protein

MGLUR2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MGLUR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

10Outgoing

0Incoming

0Experiments

0Debates

Summary

Metabotropic glutamate receptor 2 (mGluR2/GRM2) is a Group II GPCR that inhibits glutamate release, modulates synaptic transmission, and is implicated in neurodegenerative diseases including Alzheimer's and Parkinson's disease.

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🔬 Protein Info

Gene Symbol	MGLUR2
Aliases	mGluR2/GRM2
Chromosome	7q31.1
Protein Type	Receptor
Function	mGluR2 is a Group II metabotropic glutamate receptor coupled to Gi/o proteins.
Molecular Weight	96 kDa
Exons	10
Pathways	NF-κB
GeneCards	MGLUR2
Human Protein Atlas	MGLUR2
Associated Diseases	neurodegeneration
Interactions	AMYLOID, AMYLOID-BETA
KG Connections	10 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

mGluR2 Protein

protein · 716 words

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Pathway Diagram

graph TD
    MGLUR2("MGLUR2")
    Alzheimer{"Alzheimer"}
    MGLUR2 -->|"regulates"| Alzheimer
    ALZHEIMER["ALZHEIMER"]
    MGLUR2 -->|"regulates"| ALZHEIMER
    AND["AND"]
    MGLUR2 -->|"regulates"| AND
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    MGLUR2 -->|"regulates"| ALZHEIMER_S_DISEASE
    AMYLOID["AMYLOID"]
    MGLUR2 -->|"activates"| AMYLOID
    AMYLOID_BETA["AMYLOID-BETA"]
    MGLUR2 -->|"activates"| AMYLOID_BETA
    Amyloid(["Amyloid"])
    MGLUR2 -->|"activates"| Amyloid
    Alzheimer_S_Disease{"Alzheimer'S Disease"}
    MGLUR2 -->|"regulates"| Alzheimer_S_Disease
    disease{"disease"}
    MGLUR2 -->|"regulates"| disease
    ALZHEIMER_S["ALZHEIMER'S"]
    MGLUR2 -->|"regulates"| ALZHEIMER_S
    GLUTAMATE["GLUTAMATE"]
    MGLUR2 -->|"regulates"| GLUTAMATE
    neurodegeneration["neurodegeneration"]
    MGLUR2 -->|"implicated_in"| neurodegeneration

Outgoing (10)

Target	Relation	Type	Str
Alzheimer	regulates	disease	0.65
ALZHEIMER	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
AMYLOID	activates	gene	0.60
AMYLOID-BETA	activates	gene	0.60
Amyloid	activates	pathway	0.60
Alzheimer'S Disease	regulates	disease	0.50
disease	regulates	disease	0.50
ALZHEIMER'S	regulates	concept	0.50
GLUTAMATE	regulates	concept	0.50

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MGLUR2 in their description or question text

No additional research found