease, epilepsy
Known Drugs/Compoundsmemantine
InteractionsSLC17A7, PSD-95, TET2, ROS, VPS35, P2Y12
KG Connections134 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95
Score: 0.69
Closed-loop focused ultrasound targeting CA1 PV interneurons
Score: 0.61
Direct Toxicity Hypothesis: β-Amyloid Directly Impairs Choli
Score: 0.60
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59
Context-Dependent Cx43 Modulation Based on Disease Stage
Score: 0.58

Related Analyses (22)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (4)

Ketamine in pediatric TRD patients
clinical · proposed · Score: 0.70
Ketamine in obstetric TRD patients
clinical · proposed · Score: 0.70
Ketamine efficacy in geriatric TRD patients
clinical · proposed · Score: 0.70
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40

See Also (10)

Memantine - NMDA Antagonist for Alzheimer's Disease
therapeutic · KG edge: activates
Alzheimer Indonesia
institution · KG edge: co_discussed
GRIN2A Gene
gene · KG edge: activates
DBN1 — Drebrin
gene · KG edge: associated_with
Genes
index · KG edge: co_discussed

Knowledge Graph (12 edges)

NMDA activates P2Y12
NMDA activates AMPA RECEPTOR
NMDA activates NMDA RECEPTOR
NMDA activates GLUTAMATE
NMDA protects_against NMDA-RECEPTOR
NMDA protects_against NEUROTOXICITY
NMDA associated_with NMDA-RECEPTOR
NMDA associated_with ALZHEIMER
NMDA associated_with Alzheimer'S Disease
NMDA associated_with disease