entity

AE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

11Hypotheses

0Analyses

12Outgoing

0Incoming

0Experiments

0Debates

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Wiki Pages (2)

Knowledge base pages for this entity

YWHAE Protein

protein · 1041 words

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YWHAE Gene

gene · 514 words

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Outgoing (12)

Target	Relation	Type	Str
mTOR	activates	protein	0.80
NF-κB	inhibits	protein	0.80
TNF-α	downregulates	protein	0.80
PI3K	activates	protein	0.80
AKT	activates	protein	0.80
MDA	downregulates	compound	0.80
LDH	downregulates	protein	0.80
Caspase 3	downregulates	protein	0.80
SOD	upregulates	protein	0.80
Bcl-2	upregulates	protein	0.80
Bax	downregulates	protein	0.80
Ischemic stroke	treats	disease	0.80

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (11)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ω-3 Docosahexaenoic Acid (DHA) Epoxide Generation via CYP2J2	0.802	lipidomics	Lipid metabolism dysregulation in Alzhei
OPA1-Mediated Cristae Architecture Vulnerability	0.490	neurodegeneration	What determines the specificity of TDP-4
Astrocytic APOE4 Disruption of GABAergic Support Increasing	0.450	neurodegeneration	How does APOE4 mechanistically increase
GABAergic Hub Stabilization Through α5-Subunit Inverse Agoni	0.430	connectomics	Human connectome alterations in Alzheime
ω-3 Docosahexaenoic Acid (DHA) Metabolism via 15-Lipoxygenas	0.380	lipidomics	Lipid metabolism dysregulation in Alzhei

Prevotellaceae-Mediated Enteric Nervous System Priming Theor	0.000	-	Does reduced Prevotellaceae abundance ca
Systemic Metabolic Reprogramming via Prevotellaceae Loss	0.000	-	Does reduced Prevotellaceae abundance ca
Prevotellaceae-Derived Butyrate Supplementation as Neuroprot	0.000	-	What are the mechanisms by which gut mic
Prevotellaceae as Dopamine Precursor Modulators	0.000	-	Does reduced Prevotellaceae abundance ca
Prevotellaceae Metabolite Depletion as Alpha-Synuclein Aggre	0.000	-	Does reduced Prevotellaceae abundance ca
Immune Tolerance Breakdown via Prevotellaceae Depletion	0.000	-	Does reduced Prevotellaceae abundance ca

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (4)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Memorable Food: Fighting Age-Related Neurodegeneration by Precision Nutrition. [PMID:34422879]	["Milo\u0161evi\u0107 M", "Arsi\u0107 A"	Frontiers in nutrition	2021
Dietary DHA and health: cognitive function ageing. [PMID:27866493]	Unknown	Nutr Res Rev	2016
Docosahexaenoic acid and synaptic protection in Alzheimer's disease mice. [PMID:20211757]	Unknown	Biochim Biophys Acta	2010
Survival signalling in Alzheimer's disease. [PMID:17073801]	Unknown	Biochem Soc Trans	2006

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity